Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According…
Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to SizeRiccardo De Robertis1, Giovanni Marchegiani2, Matteo Catania3, Maria Chiara Ambrosetti3, Paola Capelli4, Roberto Salvia2 and Mirko D’Onofrio3 Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-8. 10.2214/AJR.18.20715AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload CitationABSTRACT :OBJECTIVE. The purpose of this study was to retrospectively…

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Medicine by Alexandros G. Sfakianakis

10:08

Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived…
Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile VentriculomegalyRupa Radhakrishnan1,2, Brandon Patrick Brown1,2, Stephen F. Kralik3, Danielle Bain2, Scott Persohn2, Paul R. Territo2, Andrew Jea4, Boaz Karmazyn1,2, Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-7. 10.2214/AJR.19.21261AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload…

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Medicine by Alexandros G. Sfakianakis

10:08

Percutaneous Image-Guided Cryoablation of Osteoblastoma Roberto Luigi Cazzato1, Pierre Auloge1, Danoob…
Percutaneous Image-Guided Cryoablation of OsteoblastomaRoberto Luigi Cazzato1, Pierre Auloge1, Danoob Dalili2,3, Pierre De Marini1, Antonio Di Marco4, Julien Garnon1 and Afshin Gangi1 Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-6. 10.2214/AJR.19.21390AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload CitationABSTRACT :OBJECTIVE. The aim of this observational study was to assess safety and clinical outcomes of percutaneous image-guided cryoablation…

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Medicine by Alexandros G. Sfakianakis

10:07

Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome…
Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic SyndromeHalim Awadie, Johad Khoury, Yaniv Zohar, Afif Yaccob, Ella Veitsman, and Tarek SaadiAbstractIdiopathic hypereosinophilic syndrome (HES) is a rare, heterogeneous disorder characterized by a strikingly high eosinophil count (>1,500 cells/µL), over a long period of time (>6 months), with end organ damage. We present a 60-year-old patient with idiopathic HES with isolated liver involvement, a…

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Medicine by Alexandros G. Sfakianakis

10:07

Vape Gods and Judaism—E-cigarettes and Jewish Law, Sharon GalperAbstract Objective: To review current…
Vape Gods and Judaism—E-cigarettes and Jewish Law,Sharon GalperAbstractObjective: To review current medical literature on the risks and potential benefits of e-cigarette use and its permissibility under Jewish law. Methods: A survey of current medical literature about the risks and potential benefits of e-cigarette use, and a review of existing rabbinic literature regarding both combustible and e-cigarette products. Results: E-cigarettes contain fewer harmful materials than do combustible cigarettes….

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Medicine by Alexandros G. Sfakianakis

10:07

A Comparison of Manual versus Electric Bicycle Injuries Presenting to a Pediatric Emergency Department…
A Comparison of Manual versus Electric Bicycle Injuries Presenting to a Pediatric Emergency DepartmentTali Capua, Miguel Glatstein, Karin Hermon, Oren Tavor, Dennis Scolnik, Veronika Kusaev, and Ayelet RimonAbstractBackground: The use of electric bicycles (E-bikes) has dramatically increased over the last decade. E-bikes offer an inexpensive, alternative form of transport, but also pose a new public health challenge in terms of safety and injury prevention. Objective: The aim of this study was to…

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Medicine by Alexandros G. Sfakianakis

10:06

Something Must Be Wrong with the Implementation of Cancer-pain Treatment Guidelines. A Lesson from…
Something Must Be Wrong with the Implementation of Cancer-pain Treatment Guidelines. A Lesson from Referrals to a Pain ClinicGil Samuelly-Leichtag, Tsiki Adler, and Elon EisenbergAbstractObjective: The World Health Organization’s (WHO) guidelines for cancer pain management were intentionally made simple in order to be widely implemented by all physicians treating cancer patients. Referrals to pain specialists are advised if pain does not improve within a short time. The present study examined whether…

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Medicine by Alexandros G. Sfakianakis

10:06

Morphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial…
Morphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial Dysplasia Using Verhoeff–Van Gieson StainJanardhanam Dineshshankar, Nalliappan Ganapathy, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Jeyaraman Swathiraman, Thangadurai Maheswaran, and Vadivel IlayarajaAbstractBackground: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in India. The aggressiveness of OSCC is analyzed not only based on the dysplastic features and…

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Medicine by Alexandros G. Sfakianakis

10:06

Rational Use of Medicine in Children—The Conflict of Interests Story. A Review Klaus Rose, David Neubauer,…
Rational Use of Medicine in Children—The Conflict of Interests Story. A ReviewKlaus Rose, David Neubauer, and Jane M. Grant-KelsAbstractBackground: United States (US) and European Union (EU) legislation attempts to counterbalance the presumed discrimination in pediatric drug treatment and development. Methods: We analyzed the history of drug development, US/EU pediatric laws, and pediatric studies required by US/EU regulatory authorities and reviewed relevant literature. Results: The US and EU definitions…

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Medicine by Alexandros G. Sfakianakis

10:06

Trends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015), Konstantinos…
Trends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015),Konstantinos Z. Vardakas, Katerina N. Apiranthiti, Spiridoula E. Almpani, Dominiki Heliou, Dimitra Stratigopoulou, Eleni Giourmetaki, Dimitra Lamprou, Georgia Binou, Elena Mpaltzoglou, Margarita Kyriakidou, and Matthew E. FalagasAbstractObjectives: To study mortality changes in Greece prior to and during the financial crisis. Study design: Analysis of data by the Hellenic Statistical Authority (1955–2013)….

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Medicine by Alexandros G. Sfakianakis

10:05

Rambam Maimonides Medical Journal
Original ResearchMorphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial Dysplasia Using Verhoeff–Van Gieson StainJanardhanam Dineshshankar, Nalliappan Ganapathy, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Jeyaraman Swathiraman, Thangadurai Maheswaran, and Vadivel IlayarajaTrends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015)Konstantinos Z. Vardakas, Katerina N. Apiranthiti, Spiridoula E. Almpani, Dominiki…

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Medicine by Alexandros G. Sfakianakis

10:04

Assessment of myocardial viability by myocardial contrast echocardiography: current perspectives Purpose…
Assessment of myocardial viability by myocardial contrast echocardiography: current perspectivesPurpose of review The current guidelines recommend the use of myocardial contrast echocardiography (MCE) to assess myocardial viability. There are two clinical scenarios where detection of myocardial viability has clinical significance: in ischemic cardiomyopathy and following acute myocardial infarction with significant left ventricular dysfunction. Myocardial contrast echocardiography (MCE), which utilizes…

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Medicine by Alexandros G. Sfakianakis

10:02

Surgical Oncology
EDITORIALSentinel node biopsy for cancer of the oral cavityJames X. Wu MD Martin Hanson MD Ashok R. ShahaPages: 99-100 First Published: 16 May 2019Full text PDF ReferencesRequest permissionsRESEARCH ARTICLESSentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinomaJohn T. Loree BA Saurin R. Popat MD Mark S. Burke MD Jennifer Frustino DDS, PhDJeewanjot S. Grewal BA Thom R. Loree MDPages: 101-108 First Published: 16 May 2019Abstract Full text PDF ReferencesRequest…

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Medicine by Alexandros G. Sfakianakis

10:01

Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma, John…
Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma,John T. Loree BA Saurin R. Popat MD Mark S. Burke MD Jennifer Frustino DDS, PhD Jeewanjot S. Grewal BA Thom R. Loree MDFirst published: 16 May 2019 https://doi.org/10.1002/jso.25494 Cited by: 1Read the full textePDFPDFTOOLS SHAREAbstractBackground and ObjectivesThe management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper…

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Medicine by Alexandros G. Sfakianakis

09:59

Sarcomas of the mandible, Ivana Petrovic DMD Zain U. Ahmed Ashley Hay MBChB, MRCS, DOHNS, FRCS …
Sarcomas of the mandible,Ivana Petrovic DMD Zain U. Ahmed Ashley Hay MBChB, MRCS, DOHNS, FRCS Evan B. Rosen DMD, MPH Chuanyong Lu MD Meera Hameed MD Jatin P. Shah MD, PhD, DSc, FRCS(Hon)First published: 16 April 2019 https://doi.org/10.1002/jso.25477Read the full textePDFPDFTOOLS SHAREAbstractIntroductionSarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing’s sarcomaMaterials and methodsA retrospective review of the clinical records,…

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Medicine by Alexandros G. Sfakianakis

09:58

Traditional sugar-sweetened beverages, sweetened teas, and blended milk-based beverages (e.g., milkshakes) were significantly higher in calories from 2012 to 2017 for newly introduced beverages (p-value for trend 0.004). For all newly introduced sweetened beverages, sugar increased significantly (2015, +7.9 g; 2016, +8.2 g; p0.004) whereas saturated fat declined (2016, −2.3 g; 2017, −1.6 g; p0.004). For beverages on menus in all years, saturated fat declined significantly (p0.001), whereas mean calories and sugar remained relatively constant. Significant declines were observed for sweetened coffees (−10 kcal, −0.5 g saturated fat, p0.001), teas (−2.6 g sugar, p=0.001), and blended milk-based beverages (−28 kcal, −4.2 g sugar, −0.8 g saturated fat, p0.001). From 2012 to 2017, the total number of beverage offerings increased by 155%, with 82% of this change driven by sweetened beverages.
Trends in Calories and Nutrients of Beverages in U.S. Chain Restaurants, 2012–2017Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Johannah M. Frelier, Alyssa J. Moran, Kelsey A. Vercammen, Marian P. Jarlenski, Sara N. BleichIntroductionAlthough beverages comprise one third of all menu items at large chain restaurants, no prior research has examined trends in their calorie and nutrient content.MethodsBeverages (n=13,879) on the menus of 63…

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Medicine by Alexandros G. Sfakianakis

09:58

Lung Cancer Screening Utilization: A Behavioral Risk Factor Surveillance System Analysis, Publication…
Lung Cancer Screening Utilization: A Behavioral Risk Factor Surveillance System Analysis,Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Whitney E. Zahnd, Jan M. EberthIntroductionLung cancer is the leading cause of cancer-related death in the U.S. The National Lung Screening Trial found that low-dose computed tomography reduced lung cancer mortality in high-risk individuals. As a result, the U.S. Preventive Services Task Force began recommending…

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Medicine by Alexandros G. Sfakianakis

09:56

Preventive Medicine
Binge Drinking and Prescription Opioid Misuse in the U.S., 2012–2014Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Marissa B. Esser, Gery P. Guy, Kun Zhang, Robert D. BrewerIntroductionPrescription opioids were responsible for approximately 17,000 deaths in the U.S. in 2016. One in five prescription opioid deaths also involve alcohol. Drinkers who misuse prescription opioids (i.e., use without a prescription or use only for the experience…

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Medicine by Alexandros G. Sfakianakis

09:56

Wolters Kluwer Health At A Glance, New Journals Website Launched with Inaugural Issue Journal of…
Wolters Kluwer Health At A Glance,New Journals Website Launched with Inaugural IssueJournal of Oral and Maxillofacial RadiologyySahel Medical JournalSaudi Journal of Sports MedicineJournal of Orthodontic ResearchMuller Journal of Medical Sciences and ResearchASL- Musculoskeletal DiseasesWest African Journal of Radiology79 Issues submitted to appropriate Indexing Agencies such as EBSCO, ProQuest, Swet, Thomson, IndMed, Portico, Infotrieve and Exlibris. 3 New Journals Accepted in NLM and PMC/PubMed:Nigerian…

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Medicine by Alexandros G. Sfakianakis

09:55

American Journal of Roentgenology
Gastrointestinal ImagingOriginal ResearchSolid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to SizeRiccardo De Robertis, et al. | American Journal of Roentgenology | Jul 16, 2019Ahead of PrintPediatric ImagingOriginal ResearchFrontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile VentriculomegalyRupa Radhakrishnan, et al. | American Journal of Roentgenology…

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Medicine by Alexandros G. Sfakianakis

09:53



Mycoses Early View Online Version of Record before inclusion in an issue Open AccessMucormycosis…
MycosesEarly ViewOnline Version of Record before inclusion in an issue Open AccessMucormycosis in South America: A review of 143 reported casesMarcio Nucci, Marc Engelhardt, Kamal HamedVersion of Record online: 11 July 2019 Open AccessFirst application of loop‐mediated isothermal amplification (LAMP) assays for rapid identification of mating type in the heterothallic fungus Aspergillus fumigatusKevin M. King, Nichola J. Hawkins, Sarah Atkins, Paul S. Dyer, Jonathan S. West, Bart A. FraaijeVersion…

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Medicine by Alexandros G. Sfakianakis

09:52

Pulmonary cryptococcosis characteristics in immunocompetent patients—A twenty‐year clinical retrospective…
Pulmonary cryptococcosis characteristics in immunocompetent patients—A twenty‐year clinical retrospective analysis in China,Xiaomeng Hou, Lei Kou, Xiaozhen Han, Rui Zhu, Lan Song, Tao LiuFirst Published: 09 July 2019

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Medicine by Alexandros G. Sfakianakis

09:51

Food Sources of Potassium, https://www.webmd.com/diet/foods-rich-in-potassium Many of the foods that…
Food Sources of Potassium,https://www.webmd.com/diet/foods-rich-in-potassiumMany of the foods that you already eat contain potassium. The foods listed below are high in potassium. If you need to boost the amount of potassium in your diet, make healthy food choices by picking items below to add to your menu.Many fresh fruits and vegetables are rich in potassium:Bananas, oranges, cantaloupe, honeydew, apricots, grapefruit (some dried fruits, such as prunes, raisins, and dates, are also high in potassium)Cooked…

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Medicine by Alexandros G. Sfakianakis

09:50

Hyperphosphataemia in 2019: have we made progress? Purpose of review This review describes recent developments…
Hyperphosphataemia in 2019: have we made progress?Purpose of review This review describes recent developments in the management of serum phosphate in dialysis patients, with a focus on the development of recent trials which randomize patients to different levels of control. Recent findings We review the uncertainties around clinical benefits of serum phosphate control and alternative approaches to current management, as well as a multinational attempt to conduct randomized controlled trials in this…

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Medicine by Alexandros G. Sfakianakis

09:50

Updates on medical management of hyperkalemia, Purpose of review Hyperkalemia is a potentially fatal…
Updates on medical management of hyperkalemia,Purpose of review Hyperkalemia is a potentially fatal electrolyte disorder, more commonly present when the potassium excretion capacity is imparied. Hyperkalemia can lead to adverse outcomes, especially due to severe cardiac arrhythmias. It can also impair the cardiovascular effects of renin–angiotensin–aldosterone system inhibitors (RAASis) and potassium rich diets, as hyperkalemia frequently leads to their discontinuation. Recent findings Potassium…

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Medicine by Alexandros G. Sfakianakis

09:48

Recent developments in the management of acute and chronic hyponatremia, Purpose of review The aim…
Recent developments in the management of acute and chronic hyponatremia,Purpose of review The aim of the study is to review recent studies on the management of acute and chronic hyponatremia. Recent findings In acute symptomatic hyponatremia, bolus infusion of hypertonic saline improves hyponatremia and neurological status more quickly than continuous infusion. In chronic hyponatremia, newly identified predictors of nonresponse to fluid restriction include a high urine osmolality (>500 mOsm/kg)…

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Medicine by Alexandros G. Sfakianakis

09:47

Hyponatremia in patients with cancer, Purpose of review Hyponatremia is seen commonly in patients…
Hyponatremia in patients with cancer,Purpose of review Hyponatremia is seen commonly in patients with cancer and is associated with increased mortality and morbidity. Understanding the proper diagnosis and therapy of cancer-associated hyponatremia is critical to ensure improved outcomes. Recent findings The most common cancers associated with hyponatremia are the various forms of lung cancer with incidences approaching 25–45%. The most common causes of hyponatremia in cancer patients are the syndrome…

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Medicine by Alexandros G. Sfakianakis

09:47

Nephrology and Hypertension
Cullin-Ring ubiquitin ligases in kidney health and diseasePurpose of review Members of the Cullin family act as scaffolds in E3 ubiquitin ligases and play a central role in mediating protein degradation. Interactions with many different substrate-binding adaptors permit Cullin-containing E3 ligases to participate in diverse cellular functions. In the kidney, one well established target of Cullin-mediated degradation is the transcription factor Nrf2, a key player in responses to oxidative stress….

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Medicine by Alexandros G. Sfakianakis

09:46

The right treatment for the right ventricle, Purpose of review Right ventricular (RV) function is an…
The right treatment for the right ventricle,Purpose of review Right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH). Although substantial progress has been made in understanding the development of RV failure in the last decennia, this has not yet resulted in the development of RV selective therapies. In this review, we will discuss the current status on the treatment of RV failure and potential novel therapeutic…

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Medicine by Alexandros G. Sfakianakis

09:45

Noninvasive volume-assured pressure support for chronic respiratory failure: a review Purpose of review…
Noninvasive volume-assured pressure support for chronic respiratory failure: a reviewPurpose of review Noninvasive ventilation (NIV) is an established treatment for chronic hypercapnic respiratory failure (CRF). Volume-assured pressure support (VAPS) is a mode of NIV that automatically adjusts inspiratory pressure in order to maintain a constant respiratory volume. We aim to discuss the role and application of VAPS in CRF. Recent findings Recently published meta-analyses and reviews fail to demonstrate…

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Medicine by Alexandros G. Sfakianakis

09:45

Unilateral phrenic nerve stimulation in the therapeutical algorithm of central sleep apnoea in heart…
Unilateral phrenic nerve stimulation in the therapeutical algorithm of central sleep apnoea in heart failurePurpose of review Central sleep apnoea (CSA) is highly prevalent in patients with heart failure and substantially impairs survival. If optimal cardiac treatment fails, alternative therapeutical options, including positive airway pressure (PAP) therapies, drugs or application of oxygen and carbon dioxide are considered to suppress CSA which interfere with the complex underlying pathophysiology….

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Medicine by Alexandros G. Sfakianakis

09:45

Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal…
Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal pain,Purpose of review Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this critical review will summarize recent findings concerning the clinical evaluation…

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Medicine by Alexandros G. Sfakianakis

09:44

Supportive and Palliative Care
Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal painPurpose of review Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this critical review will summarize recent findings concerning the clinical evaluation…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:44

Anaesthesiology
Comparison of a simplified nasal continuous positive airways pressure device with nasal cannula in obese patients undergoing colonoscopy during deep sedation: A randomised clinical trialBACKGROUND Continuous positive airways pressure (CPAP) with a CPAP machine and mask has been shown to be more effective at minimising hypoxaemia than other devices under deep sedation. However, the efficacy of a new and simple CPAP device for spontaneously breathing obese patients during colonoscopy is unknown. OBJECTIVE…

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Medicine by Alexandros G. Sfakianakis

09:43

Computer-Assisted Design and Manufacturing Assists Less Experienced Surgeons in Achieving Equivalent…
Computer-Assisted Design and Manufacturing Assists Less Experienced Surgeons in Achieving Equivalent Outcomes in Cranial Vault Reconstruction,Purpose: The purpose of this study was to assess whether long-term outcomes were equivalent between computer-assisted design and manufacturing (CAD/CAM) -assisted cranial vault reconstruction performed by an inexperienced surgeon, with fewer years of surgical experience, and traditional reconstruction performed by senior surgeons with many decades of experience….

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Medicine by Alexandros G. Sfakianakis

09:42

Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted…
Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted Rapid Orthodontics,Background: Corticotomy-assisted rapid orthodontics is a widely used method for speeding up conventional orthodontics. This study evaluates the effects of corticotomy alone, corticotomy combined with bone graft, and corticotomy with platelet-rich fibrin (PRF) on vestibular alveolar bone thickness in patients with class I malocclusion;compares the treatment time with a conventional…

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Medicine by Alexandros G. Sfakianakis

09:42

Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol…
Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol Granuloma With Intraoperative Video,With the development of minimally invasive endoscopic surgery and image-guided navigation systems, the endoscopic endonasal approach to petrous apex lesions has become more favorable. In this case, a petrous apex cholesterol granuloma was successfully treated with an endoscopic endonasal transpterygoid approach. A navigation system was used, and a contralateral…

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Medicine by Alexandros G. Sfakianakis

09:36

Radiologic Evaluation of Exiting Points of Supraorbital Region Neurovascular Bundles in Patients With…
Radiologic Evaluation of Exiting Points of Supraorbital Region Neurovascular Bundles in Patients With Migraine,Purpose: To reveal the presence and nature of exiting points of supraorbital region neurovascular structures and determine the distances of those structures to midline with computed tomography images by taking into account gender and sides in patients with migraine. Methods: The study was conducted retrospectively on computed tomography images of 70 migraine and 70 control patients with…

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Medicine by Alexandros G. Sfakianakis

09:36

Pediatric Cervicofacial Actinomycosis: Lessons From a Craniofacial Unit, Actinomycosis is a rare disease…
Pediatric Cervicofacial Actinomycosis: Lessons From a Craniofacial Unit,Actinomycosis is a rare disease that remains difficult to diagnose and manage. Prompted by 2 recent cases the authors sought evidence-based conclusions about best practice. A systematic review was conducted using standard PRISMA methodology. The study was registered prospectively (PROSPERO: CRD42018115064). Thirty-three children from 23 series are described. The mean age was 8 years (range 3–17). Fifty-five percent were female….

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Medicine by Alexandros G. Sfakianakis

09:30

Craniofacial Surgery
Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol Granuloma With Intraoperative VideoWith the development of minimally invasive endoscopic surgery and image-guided navigation systems, the endoscopic endonasal approach to petrous apex lesions has become more favorable. In this case, a petrous apex cholesterol granuloma was successfully treated with an endoscopic endonasal transpterygoid approach. A navigation system was used, and a contralateral…

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Medicine by Alexandros G. Sfakianakis

09:30

Tropical Medicine
Pharmacological and analytical aspects of artemisinin for malaria: Advances and challengesSravani Karri, Sanjay Sharma, Ginpreet KaurAsian Pacific Journal of Tropical Medicine 2019 12(8):339-346Malaria remains a major tropical health burden owing to the development of resistance and decreased sensitivity to the frequently used conventional antimalarial drugs. The drug like artemisinin possesses potent antimalarial activities, but has some limitations. Therefore, new strategies are to be implemented…

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Medicine by Alexandros G. Sfakianakis

09:29

Olfaction and quality of life in patients with nasal septal deviation treated with septoplasty Author…
Olfaction and quality of life in patients with nasal septal deviation treated with septoplastyAuthor links open overlay ,panel.KonstantinosValsamidisaAthanasiaPrintzaaKonstantinosTitelisbJannisConstantinidisaStefanosTriaridisaa1st Otolaryngology Department, Medical Dept, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreecebOtolaryngology Department, General Hospital Georgios Gennimatas, Ethnikis Amynis 41, 54635 Thessaloniki, GreeceReceived 11 June 2019, Available…

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Medicine by Alexandros G. Sfakianakis

09:22



Recent advances in musculoskeletal local drug delivery, Publication date: 15 July 2019 Source: Acta…
Recent advances in musculoskeletal local drug delivery,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Shichao Zhang, Malcolm Xing, Bingyun LiAbstractMusculoskeletal disorders are a significant burden on the global economy and public health. Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise of enhancing the repair of degenerated and injured musculoskeletal tissues. Ideally, drug delivery should have the ability to directly deliver…

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Medicine by Alexandros G. Sfakianakis

09:21



Porous PolyHIPE microspheres for protein delivery from an injectable bone graft, Publication date:…
Porous PolyHIPE microspheres for protein delivery from an injectable bone graft,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Michael Whitely, Gabriel Rodriguez-Rivera, Christina Waldron, Sahar Mohiuddin, Stacy Cereceres, Nicholas Sears, Nicholas Ray, Elizabeth Cosgriff-HernandezAbstractDelivery of osteoinductive factors such as bone morphogenetic protein 2 (BMP-2) has emerged as a prominent strategy to improve regeneration in bone grafting procedures. However, it…

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Medicine by Alexandros G. Sfakianakis

09:21



Biodegradable polymerized simvastatin stimulates bone formation, Publication date: 15 July 2019 Source: Acta…
Biodegradable polymerized simvastatin stimulates bone formation,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Nandakumar Venkatesan, A.D. Thilanga Liyanage, Jaime Castro-Núñez, Theodora Asafo-Adjei, Larry L. Cunningham, Thomas D. Dziubla, David A. PuleoAbstractPrevious research from our labs demonstrated the synthesis of polymerized simvastatin by ring-opening polymerization and slow degradation with controlled release of simvastatin in vitro. The objective of the…

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Medicine by Alexandros G. Sfakianakis

09:20

A computational study of the dual effect of intermittent and continuous administration of parathyroid…
A computational study of the dual effect of intermittent and continuous administration of parathyroid hormone on bone remodeling,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Yu Zhao, Guigen ZhangAbstractBone remodeling is a process known to be governed by constant interactions between osteoblast and osteoclast through complex pathway networks mediated by signaling factors. Experimental studies show that intermittent and continuous administration of PTH/PTHrP led to…

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Medicine by Alexandros G. Sfakianakis

09:20



Acta Biomaterialia
Editorial BoardPublication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s):Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat kneePublication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Thanh N. Doan, Fabrice C. Bernard, Jay M. McKinney, J. Brandon Dixon, Nick J. WillettAbstractClearance of particles from the knee is an essential mechanism to maintain healthy joint homeostasis and critical…

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Medicine by Alexandros G. Sfakianakis

09:19

The Prognostic Usefulness of The Lactate/Albumin Ratio For Predicting Clinical Outcomes In Out-Of-Hospital…
The Prognostic Usefulness of The Lactate/Albumin Ratio For Predicting Clinical Outcomes In Out-Of-Hospital Cardiac Arrest: A Prospective, Multicentre Observational Study (KoCARC Study)Background and Purpose: We aimed to evaluate the lactate/albumin ratio (LAR) to identify its significance as a prognostic marker for favourable neurologic outcome and survival in patients with return of spontaneous circulation after out-of-hospital cardiac arrest (OHCA). Based on the LAR and multiple parameters, we…

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Medicine by Alexandros G. Sfakianakis

09:18

Influence of Hyperglycemia During Different Phases of Ischemic Preconditioning on Cardioprotection—A…
Influence of Hyperglycemia During Different Phases of Ischemic Preconditioning on Cardioprotection—A Focus On Apoptosis and Aggregation of Granulocytes,Background: Ischemic preconditioning (IPC) protects the myocardium against ischemia/reperfusion injury. Evidence suggests that hyperglycemia inhibits IPC-induced cardioprotection. The effects of hyperglycemia initiated during different phases of IPC on myocardial injury were characterized with emphasis on apoptosis and aggregation of polymorphonuclear…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:18

Right ventricular function and long-term outcome in sepsis: a retrospective cohort study, Background:…
Right ventricular function and long-term outcome in sepsis: a retrospective cohort study,Background: Sepsis-related myocardial dysfunction is associated with impaired outcome. Traditionally, in this setting the main focus has been on left ventricular performance. Currently, specific knowledge on the prognostic importance of right ventricular dysfunction is scarce. The aim of this study was to determine whether right ventricular ejection fraction (RVEF) is predictive of long-term mortality in sepsis….

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Medicine by Alexandros G. Sfakianakis

09:17

Shock
Lactic Acidosis and The Role of Sodium Bicarbonate: A Narrative OpinionLactic acidosis occurs commonly and can be a marker of significant physiologic derangements. However what an elevated lactate level and acidemia connotes and what should be done about it is subject to inconsistent interpretations. This review examines the varied etiologies of lactic acidosis, the physiologic consequences, and the known effects of its treatment with sodium bicarbonate. Lactic acidosis is often assumed to be a marker…

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Medicine by Alexandros G. Sfakianakis

09:16

Investigational New Drugs
Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl- XLhttps://doi.org/10.1016/j.juro.2010.07.035Correction to: Phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab in metastatic pancreatic adenocarcinomaThe authors would like to note an error in Figures 1 and 2 of this paper. The graph in Figure 1 incorrectly reflected the overall survival (OS), when it should have displayed the…

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Medicine by Alexandros G. Sfakianakis

09:15

“Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling” Abstract We…
“Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling”AbstractWe have explored the fundamental biological processes by which complex carbohydrates expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell adhesion and signaling. We have also explored processes by which animal pathogens, such as viruses, bacteria, and parasites adhere to glycans of animal cells and initiate disease. Glycans important in cell signaling and adhesion,…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:14

Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarker Abstract…
Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarkerAbstractGangliosides altered during the pathological conditions and particularly in cancers. Here, we aimed to profile the gangliosides in breast cancer serum and propose potential biomarkers. LC-FTMS method was first used to identify all the ganglioside species in serum, then LC-MS/MS-MRM method was employed to quantitate the levels of gangliosides in serum from healthy volunteers and patients with benign…

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Medicine by Alexandros G. Sfakianakis

09:13

Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response, Abstract Even though a…
Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response,AbstractEven though a vaccine that targets tumor-associated carbohydrate antigens on epithelial carcinoma cells presents an attractive therapeutic approach, relatively poor immunogenicity limits its development. In this study, we investigated the immunological activity of a fluoro-substituted Sialyl-Tn (F-STn) analogue coupled to the non-toxic cross-reactive material of diphtheria toxin197 (CRM197). Our results indicate that…

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Medicine by Alexandros G. Sfakianakis

09:13



Glycoconjugate Journal
The international Glycoconjugate organization awardsThe International Glycoconjugate Organization AwardsGlyco25, XXV International Symposium on Glycoconjugates“Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling”AbstractWe have explored the fundamental biological processes by which complex carbohydrates expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell adhesion and signaling. We have also explored processes by which animal…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:12

Mepilex Border Sacrum and Heel Dressings for the Prevention of Pressure Ulcers: A NICE Medical Technology…
Mepilex Border Sacrum and Heel Dressings for the Prevention of Pressure Ulcers: A NICE Medical Technology Guidance,AbstractMepilex Border Sacrum and Heel dressings are self-adherent, multilayer foam dressings designed for use on the heel and sacrum aiming to prevent pressure ulcers. The dressings are used in addition to standard care protocols for pressure ulcer prevention. The National Institute for Health and Care Excellence (NICE) selected Mepilex Border Sacrum and Heel dressings for evaluation….

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Medicine by Alexandros G. Sfakianakis

09:08

Applied Health Economics and Health Policy
Authors’ Reply to Hussain et al.: “Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations”Comment on: “Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations”Applying an Implementation Framework to the Use of Evidence from Economic Evaluations in Making Healthcare DecisionsAbstractBackground and ObjectiveThere is a need for the application of theory in understanding the use of evidence from economic evaluations in healthcare decision…

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Medicine by Alexandros G. Sfakianakis

09:07

Orthopaedic and Trauma Surgery
Investigation of thermally induced damage to surrounding nerve tissue when using curettage and cementation of long bone tumours, modelled in cadaveric porcine femursAbstractIntroductionCurettage with cement augmentation is a technique used in the treatment of bone tumours. Thermal energy released during the cement polymerisation process can damage surrounding tissues. This study aims to record temperature changes at various sites on and around bone during the cementing process. We hypothesised that…

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Medicine by Alexandros G. Sfakianakis

09:06

Urolithiasis
Role of ‘dusting and pop-dusting’ using a high-powered (100 W) laser machine in the treatment of large stones (≥ 15 mm): prospective outcomes over 16 monthsAbstractUreteroscopy and laser stone fragmentation (URSL) has had recent advancements with the more powerful laser systems with the ability to ‘dust’ and ‘pop-dust’ the stone. We wanted to look at the outcomes of this method for large stones (≥ 15 mm) using our new 100 W holmium laser. Over a period of 16 months (January 2017–April 2018), 50 patients…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:05

Is oxidized low-density lipoprotein the connection between atherosclerosis, cardiovascular risk and…
Is oxidized low-density lipoprotein the connection between atherosclerosis, cardiovascular risk and nephrolithiasis?AbstractNephrolithiasis is considered a systemic disease. A link has been established between nephrolithiasis, cardiovascular disease (CVD), the metabolic syndrome and atherosclerosis. A significant correlation has been found between the high levels of oxidized low-density lipoprotein (oxLDL) and CVD and atherosclerosis, including coronary and femoral artery disease. To the best of…

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Medicine by Alexandros G. Sfakianakis

09:05

Slavery, Indenture and the Development of British Industrial Capitalism, Mark Harvey
Slavery, Indenture and the Development of British Industrial Capitalism, Mark Harvey

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:04

Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland, AbstractPurpose…
Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland,AbstractPurposeTo survey adenoid cystic carcinoma of lacrimal glands in Asian population and investigate the predictability in prognosis following the 8th edition American Joint Committee on Cancer (AJCC) staging guideline.Study designRetrospective study.MethodsThe clinical entities and surgical outcomes of the patients who were histologically confirmed with a diagnosis of lacrimal adenoid cystic carcinoma in…

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Medicine by Alexandros G. Sfakianakis

09:04

Robot-assisted stereotactic brainstem biopsy in children: prospective cohort study Abstract Tumours…
Robot-assisted stereotactic brainstem biopsy in children: prospective cohort studyAbstractTumours located within the brainstem comprise approximately a tenth of all paediatric brain tumours. Surgical biopsy of these tumours is technically challenging and has historically been associated with considerable risk. To this end, robot-assisted surgery theoretically allows for increased accuracy and precision. In this study we report our experience using the Neuromate robot (Renishaw, Gloucestershire, UK)…

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Medicine by Alexandros G. Sfakianakis

09:01

Categories We Live by
: The Construction of Sex, Gender, Race, and Other Social Categories, by Ásta Elizabeth Barnes; Matthew Andler

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:01

Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral…
Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral robotic surgery (TORS)AbstractAdvances in three-dimensional (3D) video recording and playback have expanded the availability of stereoscopic videos for consumption with specialized televisions, computer monitors, and virtual reality (VR) headsets. The built-in stereoscopic vision of the da vinci surgical system (Intuitive Surgical, Sunnyvale, CA) enables the recording of both camera views. However,…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

09:00

Robotic harvesting of the omental flap: a case report and mini-review of the use of robots in reconstructive…
Robotic harvesting of the omental flap: a case report and mini-review of the use of robots in reconstructive surgeryAbstractThis study describes the robotic harvesting of a free omental flap. The patient was a 58-year-old man who had undergone several previous operations due to osteomyelitis caused by trauma. There was a non-healing wound and purulent discharge in the distal pretibial region. The flap was harvested based on the right gastroepiploic artery using robotic facilities only. The flap was…

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Medicine by Alexandros G. Sfakianakis

09:00

Robotic Surgery
Should we use virtual simulators for surgical resident selection?New perspectives about the role of robot-assisted surgery for the treatment of endometriosisRobot assisted intra-corporeal ileocalicostomy ureteral substitution for complex uretero-pelvic junction obstruction: a novel and feasible innovationAbstractA 33-year-old female presented to the emergency department of our hospital with urosepsis and hematuria with clot retention secondary to a complicated pyelolithotomy for left-sided pelvic…

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Medicine by Alexandros G. Sfakianakis

09:00

Kavita Sivaramakrishnan, As the World Ages: Rethinking a Demographic Crisis, Hyung Wook Park Michelle…
Kavita Sivaramakrishnan, As the World Ages: Rethinking a Demographic Crisis, Hyung Wook Park Michelle L. McClellan, Lady Lushes: Gender, Alcoholism, and Medicine in Modern America Stephen E Mawdsley Dóra Vargha, Polio Across the Iron Curtain: Hungary’s Cold War with an Epidemic Stephen E Mawdsley

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Medicine by Alexandros G. Sfakianakis

08:59

Feminisms Anna Watz
Feminisms Anna Watz

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Medicine by Alexandros G. Sfakianakis

08:58

Beer? Over here!
Examining attentional bias towards alcoholic and appetitive stimuli in a visual search eye-tracking taskAbstractRationaleExperimental tasks that demonstrate alcohol-related attentional bias typically expose participants to single-stimulus targets (e.g. addiction Stroop, visual probe, anti-saccade task), which may not correspond fully with real-world contexts where alcoholic and non-alcoholic cues simultaneously compete for attention. Moreover, alcoholic stimuli are rarely matched to other appetitive non-alcoholic…

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Medicine by Alexandros G. Sfakianakis

08:58

Psychopharmacology
Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male miceAbstractRationaleApproximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD.ObjectiveTo investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of ethanol.MethodsThe effects of DOI were examined…

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Medicine by Alexandros G. Sfakianakis

08:58



Macromolecular Research
Effect of the Monomer Ratio on the Properties of Melt-Polymerized PolycarbonateAbstractIn this study, the effects of bisphenol A (BPA) and diphenyl carbonate (DPC) molar ratio, on the properties of melt-polymerized polycarbonate (PC) were investigated. The molecular size distribution theory proposed by Flory was applied, to melt polymerization of PC to predict physical properties, affected by the molar ratio of BPA and DPC. A terminal OH group affected the viscosity of PC at high temperatures, leading…

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Medicine by Alexandros G. Sfakianakis

08:57

Effectiveness of Facebook Groups to Boost Participation in a Parenting Intervention, Abstract Although…
Effectiveness of Facebook Groups to Boost Participation in a Parenting Intervention,AbstractAlthough family-based prevention programs have been shown to be effective at reducing adolescent substance use, it is often difficult and costly to recruit and retain parents in programs administered in person. The current study tested whether program engagement and parenting practices could be improved by offering parents in a self-directed family program access to a private Facebook group. Parents of middle…

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Medicine by Alexandros G. Sfakianakis

08:56

Prevention Science
Correction to: A Cost Analysis of School-Based Lifestyle InterventionsIn the article, ‘A Cost Analysis of School-Based Lifestyle Interventions’, we calculated the societal costs of two school-based lifestyle interventions: ‘the Healthy Primary School of the Future’ and ‘the Physical Activity School’.Effectiveness of Facebook Groups to Boost Participation in a Parenting InterventionAbstractAlthough family-based prevention programs have been shown to be effective at reducing adolescent substance use,…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

08:56

Protein & Cell
Correction to: Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrityIn the original publication, the label of Fig. 2C should be read as “GFAP/lectin/DAPI” not “DMP1/GFAP/lectin/DAPI”.Professor Tafu Yu: an eminent agricultural scientist and outstanding educator of our nationDeveloping potent PROTACs tools for selective degradation of HDAC6 proteinA miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1AbstractsThe…

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Medicine by Alexandros G. Sfakianakis

08:55

Low-frequency ventilatory oscillations in hypoxia are a major contributor to the low-frequency component…
Low-frequency ventilatory oscillations in hypoxia are a major contributor to the low-frequency component of heart rate variabilityAbstractPurposeHeart rate variability (HRV) may be influenced by several factors, such as environment (hypoxia, hyperoxia, hypercapnia) or physiological demand (exercise). In this retrospective study, we tested the hypothesis that inter-beat (RR) intervals in healthy subjects exercising under various environmental stresses exhibit oscillations at the same frequency than…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

08:54

Vibration as an adjunct to exercise: its impact on shoulder muscle activation, AbstractPurpose There…
Vibration as an adjunct to exercise: its impact on shoulder muscle activation,AbstractPurposeThere is an interest within elite sport in understanding the impact of a vibrating platform as an adjunct to exercise in the training and rehabilitation of throwing athletes. However, there has been no comprehensive evaluation of its impact on the rotator cuff muscles or its effect on the timing of shoulder muscle recruitment more globally.MethodsTwenty healthy participants were recruited with EMG recorded…

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Medicine by Alexandros G. Sfakianakis

08:53

Leg- vs arm-cycling repeated sprints with blood flow restriction and systemic hypoxia AbstractPurpose…
Leg- vs arm-cycling repeated sprints with blood flow restriction and systemic hypoxiaAbstractPurposeThe aim was to compare changes in peripheral and cerebral oxygenation, as well as metabolic and performance responses during conditions of blood flow restriction (BFR, bilateral vascular occlusion at 0% vs. 45% of resting pulse elimination pressure) and systemic hypoxia (~ 400 m, FIO2 20.9% vs. ~ 3800 m normobaric hypoxia, FIO2 13.1 ± 0.1%) during repeated sprint tests to exhaustion (RST) between leg-…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

08:52

Bone mineral density, energy availability, and dietary restraint in collegiate cross-country runners…
Bone mineral density, energy availability, and dietary restraint in collegiate cross-country runners and non-running controlsAbstractPurposeWeight-bearing activities such as running have been shown to be osteogenic. However, investigations have also shown that running may lead to site-specific deficiencies in bone mineral density (BMD) as well as overall low BMD. The purpose of this investigation was to evaluate and compare the BMD of female and male collegiate cross-country runners with non-running…

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Medicine by Alexandros G. Sfakianakis

08:52

Cold-water immersion blunts and delays increases in circulating testosterone and cytokines post-resistance…
Cold-water immersion blunts and delays increases in circulating testosterone and cytokines post-resistance exerciseAbstractIntroductionCold-water immersion (CWI) is often used to promote recovery by reducing exercise-induced muscle damage, soreness, and inflammation. However, recent reports have cautioned that CWI may attenuate the adaptive response to resistance training.PurposeTo determine the effect of post resistance-exercise CWI on circulating free testosterone (T) and cytokine (IL-6 and TNF-α)…

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Medicine by Alexandros G. Sfakianakis

08:52

Applied Physiology
Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young menAbstractIntroductionRetrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO2) induced via 30 min of external compression.MethodsParticipants included 11 exercise trained…

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Medicine by Alexandros G. Sfakianakis

08:51

Business and Psychology
Enacting Effective Mentoring Behaviors: Development and Initial Investigation of the Cuboid of MentoringAbstractOur understanding of how to maximize the benefits of mentoring relationships for employee development has been limited by a vague understanding of what effective mentors are actually doing and how they are doing it. To begin to remedy this, we conducted one qualitative interview study of well-respected mentors to uncover the breadth and detail of their behaviors, and one quantitative study…

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Medicine by Alexandros G. Sfakianakis

08:50

Molecular Breeding
Correction to: Genetic analysis and gene mapping of the orange flower trait in Chinese cabbage ( Brassica rapa L.)The original article unfortunately contains an incorrect supplementary materials.QTL mapping in Vigna radiata × Vigna umbellata population uncovers major genomic regions associated with bruchid resistanceAbstractMungbean (Vigna radiata), genus Vigna, is an economically important legume crop that is valued for its protein-rich dry seeds. However, bruchid infestation causes severe threat…

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Medicine by Alexandros G. Sfakianakis

08:49



Method for Visible Light‐Induced Photocatalytic Degradation of Methylparaben in Water Using Nanostructured…
Method for Visible Light‐Induced Photocatalytic Degradation of Methylparaben in Water Using Nanostructured Ag/AgBr@m‐WO3,Mohammed A. Suliman, Mohammed A. Gondal, Mohamed A. Dastageer, Gaik‐Khuan Chuah, Chanbasha BasheerVersion of Record online: 10 July 2019Ag nanoparticles loaded AgBr‐mesoporous‐WO3 composite was synthesized, characterized and used as a photocatalyst in conjunction with visible light radiation for the photocatalytic degradation of methylparaben in water. This nanocomposites showed…

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Medicine by Alexandros G. Sfakianakis

08:48



Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea ClimatotherapyMichael…
Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea ClimatotherapyMichael Brandwein, Garold Fuks, Avigail Israel, Fareed Sabbah, Emmilia Hodak, Amir Szitenberg, Marco Harari, Droron Steinberg, Zvi Bentwich, Noam Shental, Shiri MeshnerVersion of Record online: 10 July 2019 Microbiome dysbiosis is a hallmark of atopic dermatitis and has been shown to be change following several different treatment modalities. Dead Sea climatotherapy is a well‐established therapeutic modality…

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Medicine by Alexandros G. Sfakianakis

08:47



Medical Applications of Rose Bengal‐ and Riboflavin‐Photosensitized Protein CrosslinkingRobert W. Redmond, Irene…
Medical Applications of Rose Bengal‐ and Riboflavin‐Photosensitized Protein CrosslinkingRobert W. Redmond, Irene E. KochevarVersion of Record online: 10 July 2019 Research on the many potential surgical applications of photosensitized crosslinking of tissue proteins and on the underlying photochemical mechanisms is reviewed. Largely used to close wounds or reattach tissues, protein photocrosslinking stiffens and strengthens tissues, decreases inflammatory responses and facilitates tissue bioengineering….

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Medicine by Alexandros G. Sfakianakis

08:46



Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in…
Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of ChicksLiang Yue, Xiaojing Qin, Xinfeng Liu, Zixu Wang, Yulan Dong, Yaoxing Chen, Jing CaoVersion of Record online: 13 July 2019 Monochromatic green light promotes the secretion of plasma melatonin. Melatonin influences the expression of Pit‐1 and the secretion of growth hormone in the adenohypophysis cells through melatonin receptor Mel1b and Mel1c.

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Medicine by Alexandros G. Sfakianakis

08:46



Recurrent Xanthelasmas Treated With Intralesional Deoxycholic Acid , Patel, Jigar MD; Ranjit-Reeves, Roshni MD; Woodward, Julie MD Dermatologic Surgery: March 18, 2019 – Volume Publish Ahead of Print – Issue – p doi: 10.1097/DSS.0000000000001936

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Medicine by Alexandros G. Sfakianakis

08:29



Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large Lipoma
Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large Lipoma

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Medicine by Alexandros G. Sfakianakis

08:28



Introducing the L-Lift—A Novel Approach to Treat Age-Related Facial Skin Ptosis Using A Collagen Stimulator Hexsel, Doris MD; Hexsel, Camile L. MD; Cotofana, Sebastian MD, PhD Dermatologic Surgery: July 09, 2019 – Volume Publish Ahead of Print – Issue – p doi: 10.1097/DSS.0000000000002015

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Medicine by Alexandros G. Sfakianakis

08:25

Cutaneous Leiomyosarcoma: A SEER Database Analysis, BACKGROUND Cutaneous leiomyosarcoma is a rare…
Cutaneous Leiomyosarcoma: A SEER Database Analysis,BACKGROUND Cutaneous leiomyosarcoma is a rare dermal neoplasm usually arising from the pilar smooth muscle. It is considered a relatively indolent neoplasm, and there is debate whether designation as sarcoma is appropriate. Owing to some conflicting data in the literature, however, its behavior warrants further clarification. OBJECTIVE To determine the clinical behavior and demographic and pathologic characteristics of cutaneous leiomyosarcoma. MATERIALS…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

08:24



Safety of Subcutaneous Infiltration of Carbon Dioxide (Carboxytherapy) for Abdominal Fat Reduction:…
Safety of Subcutaneous Infiltration of Carbon Dioxide (Carboxytherapy) for Abdominal Fat Reduction: A Pilot Study,

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

08:23

Internal Jugular Vein Thrombosis, Yi Lee; Waqas J. Siddiqui.Author Information AuthorsYi Lee1; Waqas…
Internal Jugular Vein Thrombosis,Yi Lee; Waqas J. Siddiqui.Author InformationAuthorsYi Lee1; Waqas J. Siddiqui2.Affiliations1 Chung Shan Medical University2 Drexel UniversityLast Update: April 29, 2019.Go to:IntroductionThe internal jugular vein (IJV) originates at the jugular foramen, tracks down to the lateral neck and ends at the brachiocephalic vein. The IJV is one of the four components of the carotid sheath, along with the common carotid artery, internal carotid artery, the vagus nerve, and…

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Medicine by Alexandros G. Sfakianakis

08:22

Aesthetic Outcomes of Nasal Burow’s Grafts With Interdomal Sutures After Mohs Micrographic Surgery BACKGROUND…
Aesthetic Outcomes of Nasal Burow’s Grafts With Interdomal Sutures After Mohs Micrographic SurgeryBACKGROUND Post-Mohs reconstruction of distal nasal defects is challenging. Many repair options exist, each with advantages and disadvantages. Utilization of a Burow’s graft in combination with manipulation of the underlying nasal cartilages with interdomal sutures is an underreported yet effective repair option. OBJECTIVE To present the authors’ experience with Burow’s grafts facilitated by interdomal…

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Medicine by Alexandros G. Sfakianakis

08:22

Primary Cutaneous Umbilical Melanoma: The Michigan Experience BACKGROUND Primary cutaneous umbilical…
Primary Cutaneous Umbilical Melanoma: The Michigan ExperienceBACKGROUND Primary cutaneous umbilical melanoma is rare. Thorough information regarding its characteristics and treatment, including use of sentinel lymph node biopsy (SLNB) staging, is difficult to obtain. The unique anatomy of the umbilicus adds to the complexity of diagnosing and treating melanoma at this site. OBJECTIVE To improve understanding of diagnosis and treatment of primary cutaneous umbilical melanoma through presenting 7 new…

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Medicine by Alexandros G. Sfakianakis

08:22

Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian…
Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian tube,Publication date: August 2019Source: Auris Nasus Larynx, Volume 46, Issue 4Author(s): Ryoukichi Ikeda, Hiromitsu Miyazaki, Masahiro Morita, Daisuke Yamauchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu KobayashiAbstractObjectivesThe patulous Eustachian tube (PET) and superior semicircular canal dehiscence syndrome (SCDS) have similarity in their symptoms and similar effects caused by positional…

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Medicine by Alexandros G. Sfakianakis

08:15



The New England Journal of Medicine
IMAGES IN CLINICAL MEDICINEJUL 11, 2019“Double Tongue” Appearance in Ludwig’s AnginaMohamad I. and Narayanan M.S.|N Engl J Med 2019; 381:163IMAGES IN CLINICAL MEDICINEJUL 11, 2019Whooping Cough in a Young InfantHillier D.|N Engl J Med 2019; 381:e4IMAGES IN CLINICAL MEDICINEJUL 04, 2019Enterobius vermicularis (Pinworm) InfectionKang W.-H. and Jee S.-C.|N Engl J Med 2019; 381:e1IMAGES IN CLINICAL MEDICINEJUL 04, 2019Pneumoperitoneum from a Gastric PerforationMasson A. and Cheron G.|N Engl J Med 2019;…

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Medicine by Alexandros G. Sfakianakis

08:12

The New England Journal of Medicine
PERSPECTIVEPrimary Care First — Is It a Step Back?L.L. Sessums, S. Basu, and B.E. LandonDOI: 10.1056/NEJMp1906593 | July 17, 2019Case Studies in Social Medicine: The Right and Left Hands of the State — Two Patients at Risk of DeportationA. Berlin, V. Koski-Karell, K.R. Page, and S. PolkN Engl J Med 2019;381:197-201Sodium-Intake Reduction and the Food IndustryJ.E. Henney, J.A. O’Hara III, and C.L. TaylorN Engl J Med 2019;381:201-203 | Published Online May 29, 2019A “Never Event” That Could Kill MillionsM….

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Medicine by Alexandros G. Sfakianakis

08:09



IMAGES IN CLINICAL MEDICINE, Mucosal Neuromas, Andrew R. Scott, M.D., and Rebecca A. Compton, M.D….
IMAGES IN CLINICAL MEDICINE, Mucosal Neuromas, Andrew R. Scott, M.D., and Rebecca A. Compton, M.D. A 7-year-old boy presented to the pediatric otolaryngology clinic with a 3-year history of multiple firm, painless, slow-growing nodules on his tongue. He had a history of mild developmental delay, and a physical examination showed a high arched palate and marfanoid habitus. Excisional biopsies of the lesions on the tongue revealed mucosal neuromas. Multiple endocrine neoplasia type 2B was suspected….

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Medicine by Alexandros G. Sfakianakis

08:08

Teaching Topic, A Woman with Weakness, Dark Urine, and Dysphagia, CASE RECORDS OF THE MASSACHUSETTS…
Teaching Topic,A Woman with Weakness, Dark Urine, and Dysphagia,CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITALCase 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and DysphagiaM.W. Freeman and Others Although rhabdomyolysis is relatively easy to diagnose, the underlying cause of the muscle breakdown is less straightforward to identify.Clinical Pearls What are the major causes of rhabdomyolysis in the United States?Most cases of rhabdomyolysis in the United States are caused by trauma…

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Medicine by Alexandros G. Sfakianakis

08:06

Drug-Induced Liver Injury — Types and Phenotypes, J.H. Hoofnagle and E.S. Björnsson The diagnosis…
Drug-Induced Liver Injury — Types and Phenotypes,J.H. Hoofnagle and E.S. Björnsson The diagnosis of drug-induced liver injury is particularly challenging, since it is based largely on exclusion of other causes. Drug-induced liver injury is the most frequent cause of acute liver failure in most Western countries, accounting for more than half of cases.Clinical Pearls Do new drugs account for most of the top 10 causes of drug-induced liver injury?A striking finding is that 9 of the top 10 causes…

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Medicine by Alexandros G. Sfakianakis

08:05



The Back Letter
Current IssuePrevious Articles & IssuesAbout the JournalSearch JournalTrusted Websites Denying Patients and the General Public Accurate Information About Back Pain TreatmentsObesity, Pain, and the Opioid CrisisSenseless Obstacles to a Lifesaving Opioid Addiction MedicationPutting a Price Tag on Physician Burnout—A Major Hazard for Back Care ProfessionsDramatic Reduction in Postoperative Opioid Use With a Novel Pain Management ProgramFemale Spine Surgeons Need More Help at Home Lest They Risk…

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Medicine by Alexandros G. Sfakianakis

08:04



Comparison of CT and MRI in Diagnosis of Laryngeal Carcinoma with Anterior Vocal Commissure Involvement …
Comparison of CT and MRI in Diagnosis of Laryngeal Carcinoma with Anterior Vocal Commissure Involvement ,Sci Rep. 2016; 6: 30353.Published online 2016 Aug 2. doi: 10.1038/srep30353PMCID: PMC4969597PMID: 27480073,Jian-hui Wu,1,2 Jing Zhao,1,* Zeng-hong Li,3 Wei-qiang Yang,4 Qi-hong Liu,5 Zhi-yun Yang,6 Bing Liao,7Xiao-ling Li,8 Bin Wang,1 Hao Qin,3 Jie Luo,1 Ke-xing Lv,1,* Wei-ping Wen,a,1 and Wen-bin Leib,1Author information Article notes Copyright and License information Disclaimer1Otorhinolaryngology…

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Medicine by Alexandros G. Sfakianakis

08:02



Dermatology Nurses Association
Friendship in Dermatology Nurses, Personal Growth, and LeadershipNo abstract availableDermatology Nurse Practitioner Practice AnalysisNo abstract availableSkin Cancer Knowledge and Prevention Practices Among Young Adult AthletesThe Skin Cancer Foundation defines skin cancer as uncontrolled growth of abnormal skin cells (The Skin Cancer Foundation, 2016b). Skin cancer risk factors include ultraviolet radiation and sun exposure (American Cancer Society, 2016b). Young adult outdoor athletes are frequently…

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Medicine by Alexandros G. Sfakianakis

07:55

Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical…
Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical Trial,Background: Most patients undergoing surgery for the treatment of a distal radial fracture are treated in a day-surgery setting and are given either general anesthesia (GA) or regional anesthesia (RA). The main purpose of this study was to investigate the impact of the anesthesia method on patients’ postoperative opioid consumption during the first 3 days following surgery. Methods: This…

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Medicine by Alexandros G. Sfakianakis

07:53



Geriatric Physical Therapy
Editor’s Message: Journal Format Changes, Journal Status, and Reviewer Appreciation 2019No abstract availableAcademy of Geriatric Physical Therapy Inaugural Carole B. Lewis Lecture Award Address to the Membership at the Combined Sections Meeting Washington, DC January 24, 2019No abstract availableRisk Factors and Number of Falls as Determinants of Quality of Life of Community-Dwelling Older AdultsBackground and Purpose: In older adults, the psychological impact and effects related to the loss of…

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Medicine by Alexandros G. Sfakianakis

07:52



Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty:…
Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty: An Analysis of 11,738 CasesBackground: Povidone-iodine (PI) irrigation is often used prior to wound closure in total joint arthroplasty, but there are limited reports evaluating its efficacy in decreasing joint infections. The goal of this study was to compare the rate of any reoperation for infection (both superficial and deep) in primary total hip arthroplasty (THA) and primary total knee arthroplasty…

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Medicine by Alexandros G. Sfakianakis

07:52

Intraluminal Pulmonary Vein Stenosis in Children: A “New” Lesion, Pulmonary vein stenosis (PVS) is…
Intraluminal Pulmonary Vein Stenosis in Children: A “New” Lesion,Pulmonary vein stenosis (PVS) is a rare disorder that leads to progressive narrowing of the extrapulmonary veins. PVS has been reported in both children and adults and in its worse iteration leads to pulmonary hypertension, right ventricular failure, and death. Multiple etiologies of PVS have been described in children and adults. This review will focus on intraluminal PVS in children. Intraluminal PVS has an estimated incidence ranging…

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Medicine by Alexandros G. Sfakianakis

07:50



Anesthesia & Analgesia
In Search of Solutions for Chronic Pain: A Meta-analysis of Ketamine InfusionsNo abstract availableHow Low Can You Go: Mechanical Ventilation Over TimeNo abstract availableClear Study Aims and Hypotheses in a Research PaperNo abstract availablePigs and Paradigms: Stop Using Swine to Study Lipid ResuscitationNo abstract availableErector Spinae Block: A Magic Bullet for Postoperative Analgesia?No abstract availableOlder Adult With Cognitive Impairment Undergoing Ambulatory Surgery: New Epidemiological…

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Medicine by Alexandros G. Sfakianakis

07:49



Ameloblastic fibroma mimicking dentigerous cyst: A diagnostic dilemma Kiran C Khande1, Husain J Mograwala2, Rajshekhar…
Ameloblastic fibroma mimicking dentigerous cyst: A diagnostic dilemmaKiran C Khande1, Husain J Mograwala2, Rajshekhar C Halli2, Manjula A Hebbale31 Department of Oral and Maxillofacial Surgery, Shri Saibaba Hospital, Shirdi, Maharashtra, India2 Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India3 Department of Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India Abstract Ameloblastic…

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Medicine by Alexandros G. Sfakianakis

07:48



A rare case of mucoepidermoid carcinoma of parotid with mandibular metastasis Jitendra Kumar Diwakar1, Arjun…
A rare case of mucoepidermoid carcinoma of parotid with mandibular metastasisJitendra Kumar Diwakar1, Arjun Agarwal2, Cheena Garg3, KY Giri1, Ramakant Dandriyal1, Geetika Kumar41 Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India2 Department of Surgical Oncology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India3 Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India4 Department…

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Medicine by Alexandros G. Sfakianakis

07:48



Preliminary report of a true nasomaxillary infantile fibrosarcoma: Single-modality management and 2-year…
Preliminary report of a true nasomaxillary infantile fibrosarcoma: Single-modality management and 2-year follow-upNaveenkumar Jayakumar1, Veerabahu Rathnaprabhu2, Singaravelu Ramesh31 Department of Oral and Maxillofacial Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India2 Department of Paediatric Dentistry, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India3 Department of Paediatric Anaesthesiology, Kanchi Kamakoti Childs Trust Hospital,…

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Medicine by Alexandros G. Sfakianakis

07:47



Squamous cell carcinoma of lower lip reconstructed with bilateral fan flap Bhatt D Supreet1, Semmia…
Squamous cell carcinoma of lower lip reconstructed with bilateral fan flapBhatt D Supreet1, Semmia Mathivanan2, Mustafa I Merchant3, Niranjan S Patil41 Department of Head and Neck Oncology, Gujarat Cancer Research Institute, Ahmedabad, India2 Department of Oral and Maxilofacial Surgery, Chettinad Dental College and Research Institute, Kancheepuram, India3 Deparment of Surgical Oncology, Basil Onco Care, Surat, India4 Department of Maxillofacial Surgery, (Dental Specialty) Bombay Hospital, Mumbai,…

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Medicine by Alexandros G. Sfakianakis

07:46



Management of a penetrating orbital trauma from an unusual foreign body with associated eye injury…
Management of a penetrating orbital trauma from an unusual foreign body with associated eye injuryMartín Fernandez.Ferro1, Marta Fernández-Fernández2, Jacinto Fernández-Sanromán1, Alberto Costas-López1, Annahys López-Betancourt11 Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain2 Department of Ophthalmology, Povisa Hospital, Vigo, Pontevedra, SpainCorrespondence Address:Dr. Martín Fernandez.FerroDepartment of Oral and Maxillofacial Surgery, Rúa Salamanca 5, 36211…

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Medicine by Alexandros G. Sfakianakis

07:46

Maxillofacial Surgery
Management of a penetrating orbital trauma from an unusual foreign body with associated eye injuryMartín Fernandez.Ferro, Marta Fernández-Fernández, Jacinto Fernández-Sanromán, Alberto Costas-López, Annahys López-BetancourtHoloprosencephaly with clefts: Data of 85 patients, treatment and outcome: Part 1: History, subdivisions, and data on 85 holoprosencephalic cleft patientsEngela M Honey, Kurt W Bütow, Roger Arthur ZwahlenHoloprosencephaly with clefts: Data of 85 patients, treatment, and outcome:…

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Medicine by Alexandros G. Sfakianakis

07:44

Enjoying Music With Cochlear Implants: Experiences Of A Musician And Sound Engineer, René Vergè is a…
Enjoying Music With Cochlear Implants: Experiences Of A Musician And Sound Engineer, René Vergè is a musician and sound engineer from Germany – and he is also a bilateral recipient of MED-EL cochlear implants. He told us about his hearing journey and why, thanks to his cochlear implants, he could continue his work as a sound engineer. People repeatedly ask me whether it is possible to […] Read More

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Medicine by Alexandros G. Sfakianakis

07:10

Allergy and Immunology
Sat Jun 24, 2017 21:43 MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell lineupdated on Sun Jun 25, 2017 02:14 by Alexandros G. Sfakianakis via Allergy Rhinology Immunology AsthmaS01615890.gifPublication date: October 2017Source:Molecular Immunology, Volume 90Author(s): Man Luo, Lijuan Hu, Dandan Li, Yanying Wang, Yuting He, Lei Zhu, Weiying RenMyeloid differentiation protein 2 (MD-2) is required in the…

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Medicine by Alexandros G. Sfakianakis

Wed Jul 17, 2019 10:07

Plastic, Reconstructive & Aesthetic Surgery
Thu Jun 22, 2017 04:35 Comment on JPRAS-D-17-00333"Ex-Vivo Flush Of The Vascularised Limb Allograft Reduces Inflammatory Burden Prior To Transplantation"by Alexandros G. Sfakianakis via AestheticAlthough vascularised composite allotransplantation (VCA) is increasingly being performed and for a widening range of indications – some now consider transplantation to be the standard of care for mid-forearm amputations1 – more widespread application is limited by the risks associated with lifelong immunosuppression.http://ift.tt/2sCHPV6Add...

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Medicine by Alexandros G. Sfakianakis

Wed Jul 17, 2019 10:02

Biomechanics and Modeling in Mechanobiology
Correction to: Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experimentsIn the original publication of the article, Fig. 3 and Tables 2, 4 and 5 were published with errors. The issue was caused by an error in the code used to predict femoral strength in the finite element (FE) models.A data-driven model to study utero-ovarian blood flow physiology during pregnancyAbstractIn this paper, we describe a mathematical model of the cardiovascular…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:30

Osteoporosis
CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic PotentialAbstractPurpose of ReviewAge and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious,…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:29

Computer Assisted Radiology and Surgery
A markerless automatic deformable registration framework for augmented reality navigation of laparoscopy partial nephrectomyAbstractPurpose Video see-through augmented reality (VST-AR) navigation for laparoscopic partial nephrectomy (LPN) can enhance intraoperative perception of surgeons by visualizing surgical targets and critical structures of the kidney tissue. Image registration is the main challenge in the procedure. Existing registration methods in laparoscopic navigation systems suffer from…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:28

Toxicology
In vivo evaluation of the effect of arsenite on the intestinal epithelium and associated microbiota in miceAbstractChronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of this metalloid. The aim of this study is to perform an in vivo evaluation…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:27

Folia Microbiologica
An overview of 25 years of research on Thermococcus kodakarensis , a genetically versatile model organism for archaeal researchAbstractAlmost 25 years have passed since the discovery of a planktonic, heterotrophic, hyperthermophilic archaeon named Thermococcus kodakarensis KOD1, previously known as Pyrococcus sp. KOD1, by Imanaka and coworkers. T. kodakarensis is one of the most studied archaeon in terms of metabolic pathways, available genomic resources, established genetic engineering techniques,…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:26

Cancer and Metastasis Reviews
PrefaceCorrection to: mTOR co-targeting strategies for head and neck cancer therapyThe author’s name was tagged incorrectly in XML. “Silvio Gutkind J” should be tagged as “J. Silvio Gutkind”. Given name is “J. Silvio” and the Family name is “Gutkind”.Biography—Robert J. GilliesCorrection to: Tumor pH and metastasis: a malignant process beyond hypoxiaThe authors have noticed a typographical error in the published article. The term “epithelial-to-mesenchymal transition” should have been used instead…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:25

Hematology
Eltrombopag combined with cyclosporine may have an effect on very severe aplastic anemiaSuccessful management of transcatheter aortic valve implantation by platelet transfusions in a nonagenarian patient with severe autoimmune factor V deficiencyCirculating cell-free DNA for response evaluation of intravascular lymphomaClinicohematologic and cytogenetic profile in a rare case of pure erythroid leukemiaIntravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:24

Heat and Mass Transfer
Proposing a method for combining monitored multilayered perceptron (MLP) and self-organizing map (SOM) neural networks in prediction of heat transfer parameters in a double pipe heat exchanger with nanofluidAbstractThe purpose of this study was to investigate the efficiency of using magnesium oxide nanoparticles, twisted tapes with different and modified twist ratios, and the different rotation velocity of perforated twisted tapes in the evaluation of Nusselt number, overall heat transfer coefficient…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:24

Anesthesia & Analgesia
Factors Associated With Failure of Spinal Anesthetic: An 8-Year Retrospective Analysis of Patients Undergoing Elective Hip and Knee Joint ArthroplastyThe primary outcome of this 8-year retrospective review was the failure of spinal anesthetic (SA) in elective hip and knee joint arthroplasty surgery. Of 3542 SAs, a total of 135 failures were identified (3.8%). Factors associated with increased odds of failure were younger age (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.01–1.05), lower…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:19

Antonie van Leeuwenhoek
Mesorhizobium carboni s sp. nov., isolated from coal bed waterAbstractA Gram-stain negative, aerobic, motile, short rod-shaped bacterium, designated as B2.3T, was isolated from coal bed water collected from Jincheng, Shanxi Province, China. The strain was able to grow at 10–40 °C (optimum 28–30 °C), pH 4.0–10.0 (optimum 7.0), and in the presence of 0–5.0% NaCl (optimum 3.0%, w/v). Phylogenetic analysis based on the 16S rRNA and concatenated housekeeping gene recA, atpD and glnA sequences showed strain…

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:18

Anesthesia
Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesiaThere was an isolated error relating to the Oh et al. study (1) within our recurrence-free survival analysis. When the reported estimates for Oh et al. are corrected, the pooled hazard ratio (HR) is now 0.87; 95% confidence interval (CI), 0.66 to 1.15; P=0.32.Embolization of percutaneous closure deviceThe Pediatric Procedural Sedation HandbookWhat do non-critical care residents…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:17

Cognitive Neurodynamics
U1 snRNA over-expression affects neural oscillations and short-term memory deficits in miceAbstractSmall nuclear RNAs (snRNAs) and other RNA spliceosomal components are involved in neurological and psychiatric disorders. U1 snRNA has recently been demonstrated to be altered in pathology in some neurodegenerative diseases, but whether it has a causative role is not clear. Here we have studied this by overexpressing U1 snRNA in mice and measured their hippocampal oscillatory patterns and brain functions….

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:16

New Trends and Technologies in Facial Plastic Surgery, An Issue of Facial Plastic Surgery Clinics…
New Trends and Technologies in Facial Plastic Surgery, An Issue of Facial Plastic Surgery Clinics of North America, EbookJD Bloom – 2019Tissue Engineered Soft Tissue Reconstruction Using Non-invasive Mechanical Preconditioning and a Shelf-ready Allograft Adipose MatrixG Giatsidis, J Succar, TD Waters, W Liu, P Rhodius… – Plastic and Reconstructive …, 2019Background: Adipose tissue defects leading to severefunctional (disability) and morphological (di.[PDF] Seguridad de los injertos de grasa autólogos…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:15

[PDF] Cardiovascular imaging system, KD Taylor, K Harlan, J Nye, R Splinter, J Keeler… – US Patent…
[PDF] Cardiovascular imaging system,KD Taylor, K Harlan, J Nye, R Splinter, J Keeler… – US Patent App. 16/297,685, 2019… A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in bodycavities or body tracts, eg by using catheters. A—HUMAN … Drug therapy,including nitrates, beta-blockers, and peripheral vasodilatator drugs to dilate …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:10

An apparatus and system for acquiring data from bones and joints, plan surgery and manufacture instruments…
An apparatus and system for acquiring data from bones and joints, plan surgery and manufacture instruments or implants,MAELD HAFEZ – US Patent App. 16/096,921, 2019… SCIENCE; HYGIENE; A61B—DIAGNOSIS; SURGERY; IDENTIFICATION;A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves; … or formonitoring patient compliance relating to mechanical, radiation or invasive …

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:10

[PDF] Optical biopsy applicators for treatment planning, monitoring, and image-guided therapy, Z Chen,…
[PDF] Optical biopsy applicators for treatment planning, monitoring, and image-guided therapy,Z Chen, Y Miao, Y Li, BJ Tromberg, Y Tadir – US Patent App. 16/235,426, 2019… device; A61B8/4444—Constructional features of the ultrasonic, sonic orinfrasonic diagnostic device … Fractioned laser and other energy basedtherapies of atrophic vaginal mucosa leads to … Moreover, the duration of tissue …

sfakianakis19.blogspot.com?w=16&cs=3039609074&v=3

Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:10

Devices and techniques for cutting and coagulating tissue, JD Messerly, ET Wiener, BT Noyes, JL Aldridge… -…
Devices and techniques for cutting and coagulating tissue,JD Messerly, ET Wiener, BT Noyes, JL Aldridge… – US Patent App. 10/335,614, 2019Various embodiments are directed to a method of driving an end effectorcoupled to an ultrasonic drive system of a surgical instrument. The methodcomprises generating at least one electrical signal. The at least one electrical …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:10

Pulmonary Vasculitis, F Martínez – Chest Imaging, 2019 … What Not to Miss ■ The aortic wall thickness…
Pulmonary Vasculitis,F Martínez – Chest Imaging, 2019… What Not to Miss ■ The aortic wall thickness and the caliber of the headand neck vessel origins must always be evaluated on contrast-enhancedchest … Imaging Findings TAK ■ Early stage: Contrast-enhanced CT shows …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:09

[HTML] Immune-Related Adverse Events: A Case-Based Approach, C Connolly, K Bambhania, J Naidoo – Frontiers…
[HTML] Immune-Related Adverse Events: A Case-Based Approach,C Connolly, K Bambhania, J Naidoo – Frontiers in Oncology, 2019… Hodgkin lymphoma Hepatocellular carcinoma Melanoma Microsatelliteinstability-high (MSI-H) or mismatch-repair deficient (dMMR) CRC Non-smallcell lung cancer Renal cell carcinoma Small cell lung cancer Squamous …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:08

A pictorial approach to abdominal radiography, A Parry, P Mahoney – In Practice, 2019 … He is the vice-president…
A pictorial approach to abdominal radiography,A Parry, P Mahoney – In Practice, 2019… He is the vice-president of the European College of Veterinary Diagnostic Imaging (ECVDI)and head of radiology at Willows Referral Service … Good serosal detail requires thepresence of intra-abdominal white fat to provide contrast with soft tissue structures …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:08

[HTML] Safety and Tolerability of Targeted Medical Nutrition for Cachexia in Non-Small-Cell Lung Cancer:…
[HTML] Safety and Tolerability of Targeted Medical Nutrition for Cachexia in Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Controlled Pilot TrialA Laviano, PC Calder, AMWJ Schols, F Lonnqvist… – Nutrition and cancer, 2019… In patients with cancer, cachexia is defined as “a multifactorial syndromecharacterized by an ongoing loss of skeletal muscle mass (with or withoutloss of fat mass) that cannot be fully reversed by conventional nutritional …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:08

[ΒΙΒΛΙΟ] Cerebral Stroke, S Thaakur – 2019 – books.google.com, 1. INTROCUTION Stroke is defined as an…
[ΒΙΒΛΙΟ] Cerebral Stroke,S Thaakur – 2019 – books.google.com,1. INTROCUTION Stroke is defined as an abrupt and devastating illness. It is deliberated as aleading cause of adult disability (Adamson et al., 2004). Approximately 15 million people worldwidesuffer from stroke each year (Mackay and Mensah, 2004). It is recognized as fourth largest cause

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:07

Lung Cancer: Lymphadenopathy and Extrapulmonary Involvement, REC Benson – Chest Imaging, 2019 … Metastases Head■…
Lung Cancer: Lymphadenopathy and Extrapulmonary Involvement,REC Benson – Chest Imaging, 2019… Metastases Head■ and neck cancers, genitourinary … Direct chest wall invasion (Fig 48.6) ■Loss of extrapleural fat ■ Rib erosion/invasion and/or pathologic fracture Intercostalmuscle involvement ■ Pancoast tumor: Apical tumor with local invasion of adjacent ribs …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:07

[PDF] Approach to Patients with Neurotrauma and Thoracic Trauma and Anesthesia Management with Current…
[PDF] Approach to Patients with Neurotrauma and Thoracic Trauma and Anesthesia Management with Current Guidelines-1T Mıngır, C Kılınç, S Türkmen, M Erdal, A Aksu, İ Avcı… – 2019… contusion, aspiration of gastric contents, pneumonia, inhalation injury anddrowning, and severe traumatic shock, head trauma, abdominal sepsis,burns, fat embolism, excessive volume … The mediastinal emphysema will …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:06

Recognition and management of dermatologic complications from interventional radiology procedures M…
Recognition and management of dermatologic complications from interventional radiology proceduresM Ramirez, S Ravichandran, L Ronald… – … and Interventional Imaging, 2019… However, if biopsied, pathology will show dermal sclerosis with fat necrosisand foreign body … pruritic erythematous dermatitis 1 day after central venousport placement, extending up the neck … months after the procedure he …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:06

Tailored posterior pharyngeal fat grafting outcomes in velopharyngeal insufficiency managed according…
Tailored posterior pharyngeal fat grafting outcomes in velopharyngeal insufficiency managed according to a simplified algorithmR Denadai, CA Raposo-Amaral, A Sabbag, PR Vieira… – Annals of plastic surgery, 2019Background This study aimed to evaluate the outcomesof posterior pharyngeal fat grafting for the.

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:06

[PDF] COMPARATIVE STUDY OF HARMONIC SCALPEL VERSUS MONOPOLAR COAGULATION AND TITANIUM CLIPS IN LAPAROSCOPIC…
[PDF] COMPARATIVE STUDY OF HARMONIC SCALPEL VERSUS MONOPOLAR COAGULATION AND TITANIUM CLIPS IN LAPAROSCOPIC CHOLECYSTECTOMYAK Singh – International Journal of Scientific Research, 2019… The assessment were done under the following heads : Intra-operativeassessment – (a) Mean Operative time (b … supine with arms tucked to the sidewith right side up and head end up … gallbladder-cystic duct junction and CBD …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 11:06

Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation…
Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation of Prevotella corporisF Ciodaro, F Gazia, B Galletti, F Galletti – BMJ Case Reports CP, 2019Skip to main content. We use cookies to improve our service and to tailor our content andadvertising to you. More info You can manage your cookie settings via your browser atany time. To learn more about how we use cookies, please see our cookies policy …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:50

[HTML] Evidence-based prophylaxis strategies for postoperative nausea and vomiting when considering…
[HTML] Evidence-based prophylaxis strategies for postoperative nausea and vomiting when considering ethnicity factor,FY Su, WT Hung, LK Chen – Taiwanese Journal of Obstetrics and Gynecology, 2019… 2. Reduce Baseline Risk Factors for PONV; Guideline 3. Administer PONVProphylaxis Using 1 to 2 Interventions in Adults at Moderate Risk for PONV;and Guideline 4. Administer Prophylactic Therapy with Combination (≥2) …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:50

[PDF] Adenovirus and immunomodulator combination therapy F Tufaro, J FUEYO-MARGARETO, C Gomez-Manzano… -…
[PDF] Adenovirus and immunomodulator combination therapyF Tufaro, J FUEYO-MARGARETO, C Gomez-Manzano… – US Patent App. 16/304,359, 2019US20190201462A1 – Adenovirus and immunomodulator combination therapy – GooglePatents. Adenovirus and immunomodulator combination therapy. Download PDF Info.Publication number US20190201462A1. US20190201462A1 …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:50

Pediatric primary spinal atypical teratoid rhabdoid tumor: a case series and review of the literature …
Pediatric primary spinal atypical teratoid rhabdoid tumor: a case series and review of the literature D Li, DM Heiferman, HR Syed, JG Santos, RM Bowman… – Journal of Neurosurgery …, 2019… Atypical teratoid rhabdoid tumors (ATRTs) are rare malignant central nervous systemtumors, commonly occurring before 3 years of age. Median overall survival (OS) of patientswith these tumors is about 1 year, despite aggressive multimodal therapy …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:50

[HTML] Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids–the state…
[HTML] Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids–the state of art IP Ribeiro, JB de Melo, IM Carreira – Molecular Cytogenetics, 2019… Head and neck cancer: searching for genomic and epigenetic biomarkersin body fluids – the state of art … or non-invasive method also called as liquidbiopsy for diagnostic and prognostic biomarkers detection, representing …

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:49

Four-year pain relief after coblation combined with active exercise for cervical discogenic pain: Case…
Four-year pain relief after coblation combined with active exercise for cervical discogenic pain: Case reportX Li, L Yang, J Ni, Y Zhang – Medicine, 2019Rationale: Coblation of intervertebral disc is an effectiveand safe minimally invasive technology.

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:49

A nomogram prediction model for recurrent laryngeal nerve lymph node metastasis in thoracic oesophageal…
A nomogram prediction model for recurrent laryngeal nerve lymph node metastasis in thoracic oesophageal squamous cell carcinoma Y Liu, ZQ Zou, J Xiao, M Zhang, L Yuan, XG Zhao – Journal of Thoracic Disease, 2019A nomogram prediction model for recurrent laryngeal nerve lymph nodemetastasis in thoracic oesophageal squamous cell carcinoma.

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:49

Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receiving curative hepatectomy-an…
Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receiving curative hepatectomy-an analysis of 1,182 patients in Hong KongMY Chan, WH She, WC Dai, SH Yin Tsang… – Translational …, 2019Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receivingcurative hepatectomy- an analysis of 1182 patients in Hong Kong.

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:48

Psychiatry
Violence against doctors in India – Safety versus serviceOm Prakash SinghIndian Journal of Psychiatry 2019 61(4):325-326Safety and efficacy of adjunctive transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: An open-label trialSatish Kumar, Nand Kumar, Rohit VermaIndian Journal of Psychiatry 2019 61(4):327-334Introduction: The current pharmacological and psychotherapeutic approaches have limited benefit in symptom management of obsessive-compulsive disorder…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:45

Clinical and Experimental Medicine
Neutrocyte-to-lymphocyte ratio predicts the presence of a replicative hepatitis C virus strand after therapy with direct-acting antiviralsAbstractResidual HCV-RNA can persist in liver tissue and peripheral blood mononuclear cells (PBMCs) long after antiviral therapy of chronic hepatitis C in patients repeatedly negative for viral RNA in serum. This occult infection associates with impaired immune response and the risk of lymphoproliferative disorders or progressive liver disease. There are currently…

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Medicine by Alexandros G. Sfakianakis

Tue Jul 16, 2019 10:44

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Dermatologic Surgery

Aesthetic Outcomes of Nasal Burow’s Grafts With Interdomal Sutures After Mohs Micrographic Surgery
BACKGROUND Post-Mohs reconstruction of distal nasal defects is challenging. Many repair options exist, each with advantages and disadvantages. Utilization of a Burow’s graft in combination with manipulation of the underlying nasal cartilages with interdomal sutures is an underreported yet effective repair option. OBJECTIVE To present the authors’ experience with Burow’s grafts facilitated by interdomal sutures for repair of nasal defects after Mohs micrographic surgery (MMS). MATERIALS AND METHODS Patients who underwent repair with Burow’s grafts and interdomal sutures from 2013 to 2017 at a single university were identified. Demographics, follow-up, and complications were recorded. Two independent, board-certified dermatologists evaluated photographs for cosmesis and alar symmetry. RESULTS Thirty-one patients were identified. A total of 5/31 patients (16.1%) experienced minor complications without permanent sequelae. A total of 4/31 (12.9%) patients underwent cosmetic revision. No incidences of pincushioning, nasal valve dysfunction, or graft necrosis occurred. Aesthetic ratings were good to excellent with mean visual analog score of 80.8. Alar symmetry was excellent. CONCLUSION A Burow’s full-thickness skin graft facilitated by an interdomal suture to maintain nasal tip orientation and projection is an elegant repair technique for distal nasal oncologic defects with good to excellent aesthetic outcomes. It should be considered in the armamentarium for repair of distal nasal defects after MMS. Address correspondence and reprint requests to: Michael W. Pelster, Advanced Dermatology, 2950 Cullen Pkwy, Suite 102, Pearland, TX 77584, or e-mail: michael.w.pelster The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Patient Expectations Influence Postoperative Facial Satisfaction Measured by the FACE-Q Skin Cancer Module: A Pilot Study
No abstract available
Primary Cutaneous Umbilical Melanoma: The Michigan Experience
BACKGROUND Primary cutaneous umbilical melanoma is rare. Thorough information regarding its characteristics and treatment, including use of sentinel lymph node biopsy (SLNB) staging, is difficult to obtain. The unique anatomy of the umbilicus adds to the complexity of diagnosing and treating melanoma at this site. OBJECTIVE To improve understanding of diagnosis and treatment of primary cutaneous umbilical melanoma through presenting 7 new cases and reviewing 39 cases in the literature. MATERIALS AND METHODS The University of Michigan melanoma database query and review of the literature regarding reported cases of primary umbilical melanoma. RESULTS In 7 new and 39 previously reported cases of primary cutaneous umbilical melanoma, we describe signs and symptoms, histopathologic features, differential diagnosis, relevant anatomical considerations, and definitive treatment including SLNB when applicable. CONCLUSION Our series, combined with a thorough literature review and compilation of findings, provides a better understanding and appreciation of melanoma in the unique anatomical site of the umbilicus, with a reminder to carefully examine the umbilicus during a full skin examination in patients at risk of melanoma. Primary umbilical melanoma presents and can be appropriately treated similarly to cutaneous melanoma in other sites, with attention to relevant anatomy. Address correspondence and reprint requests to: Kelly B. Cha, MD, PhD, University of Michigan Health System, 1910 A. Alfred Taubman Center, 1500 E. Medical Center Drive, Suite 5314, Ann Arbor, MI 48109, or e-mail: kellycha The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
How Patients Value Scar Length Versus Scar Appearance and the Effect of Income Level on Willingness to Pay: Results From a Multicenter Discrete Choice Experiment
No abstract available
Safety of Subcutaneous Infiltration of Carbon Dioxide (Carboxytherapy) for Abdominal Fat Reduction: A Pilot Study
No abstract available
Cutaneous Leiomyosarcoma: A SEER Database Analysis
BACKGROUND Cutaneous leiomyosarcoma is a rare dermal neoplasm usually arising from the pilar smooth muscle. It is considered a relatively indolent neoplasm, and there is debate whether designation as sarcoma is appropriate. Owing to some conflicting data in the literature, however, its behavior warrants further clarification. OBJECTIVE To determine the clinical behavior and demographic and pathologic characteristics of cutaneous leiomyosarcoma. MATERIALS AND METHODS The Surveillance, Epidemiology and End Results database was used to collect data on cutaneous leiomyosarcoma and 2 reference populations: cutaneous angiosarcoma (aggressive) and atypical fibroxanthoma (indolent). Demographic and oncologic characteristics were examined, and overall survivals (OS) and disease-specific survivals were compared. RESULTS Leiomyosarcoma and atypical fibroxanthoma displayed lower stage (localized: 69.7% and 66.8% respectively), smaller size (<3 cm: 90.5% and 72%), and lower rates of disease-specific mortality (2.9% and 7.8%) compared with angiosarcoma. Patients with leiomyosarcoma had a 5-year disease-specific survival rate of 98% and OS rate of 85%. CONCLUSION Cutaneous leiomyosarcoma shows outcomes similar to atypical fibroxanthoma. It is nearly always indolent and should be distinguished from more aggressive cutaneous and subcutaneous sarcomas. Clear communication of the biologic potential may be best achieved using alternate diagnostic terminology such as “atypical intradermal smooth-muscle neoplasm.” Address correspondence and reprint requests to: Paul N. Bogner, MD, Departments of Pathology and Dermatology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, or e-mail: Paul.Bogner The authors have indicated no significant interest with commercial supporters. © 2019 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
Introducing the L-Lift—A Novel Approach to Treat Age-Related Facial Skin Ptosis Using A Collagen Stimulator
No abstract available
Commentary on Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large Lipoma
No abstract available
Time to Move on From Prescribing Oral Antibiotics as Prophylaxis for Mohs?
No abstract available
Outcomes for Basal Cell Carcinoma Treated With Vismodegib Extended Alternate Day Dosing
No abstract available

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Dermatologic Surgery

Bone & Joint Surgery

Publons: The Next Step in Reviewer Recognition
No abstract available
What’s New in Orthopaedic Trauma
No abstract available
Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty: An Analysis of 11,738 Cases
imageBackground: Povidone-iodine (PI) irrigation is often used prior to wound closure in total joint arthroplasty, but there are limited reports evaluating its efficacy in decreasing joint infections. The goal of this study was to compare the rate of any reoperation for infection (both superficial and deep) in primary total hip arthroplasty (THA) and primary total knee arthroplasty (TKA) among patients who did and did not receive PI irrigation prior to wound closure. Methods: Using our institution’s total joint registry, we identified 5,534 primary THA and 6,204 primary TKA procedures performed from 2013 to 2017. Cases were grouped on the basis of whether or not the wound was irrigated with 1 L of 0.25% PI prior to closure. PI irrigation was used in 1,322 (24%) of the THA cases and in 2,410 (39%) of the TKA cases. The rates of reoperation for infection at 3 months and 1 year were compared between the 2 groups. The same comparisons were then performed using propensity scores to account for differences in baseline characteristics. Results: The rate of reoperation for infection as assessed at 3 months following THA was similar between those who received dilute PI irrigation (0.9%) and who did not (0.7%) (p = 0.7). At 1 year, the rate of reoperation for infection was similar between those who received dilute PI irrigation (0.7%) and those who did not (0.9%) (p = 0.6). After using the propensity score, there was no difference between the groups in the risk of septic reoperations. For TKA, the rate of reoperation as assessed at 3 months was similar between those who received dilute PI irrigation (0.8%) and those who did not (0.3%) (p = 0.06). At 1 year, there was a greater rate of reoperations for infection among those who received dilute PI irrigation (1.2%) compared with those who did not (0.6%) (p = 0.03). However, there was no difference in the risk of septic reoperations between the groups after using the propensity score. Conclusions: Despite enthusiasm for and progressive adoption of the use of dilute PI irrigation at our institution, there was not a significant reduction in the risk of reoperation for infection as assessed at 3 months and 1 year following primary THA and TKA. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Povidone-Iodine Wound Lavage to Prevent Infection After Revision Total Hip and Knee Arthroplasty: An Analysis of 2,884 Cases
imageBackground: Postoperative infection remains a major challenge in revision total hip arthroplasty (THA) and revision total knee arthroplasty (TKA). Wound irrigation with dilute povidone-iodine (PI) solution has emerged as a simple, inexpensive, and potentially successful means of reducing postoperative infections. The aim of this study was to assess its effectiveness in reducing infection following revision THA and TKA in, to our knowledge, the largest revision cohort to date. Methods: Using our institution’s total joint registry, we identified 1,402 revision THAs and 1,482 revision TKAs performed during the study period (2013, when the PI irrigation protocol was first implemented, to 2017). The PI lavage protocol was employed in 27% of the revision THA cases and 34% of the revision TKA cases; in the remaining cases, the protocol was not used. Demographics, comorbid conditions, underlying surgical diagnoses, and whether the revision was for a septic or an aseptic etiology were compared between the groups (use or no use of PI irrigation). Any reoperation due to infection, as assessed at 3 and 12 months following revision arthroplasty, was compared between the groups and propensity scores were calculated to account for differences in baseline characteristics between the groups. Results: After adjusting for baseline differences between the groups using the propensity-score weighted models, we found no significant difference in the rate of reoperation for infection at 3 months (p = 0.58 for revision THA, and p = 0.06 for revision TKA) and at 12 months (p = 0.78 for revision THA, and p = 0.06 for revision TKA). Nonetheless, the hazard ratios from the propensity-score model trended higher for patients who received PI lavage: 1.6 and 1.3 for revision THA at 3 and 12 months, respectively, and 2.9 at both 3 and 12 months for revision TKA. Conclusions: PI wound lavage demonstrated no benefit in reducing any reoperation for infection following revision THA and TKA. Moreover, the trend toward higher rates for reoperation for infection among patients who received PI irrigation merit further consideration. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Association of Race and Ethnicity with Total Hip Arthroplasty Outcomes in a Universally Insured Population
imageBackground: Prior studies have documented racial and ethnic disparities in total hip arthroplasty (THA) outcomes in the U.S. The purpose of this study was to assess whether racial/ethnic disparities in THA outcomes persist in a universally insured population of patients enrolled in an integrated health-care system. Methods: A U.S. health-care system total joint replacement registry was used to identify patients who underwent elective primary THA between 2001 and 2016. Data on patient demographics, surgical procedures, implant characteristics, and outcomes were obtained from the registry. The outcomes analyzed were lifetime revision (all-cause, aseptic, and septic) and 90-day postoperative events (infection, venous thromboembolism, emergency department [ED] visits, readmission, and mortality). Racial/ethnic differences in outcomes were analyzed with use of multiple regression with adjustment for socioeconomic status and other potential confounders. Results: Of 72,755 patients in the study, 79.1% were white, 8.2% were black, 8.5% were Hispanic, and 4.2% were Asian. Compared with white patients, lifetime all-cause revision was lower for black (adjusted hazard ratio [HR], 0.79; 95% confidence interval [CI], 0.66 to 0.94; p = 0.007), Hispanic (adjusted HR, 0.73; 95% CI, 0.61 to 0.87; p = 0.002), and Asian (adjusted HR, 0.49; 95% CI, 0.37 to 0.66; p < 0.001) patients. Ninety-day ED visits were more common among black (adjusted odds ratio [OR], 1.15; 95% CI, 1.05 to 1.25; p = 0.002) and Hispanic patients (adjusted OR, 1.18; 95% CI, 1.08 to 1.28; p < 0.001). For all other postoperative events, minority patients had similar or lower rates compared with white patients. Conclusions: In contrast to prior research, we found that minority patients enrolled in a managed health-care system had rates of lifetime reoperation and 90-day postoperative events that were generally similar to or lower than those of white patients, findings that may be related to the equal access and/or standardized protocols associated with treatment in the managed care system. However, black and Hispanic patients still had higher rates of 90-day ED visits. Further research is required to determine the reasons for this finding and to identify interventions that could reduce unnecessary ED visits. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical Trial
imageBackground: Most patients undergoing surgery for the treatment of a distal radial fracture are treated in a day-surgery setting and are given either general anesthesia (GA) or regional anesthesia (RA). The main purpose of this study was to investigate the impact of the anesthesia method on patients’ postoperative opioid consumption during the first 3 days following surgery. Methods: This was a single-center randomized clinical trial. A total of 88 patients aged 18 to 74 years who were undergoing day surgery for the treatment of a displaced distal radial fracture with volar-plate fixation were randomized to GA (n = 44) or RA with a supraclavicular brachial plexus blockade (n = 44). The primary outcome was total opioid equivalent consumption (OEC) during the first 3 postoperative days (72 hours). Secondary outcomes included OEC during days 1, 2, and 3, visual analog scale (VAS) for pain scores, maximum pain, postoperative nausea and vomiting, perioperative time consumption (surgical, preoperative, and postoperative anesthesia care time), functional outcomes, and Patient-Rated Wrist Evaluation (PRWE) and EuroQol-5 Dimensions-3 Levels (EQ-5D-3L) scores up to 6 months. Results: The total median OEC during the first 3 postoperative days was 85 mg (range, 0 to 218 mg) in the GA group and 60 mg (range, 3 to 150 mg) in the RA group (p = 0.1). The groups differed significantly in OEC and VAS for pain scores during the first 24 hours after surgery; the median OEC was higher in the GA group before discharge (p < 0.001), while it was higher in the RA group after discharge (p < 0.001). Patients in the GA group reported more pain immediately after surgery (median score, 6; width of interquartile range [IQR], 7) and at 2 hours postoperatively (median score, 2; width of IQR, 3) compared with patients in the RA group (median score, 0; width of IQR, 0 at both time points) (p < 0.001). Maximum pain occurred at a median of 1 hour (range, 1 hour to 22 hours) after the end of surgery in the GA group compared with a median of 11 hours (range, 1 hour to 24 hours) in the RA group (p < 0.001). The total median perioperative time consumption was 244 minutes (range, 114 to 389 minutes) in the GA group compared with 146 minutes (range, 74 to 390 minutes) in the RA group (p < 0.001). There were no significant differences in functional outcomes or PRWE or EQ-5D-3L scores at 6 months. Conclusions: The anesthesia method (GA vs. RA) significantly influenced the early patterns of postoperative pain and opioid consumption after surgical treatment of a distal radial fracture, but neither total OEC over the first 3 postoperative days nor longer-term outcomes differed between the groups. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Step Activity After Surgical Treatment of Ankle Arthritis
imageBackground: Ambulatory activity is reduced in patients with ankle arthritis. In this study, we measured step activity over time in 2 treatment groups and secondarily compared step activity with results of patient-reported outcome measures (PROMs). Methods: Patients who were treated with either ankle arthrodesis or ankle arthroplasty wore a step activity monitor preoperatively and at 6, 12, 24, and 36 months postoperatively. Changes from preoperative baseline in total steps per day and per-day metrics of low, medium, and high-activity step counts were measured in both treatment groups. Step activity was compared with each subject’s PROM scores as reported on the Musculoskeletal Function Assessment (MFA) and the Short Form-36 (SF-36) physical function and bodily pain subscales. Results: Of the 3 activity levels, combined group high-activity step counts showed the greatest increase (mean of 278 steps [95% confidence interval (CI), 150 to 407 steps], a 46% improvement from preoperatively). At 6 months, the mean high-activity step improvement for the arthroplasty group was 194 steps compared with a mean decline of 44 steps for the arthrodesis group (mean 238-step difference [95% CI, −60 to 536 steps]). By 36 months postoperatively, the greater improvement in high-activity steps for the arthroplasty versus the arthrodesis group was no longer present. There were no significant pairwise differences in improvement based on surgical treatment method at any individual follow-up time point. For a within-patient increase of 1,000 total steps, there was a mean change in the MFA, SF-36 physical function, and SF-36 bodily pain scores of −1.8 (95% CI, −2.4 to −1.2), 3.8 (95% CI, 2.8 to 4.8), and 2.8 (95% CI, 1.8 to 3.9), respectively (p < 0.0001 for all associations). There was no evidence that the association differed by study visit, or by study visit and surgical procedure interaction (p > 0.10). Conclusions: Surgical treatment of ankle arthritis significantly improves ambulatory activity, with greater change occurring at high activity levels. Improvement may occur more quickly following arthroplasty than arthrodesis, but at 3 years, we detected no significant difference between the 2 procedures. Step counts, while associated with PROMs, do not parallel them, and thus may be a useful supplementary measure, particularly in longitudinal studies. Level of Evidence: Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Cemented Versus Cementless Total Knee Arthroplasty of the Same Modern Design: A Prospective, Randomized Trial
imageBackground: Highly porous surfaces promoting biologic fixation have renewed interest in cementless total knee arthroplasty (TKA), but the potential for failed biologic fixation remains. The purpose of this study was to compare the clinical outcomes of cemented and cementless versions of the same TKA design at an average of 2 years postoperatively. Methods: This was an institutional review board-approved, prospective, randomized controlled trial of patients from 18 to 75 years of age who were undergoing a primary TKA. Patients with inflammatory arthritis, a body mass index (BMI) of >40 kg/m2, infection, a neuromuscular disorder, or grossly osteoporotic bone or bone defects were excluded. Patients were randomized to receive a cemented or cementless cruciate-retaining TKA of the same design. The cementless implant has highly porous fixation surfaces. Oxford Knee, Knee Society, and Forgotten Joint Scores were collected. Patients were asked to rate the knee with the TKA as a percentage of normal. Power analysis indicated that 130 patients were necessary to demonstrate a 5-point difference in the Oxford Knee Score at 90% power. Results: One hundred and forty-seven patients were enrolled, and 141 (96%) of them were analyzed at an average of 2 years postoperatively. There was no difference in age, sex, BMI, American Society of Anesthesiologists (ASA) score, or duration of follow-up (p = 0.1 to 0.9). There was also no difference in the change in the hemoglobin level from the preoperative measurement to postoperative day 1 between the 2 cohorts (mean and standard deviation, −2.6 ± 1.4 g/dL compared with −2.5 ± 0.9 g/dL, p = 0.5), but the total operative time was decreased in the cementless cohort (82.1 ± 16.6 compared with 93.7 ± 16.7 minutes, p = 0.001). There were no differences in any clinical outcome measure at 4 to 6 weeks, 1 year, or an average of 2 years postoperatively (p = 0.1 to 0.9) between the cemented and cementless cohorts. There was no radiographic evidence of component subsidence or loosening in either cohort. Conclusions: This study demonstrated that a recently introduced cementless TKA had results, both perioperatively and at an average of 2 years postoperatively, that were equivalent to those of its cemented predecessor, without any aseptic failures of either implant. Thus, this study justifies continued surveillance of this device to elucidate both its survivorship and if it can provide any long-term benefits. Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Virtual Mechanical Testing Based on Low-Dose Computed Tomography Scans for Tibial Fracture: A Pilot Study of Prediction of Time to Union and Comparison with Subjective Outcomes Scoring
imageBackground: Quantitative outcomes assessment remains a persistent challenge in orthopaedic trauma. Although patient-reported outcome measures (PROMs) and radiographic assessments such as Radiographic Union Scale for Tibial Fractures (RUST) scores are frequently used, very little evidence has been presented to support their validity for measuring structural bone formation or biomechanical integrity. Methods: In this pilot study, a sequential cohort of patients with a tibial shaft fracture were prospectively recruited for observation following standard reamed intramedullary nailing in a level-I trauma center. Follow-up at 6, 12, 18, and 24 weeks included radiographs and completion of PROMs (EuroQol 5-Dimension [EQ-5D] and pain scores). Low-dose computed tomography (CT) scans were also performed at 12 weeks. Scans were reconstructed in 3 dimensions (3D) and subjected to virtual mechanical testing via the finite element method to assess torsional rigidity in the fractured limb relative to that in the intact bone. Results: Patients reported progressive longitudinal improvement in mobility, self-care, activity, and health over time, but the PROMs were not correlated with structural bone healing. RUST scoring showed moderate intrarater agreement (intraclass coefficient [ICC] = 0.727), but the scores at 12 weeks were not correlated with the time to union (R2 = 0.104, p = 0.193) and were only moderately correlated with callus structural integrity (R2 = 0.347, p = 0.010). In contrast, patient-specific virtual torsional rigidity (VTR) was significantly correlated with the time to union (R2 = 0.383, p = 0.005) and clearly differentiated 1 case of delayed union (VTR = 10%, union at 36 weeks) from the cases in the normally healing cohort (VTR > 60%; median union time, 19 weeks) on the basis of CT data alone. Conclusions: PROMs provide insight into the natural history of the patient experience after tibial fracture but have limited utility as a measure of structural bone healing. RUST scoring, although reproducible, may not reliably predict time to union. In contrast, virtual mechanical testing with low-dose CT scans provides a quantitative and objective structural callus assessment that reliably predicts time to union and may enable early diagnosis of compromised healing. Level of Evidence: Therapeutic Level IV. Please see Instructions for Authors for a complete description of levels of evidence.
The Effect of Coronal Alignment on Tibial Component Migration Following Total Knee Arthroplasty: A Cohort Study with Long-Term Radiostereometric Analysis Results
imageBackground: Recent short-term studies of total knee arthroplasty (TKA) have claimed improved clinical outcomes and implant survival when aiming to restore constitutional joint kinematics, as compared with neutral mechanical axis alignment. However, implant durability may be compromised when aligned in varus or valgus. With use of data pooled from 3 long-term radiostereometric analysis (RSA) studies, the aim of the present study was to assess the effects of coronal alignment on tibial component migration. Methods: Coronal alignment parameters from full-leg radiographs were measured and the constitutional leg alignment was determined for each patient. We evaluated the effect of the postoperative hip-knee-ankle angle, relative to both the mechanical axis and the constitutional alignment, on tibial component migration. In-range knees were defined as within ±3° of either the neutral mechanical axis or constitutional alignment of the patient. Analysis was performed with a linear mixed-effects model, corrected for study, age, sex, preoperative alignment, diagnosis, and body mass index. Results: A total of 85 cemented TKAs were included, of which 3 were revised for aseptic loosening and another 4 were considered loose. The median follow-up was 11 years. No loose tibial components were observed in mechanically in-range knees, whereas all loose tibial components were out of range. Mechanically varus knees showed the highest mean migration (maximum total point motion) of 1.55 mm (95% confidence interval [CI], 1.16 to 2.01 mm) after 5 years, compared with 1.07 mm (95% CI, 0.63 to 1.64 mm) and 0.77 mm (95% CI, 0.53 to 1.06 mm) for valgus and in-range knees, respectively (p < 0.001). In contrast, looking at constitutional alignment, loose tibial components were found among both constitutionally in-range and out-of-range knees. Mixed-model analysis showed comparable migration among constitutionally in-range, more-in-varus, and more-in-valgus aligned knees. Conclusions: Mechanically out-of-range alignment, especially mechanical varus, led to higher tibial component migration. However, matching the constitutional alignment of the patient did not preclude high implant migration. RSA trials randomizing different alignment techniques are needed to confirm the results of the present study. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Bone & Joint Surgery

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019) EditorialAccess to Quaternary Care:…
Ear, Nose & Throat Journal- Volume: 98, Number: 6 (July 2019)EditorialAccess to Quaternary Care: Studies Needed in OtolaryngologyRobert T. SataloffOtoscopic ClinicExophytic CholesteatomaMarcus L. Elias and Robert W. JyungRhinoscopic ClinicEndoscopic View of Fungus Ball in the Most Posterior Ethmoid Cell via the Supreme MeatusJae Hoon LeeLaryngoscopic ClinicsAn Unusual Hypopharyngeal Foreign Body Causing Dyspnea After VertebroplastySara Torretta, Alessandra Brevi, Claudio Guastella, Paolo Rampini, Marco…

Αλέξανδρος Γ. Σφακιανάκης

1m


Microsurgery Early View Online Version of Record before inclusion in an issue Microsurgery global…
MicrosurgeryEarly ViewOnline Version of Record before inclusion in an issueMicrosurgery global outreach to the developing world: Insights from VietnamAlbert H. Chao MDVersion of Record online: 12 July 2019Use of the subscapular system by maintaining unilateral decubitus placement without repositioning in microvascular free tissue transplantationAntonio J. Forte MD, PhD, Jeremie D. Oliver BS, BA, Matthew McRae MD, Cesar Colasante MD, Annica C. Eells BS, Andrew Watt MD, Rudolph Buntic MD, Gregory Buncke…

Αλέξανδρος Γ. Σφακιανάκης

1m

Documenta Ophthalmologica
Correlation between electroretinography, foveal anatomy and visual acuity in albinismAbstractBackgroundAlbinism patients have poor visual acuity in addition to hypopigmentation. Their foveal anatomy is abnormal, but correlation with function is incompletely understood. This study correlates retinal electrophysiology, visual acuity and optical coherence tomography (OCT) anatomy in albinism patients and compares with age-similar controls.MethodsInstitutional Review Board approval was obtained (IRB#…

Αλέξανδρος Γ. Σφακιανάκης

3m


Arteriovenous fistula presented with right ventricular failure, Farveh Vakilan, Fereshte Ghaderi,…
Arteriovenous fistula presented with right ventricular failure,Farveh Vakilan, Fereshte Ghaderi, Hoorak Poorzand, Mahmood Mohammadzadeh Shabestari, Arash GholobiArchives of Cardiovascular Imaging 2017 5(2):37-40Arteriovenous fistula could be traumatic with one manifestation as high-output heart failure. We present a 29-year-old male, referred for unexplained right-sided enlargement and the symptoms of right ventricular failure for 8 months ago. Considering right-sided dilatation, marked inferior…

Αλέξανδρος Γ. Σφακιανάκης

4m


Pregnancy complicated with severe aortic coarctation, Maryam Moshkani Farahani, Zahra Pour Jafar…
Pregnancy complicated with severe aortic coarctation,Maryam Moshkani Farahani, Zahra Pour JafarArchives of Cardiovascular Imaging 2017 5(2):35-36Coarctation of the aorta (COA) is a congenital disease with significant stenosis of the aorta which is associated with some complications such as hypertension. A 37-year-old pregnant woman was referred to our Cardiology Department for control of hypertension. She was in the 26th week of her gestation and she had another uneventful pregnancy 4 years ago….

Αλέξανδρος Γ. Σφακιανάκης

5m


Isolated congenital left ventricular diverticula: A rare cardiac anomaly, Nahid Rezaeian, Homa Najafi…
Isolated congenital left ventricular diverticula: A rare cardiac anomaly,Nahid Rezaeian, Homa NajafiArchives of Cardiovascular Imaging 2017 5(2):32-34Ventricular diverticula are a rare congenital abnormality characterized by synchronized contractility. Isolated diverticula mostly remain asymptomatic until adulthood. In this case report, we describe a 22-year-old woman with a history of pain in her arms and cold-induced skin discoloration. She was evaluated with echocardiography and cardiac magnetic…

Αλέξανδρος Γ. Σφακιανάκης

7m


Cardiac metastasis from a renal cell carcinoma without contiguous vena caval involvement, Azin Alizadeasl,…
Cardiac metastasis from a renal cell carcinoma without contiguous vena caval involvement,Azin Alizadeasl, Feridoun Noohi, Farnoosh Larti, Saeid Hosseini, Majid MalekiArchives of Cardiovascular Imaging 2017 5(2):30-31Tumors that involve the heart are more likely to represent metastatic disease than do primary cardiac neoplasms. Cardiac metastases from a renal cell carcinoma are rare and would be unique when there is no contiguous vena caval involvement such as the case that will be described here. Introduction Renal…

Αλέξανδρος Γ. Σφακιανάκης

7m

Cardiovascular Imaging
Left ventricular ejection fraction and mitral regurgitation assessment: A comparison study between echocardiography and angiographyAhmad Mirdamadi, Negah Tavakolifard, Ehsan EbrahimiArchives of Cardiovascular Imaging 2017 5(2):25-29Introduction: Measurement of the left ventricular ejection fraction (LVEF) is a common tool for evaluating the left ventricle (LV) systolic function. The aim of this study was to evaluate and compare the LVEF and mitral regurgitation (MR) severity as estimated by angiography…

Αλέξανδρος Γ. Σφακιανάκης

8m

Exercise Intensity Matters in Chronic Nonspecific Low Back Pain Rehabilitation, Introduction Exercise…
Exercise Intensity Matters in Chronic Nonspecific Low Back Pain Rehabilitation,Introduction Exercise therapy (ET) is advocated as a treatment for chronic nonspecific low back pain (CNSLBP). However, therapy effect sizes remain low. In other chronic disorders, training at higher intensity has resulted in greater improvements on both general health related and disease specific outcomes compared to lower intensity ET. Possibly, high intensity training also improves effect sizes in CNSLBP. Objective…

Αλέξανδρος Γ. Σφακιανάκης

9m

Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors, Purpose High-intensity…
Feasibility of Two High-Intensity Interval Training Protocols in Cancer Survivors,Purpose High-intensity interval training (HIIT) is a time-efficient and promising tool for enhancing physical fitness. However, there is lack of research concerning safety and feasibility of HIIT in cancer survivors. Therefore, two different HIIT protocols were investigated in terms of safety, feasibility, and acute exercise responses. Methods Forty cancer survivors (20 breast and 20 prostate cancer survivors, 62.9±9.2…

Αλέξανδρος Γ. Σφακιανάκης

9m

Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods, Purpose To…
Risk Estimates for Diabetes and Hypertension with Different Physical Activity Methods,Purpose To estimate risks of incident Type 2 Diabetes (T2D) and Stage 2 and greater hypertension associated with self-reported and accelerometer-determined moderate-vigorous physical activity (MVPA) separately and adjusted for each other. Methods The sample included 2,291 black and white men and women, ages 38-50, in the CARDIA (Coronary Artery Risk Development in Young Adults) Fitness Study, conducted during the…

Αλέξανδρος Γ. Σφακιανάκης

10m

Medicine & Science in Sports & Exercise
Resistance Exercise-induced Changes in Muscle Metabolism are Load-dependentIntroduction Lower-load (LL), higher-repetition resistance exercise training (RET) can increase muscle mass similar degree as higher-load (HL), lower-repetition RET. However, little is known about how LL and HL RET modulate other aspects of the RET phenotype such as satellite cells, myonuclei, and mitochondrial proteins. We aimed to investigate changes in muscle mass, muscle strength, satellite cell activity, myonuclear addition,…

Αλέξανδρος Γ. Σφακιανάκης

10m


Journal of the European Academy of Dermatology and Venereology Accepted Articles Accepted, unedited…
Journal of the European Academy of Dermatology and VenereologyAccepted ArticlesAccepted, unedited articles published online and citable. The final edited and typeset Version of Record will appear in the future.Comparing Treatments for Basal Cell Carcinoma in Terms of Long‐term Treatment‐Failure: A Network Meta‐analysisTakeshi Fukumoto, Rie Fukumoto, Masahiro Oka, Nobuyuki HoritaFirst Published: 13 July 2019Incidence of cutaneous adverse events after exposure to tenofovir‐emtricitabine in HIV‐uninfected…

Αλέξανδρος Γ. Σφακιανάκης

11m


Journal of the European Academy of Dermatology and Venereology Early View Online Version of Record…
Journal of the European Academy of Dermatology and VenereologyEarly ViewOnline Version of Record before inclusion in an issue Open AccessComments on ‘French guidelines on the use of systemic treatments for moderate‐to‐severe psoriasis in adults’C. Schuster, E. Perrin, E. RiedlVersion of Record online: 11 July 2019Review of autoimmune blistering diseases: the Pemphigoid diseasesB.S. Daniel, D.F. MurrellVersion of Record online: 11 July 2019Incidence and prevalence of psoriasis in Israel between 2011…

Αλέξανδρος Γ. Σφακιανάκης

11m


Supervised monthly doses of rifampicin-ofloxacin-minocycline (ROM)………..Rifampicin to be swallowed in front of a health worker (best on an empty stomach or at least 2 h after a meal; a total of 6 doses [6 months]) Ofloxacin to be swallowed in clinic once monthly – 6 doses Minocycline to be swallowed in clinic once monthly – 6 doses Dapsone once daily for 6 months. This treatment is likely to work even if the patient fails to take the daily doses of dapsone. More than three skin patches (MB) or if the skin smear was positive (if there are more than three patches, give this treatment even if the skin smear was negative): Give the same treatment as mentioned above, but also give clofazimine monthly to be swallowed in the clinic and a daily clofazimine dose as in
Suggested protocol for the management of leprosy by primary health-care cliniciansRajkumar RamasamyKC Patty Primary Health Centre, Kodaikanal, Tamil Nadu, IndiaDate of Web Publication16-Jul-2019Correspondence Address:Dr. Rajkumar RamasamyKC Patty Primary Health Centre, Kodaikanal, Tamil Nadu,IndiaSource of Support: None, Conflict of Interest: None Abstract The new WHO guideline for the management of leprosy may not address all the grass roots realities of treating and preventing leprosy effectively…

Αλέξανδρος Γ. Σφακιανάκης

14m


Inferior vena cava filters – An overview, Sasank Kalipatnapu, Sunil Agarwal Department of Vascular…
Inferior vena cava filters – An overview,Sasank Kalipatnapu, Sunil AgarwalDepartment of Vascular Surgery, Christian Medical College, Vellore, Tamil Nadu, IndiaDate of Web Publication16-Jul-2019Correspondence Address:Dr. Sasank KalipatnapuDepartment of Vascular Surgery, Christian Medical College, Vellore – 632 002, Tamil NaduIndiaSource of Support: None, Conflict of Interest: None Abstract Inferior Vena Cava Filters have been proven to prevent pulmonary embolism in patients with deep venous thrombosis…

Αλέξανδρος Γ. Σφακιανάκης

17m


Indications and contraindications for inferior vena cava filters*, Table 1: Types of filters
Indications and contraindications for inferior vena cava filters*,Table 1: Types of filters

Αλέξανδρος Γ. Σφακιανάκης

18m


Drug Dialogues. Curr Med Issues [serial online] 2019 [cited 2019 Jul 17];17:18-9. Available from:
Drug Dialogues. Curr Med Issues [serial online] 2019 [cited 2019 Jul 17];17:18-9. Available from: http://www.cmijournal.org/text.asp?2019/17/1/18/262826

Αλέξανδρος Γ. Σφακιανάκης

19m

Medical Issues
Evaluation of discharge letters of patients who went against medical advice from the emergency department: A complete audit cycleKrishna Prasad, Linu SekharCurrent Medical Issues 2019 17(1):1-5Aim: The aim was to evaluate the discharge letters of patients who went “against medical advice” (AMA) from the emergency department (ED) before and after the introduction of a preformatted discharge letter in a tertiary care center in India. Methods: A prospective clinical audit of case sheets of 200 patients…

Αλέξανδρος Γ. Σφακιανάκης

20m

Morphometry of organization of middle meningeal artery through the analysis of bony canal in human’s…
Morphometry of organization of middle meningeal artery through the analysis of bony canal in human’s skull: A clinico-anatomical and embryological insightThittamaranahalli Muguregowda Honnegowda, Vineeth Dineshan, Ashwini KumarJournal of Craniovertebral Junction and Spine 2019 10(2):127-130Background: Middle meningeal artery (MMA) is the largest branch of the maxillary artery supplying meninges of the cranial cavity. The complexity of MMA development gives many opportunities for anatomical variation….

Αλέξανδρος Γ. Σφακιανάκης

21m

Posterior occiput-cervical fixation for metastasis to upper cervical spine Tarush Rustagi, Hazem Mashaly,…
Posterior occiput-cervical fixation for metastasis to upper cervical spineTarush Rustagi, Hazem Mashaly, Ehud MendelJournal of Craniovertebral Junction and Spine 2019 10(2):119-126Background: Metastasis to craniocervical area may result in instability manifesting as disabling pain, cranial nerve dysfunction, paralysis, or even death. Stabilization is required to prevent complications. Nonoperative treatment modalities are ineffective in providing stability and adequate pain relief. We present our…

Αλέξανδρος Γ. Σφακιανάκης

22m

Cervical rotation before and after hinge-door cervical laminoplasty for cervical spondylotic myelopathy…
Cervical rotation before and after hinge-door cervical laminoplasty for cervical spondylotic myelopathySachin A Borkar, Ravi Sreenivasan, Ravi Sharma, Sumit Sinha, S Leve Joseph, Ajay Garg, Shashank Sharad KaleJournal of Craniovertebral Junction and Spine 2019 10(2):114-118Background: Hinge-Door Cervical laminoplasty is commonly performed procedure in patients with cervical spondylotic myelopathy. Most available studies have established restriction of flexion and extension motion post laminoplasty…

Αλέξανδρος Γ. Σφακιανάκης

22m

Prevention of lumbar reherniation by the intraoperative use of a radiofrequency bipolar device: A case–control…
Prevention of lumbar reherniation by the intraoperative use of a radiofrequency bipolar device: A case–control studyGiovanni Grasso, Fabio Torregrossa, Alessandro LandiJournal of Craniovertebral Junction and Spine 2019 10(2):94-99Objective: The most common complication after lumbar discectomy is reherniation. Although many studies have investigated factors that may increase the reherniation risk, few are agreed upon all. It has been suggested that limited nucleus removal is associated with higher…

Αλέξανδρος Γ. Σφακιανάκης

22m

A limited unilateral transpedicular approach for anterior decompression of the thoracolumbar spinal…
A limited unilateral transpedicular approach for anterior decompression of the thoracolumbar spinal cord in elderly and high-risk patientsKhalid Alsaleh, Amjad AlduhaishJournal of Craniovertebral Junction and Spine 2019 10(2):88-93Background: Surgical treatment for elderly patients with thoracolumbar (TL) kyphosis and spinal cord (SC) compression presents significant challenges due to compression location, the amount of deformity, and patient’s medical status might not permit full correction of the…

Αλέξανδρος Γ. Σφακιανάκης

23m

Torticollis and rotatory atlantoaxial dislocation: A clinical review Atul Goel Journal of Craniovertebral…
Torticollis and rotatory atlantoaxial dislocation: A clinical reviewAtul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):77-87Rotatory atlantoaxial instability can manifest as an acute episode following subtle or minor injury or even following a gentle tap on head in young children and can manifest as a painless deformity of the head. Goel technique of direct surgical opening of the atlantoaxial facet joint, manual manipulation of the facets can lead to reduction of rotatory atlantoaxial…

Αλέξανδρος Γ. Σφακιανάκης

23m

Craniovertebral Junction and Spine
Is the term degenerative “spinal canal stenosis” a misnomer?Atul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):75-76Torticollis and rotatory atlantoaxial dislocation: A clinical reviewAtul GoelJournal of Craniovertebral Junction and Spine 2019 10(2):77-87Rotatory atlantoaxial instability can manifest as an acute episode following subtle or minor injury or even following a gentle tap on head in young children and can manifest as a painless deformity of the head. Goel technique of direct…

Αλέξανδρος Γ. Σφακιανάκης

23m

Tropical Biomedicine
Development of new lateral-flow immunochromatographic strip using colloidal gold and mesoporous silica nanoparticles for rapid diagnosis of active schistosomiasisManal Kamel, Faten Salah, Zeinab Demerdash, Sara Maher, Shimaa Atta, Abeer Badr, Ahmed Afifi, Hanan El BazAsian Pacific Journal of Tropical Biomedicine 2019 9(8):315-322Objective: To develop a new sandwich based lateral flow immunochromatographic strip for rapid detection of circulating Schistosoma mansoni antigen in serum and urine samples…

Αλέξανδρος Γ. Σφακιανάκης

24m

Medical Research
‘More, better, faster & sustained’: Strengthen primary health care to advance universal health coverageChandrakant LahariyaIndian Journal of Medical Research 2019 149(4):433-436Emerging evidence that irritable bowel syndrome & functional dyspepsia are microbial diseasesNicholas J Talley, Marjorie M WalkerIndian Journal of Medical Research 2019 149(4):437-440Young-onset diabetes: An Indian perspectiveDeep Dutta, Soumitra GhoshIndian Journal of Medical Research 2019 149(4):441-442Clinical epidemiology…

Αλέξανδρος Γ. Σφακιανάκης

25m

Nephrology
Healthcare in India and violence against doctors: The missing linksSanjay Kumar AgarwalIndian Journal of Nephrology 2019 29(4):221-231Reset osmostat: Facts and controversiesJ Feder, JM Gomez, F Serra-Aguirre, CG MussoIndian Journal of Nephrology 2019 29(4):232-234Reset osmostat (RO) consists of a change in the normal plasma osmolality threshold (reduction or increase), which consequently induces chronic dysnatremia (hyponatremia or hypernatremia). Although the early papers on RO state that hyponatremic…

Αλέξανδρος Γ. Σφακιανάκης

26m

Anesthesia-Analgesia
Antiphospholipid Syndrome During Septic Shock: Hyper- or Hypocoagulability?: A Case ReportWe report the clinical case of a septic patient with antiphospholipid syndrome who developed ischemia in all 4 limbs, despite a normal systemic blood pressure. Prolonged coagulation times suggested a hemorrhagic diathesis, requiring transfusion of fresh-frozen plasma and discontinuation of heparin infusion. In contrast, the study of the viscoelastic properties of the clot by thromboelastography suggested an…

Αλέξανδρος Γ. Σφακιανάκης

27m

Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic…
Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic rhinitisAuthor links open overlay panelYao-zuZhangJuanLuoZi-hanWangJieWangDepartment of Otolaryngology-Head and Neck Surgery, The Affiliated Children Hospital of Xi’an Jiao Tong University, Shanxi, Xi’an 710003, ChinaReceived 4 May 2019, Available online 16 July 2019.Show lesshttps://doi.org/10.1016/j.amjoto.2019.07.010Get rights and contentAbstractObjectiveTo explore the efficacy and safety of sublingual…

Αλέξανδρος Γ. Σφακιανάκης

28m


Mycoses Volume 62, Issue 8Pages: 617-709 August 2019 ISSUE INFORMATION Issue Information Pages: 617-619…
MycosesVolume 62, Issue 8Pages: 617-709August 2019ISSUE INFORMATIONIssue InformationPages: 617-619 | First Published: 15 July 2019REVIEW ARTICLESCandida auris—the growing menace to global healthShabir A. Lone, Aijaz AhmadPages: 620-637 | First Published: 17 February 2019Vaginal yeast colonisation: From a potential harmless condition to clinical implications and management approaches—A literature reviewPanagiota Chatzivasileiou, Timoleon‐Achilleas VyzantiadisPages: 638-650 | First Published: 30 April…

Αλέξανδρος Γ. Σφακιανάκης

28m


Skin Research and Technology
Skin Research and TechnologyVolume 25, Issue 4Pages: 413-591July 2019ISSUE INFORMATIONISSUE INFORMATIONPages: 413 | First Published: 15 July 2019ORIGINAL ARTICLESInstrumental and sensory methodologies to characterize the residual film of topical products applied to skinGéraldine Savary, Laura Gilbert, Michel Grisel, Céline PicardPages: 415-423 | First Published: 15 February 2019Noninvasive analysis of skin proteins in healthy Chinese subjects using an Orbitrap Fusion Tribrid mass spectrometerJie…

Αλέξανδρος Γ. Σφακιανάκης

29m

Skin Research and Technology
Improved skin lesion edge detection method using Ant Colony OptimizationSkin Research and Technology, EarlyView. Classification and influencing factors analysis of facial skin color in Chinese populationSkin Research and Technology, EarlyView. Development of a new diaper dermatitis‐like reconstructed skin equivalent for testing children atopic dermatitis relieving cosmeticsSkin Research and Technology, EarlyView. Reflectance confocal microscopy and histological features of depigmentation after local…

Αλέξανδρος Γ. Σφακιανάκης

30m

Kavita Sivaramakrishnan. As the World Ages: Rethinking a Demographic Crisis, Pat Thane Alan I. Marcus, Malignant…
Kavita Sivaramakrishnan. As the World Ages: Rethinking a Demographic Crisis, Pat Thane Alan I. Marcus, Malignant Growth: Creating the Modern Cancer Research Establishment, 1875-1915 Kirsten E Gardner

Αλέξανδρος Γ. Σφακιανάκης

31m

Molecular typing of Streptococcus agalactiae isolates of serotype Ia from tilapia in southern China, Youlu…
Molecular typing of Streptococcus agalactiae isolates of serotype Ia from tilapia in southern China, Youlu Su; Chan Liu; Yiqin Deng; Changhong Cheng; Hongling Ma …

Αλέξανδρος Γ. Σφακιανάκης

32m

Pre-existing anti-neuraminidase antibodies are associated with shortened duration of influenza A (H1N1)pdm…
Pre-existing anti-neuraminidase antibodies are associated with shortened duration of influenza A (H1N1)pdm virus shedding and illness in naturally infected adults Hannah E Maier ; Raffael Nachbagauer; Guillermina Kuan; Sophia Ng; Roger Lopez … National safety survey of animal-use commercial probiotics and its spillover effects from farm to human: an emerging threat to public health Songzhe Fu; Qian Yang; Fenglan He; Ruiting Lan; Jingwei Hao … Graded Dalbavancin Challenge in a Patient with…

Αλέξανδρος Γ. Σφακιανάκης

32m

The Expectations and Challenges of Wildlife Disease Research in the Era of Genomics: Forecasting with…
The Expectations and Challenges of Wildlife Disease Research in the Era of Genomics: Forecasting with a Horizon Scan-like Exercise Genomic signatures of selection along a climatic gradient in the northern range margin of the white-footed mouse (Peromyscus leucopus) A Garcia-Elfring; R D H Barrett; V Millien

Αλέξανδρος Γ. Σφακιανάκης

32m

Pituitary
AcroVoice: the controversial values in reflecting acromegaly disease activityCorrection to: Rathke’s cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysisThe original version of this article unfortunately contained errors in legend numbers of Figure 2 caption.Ectopic pituitary adenomas: common presentations of a rare entityAbstractPurposeEctopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal…

Αλέξανδρος Γ. Σφακιανάκης

33m

Rathke’s cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysis…
Rathke’s cleft cysts: a 6-year experience of surgery vs. observation with comparative volumetric analysisAbstractBackgroundRathke’s cleft cysts (RCCs) are common sellar lesions. Their management remains controversial, particularly when small or asymptomatic. Herein we review a consecutive series of RCC patients managed with surgery or observation.MethodsAll patients with a new diagnosis of presumed RCC, based on MRI, from February 2012–March 2018 were retrospectively divided into observational and…

Αλέξανδρος Γ. Σφακιανάκης

33m

Role of gamma knife radiosurgery in the treatment of prolactinomas AbstractPurpose Stereotactic radiosurgery…
Role of gamma knife radiosurgery in the treatment of prolactinomasAbstractPurposeStereotactic radiosurgery is one of the treatment options for prolactinomas, the most commonly used being Gamma Knife Radiosurgery (GKRS). GKRS is indicated mainly in the treatment of dopamine agonist (DA)-resistant prolactinomas. In our study, we report on our experience in treating prolactinoma patients by GKRS.MethodsTwenty-eight patients were followed-up after GKRS for 26–195 months (median 140 months). Prior to…

Αλέξανδρος Γ. Σφακιανάκης

34m

Preoperative visual evoked potential in the prediction of visual outcome after pituitary macroadenomas…
Preoperative visual evoked potential in the prediction of visual outcome after pituitary macroadenomas surgeryAbstractObjectiveThe purpose of the present study is to investigate longitudinal changes in Visual evoked potential (VEP) parameters as an objective test after transsphenoidal surgery, its correlation with subjective tests and clinical value of VEP in the prediction of visual outcome.MethodsFifty patients with pituitary macroadenoma who underwent surgical removal of the tumor recruited in…

Αλέξανδρος Γ. Σφακιανάκης

34m

Ectopic pituitary adenomas: common presentations of a rare entity AbstractPurpose Ectopic pituitary…
Ectopic pituitary adenomas: common presentations of a rare entityAbstractPurposeEctopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size.MethodsWe performed a single-center retrospective analysis of patients with diagnosis of ectopic pituitary adenoma from 2001 to 2018.ResultsFive patients were identified with EPA:…

Αλέξανδρος Γ. Σφακιανάκης

34m


Development and Preliminary Findings of the Dizziness Symptom Profile Ear & Hearing…
Development and Preliminary Findings of the Dizziness Symptom ProfileEar & Hearing OnlineOfficial Journal of the American Auditory SocietyThe Power of Partnerships: Audiologist-Physician Collaboration Improves Patient CareThe Hearing JournalTeaching Written Expression to Students With Autism Spectrum Disorder and Complex Communication NeedsTopics In Language Disorders

Αλέξανδρος Γ. Σφακιανάκης

35m

Risk Factors For Childhood And Adult Primary Brain Tumors, Quinn T Ostrom; Maral Adel Fahmideh; David…
Risk Factors For Childhood And Adult Primary Brain Tumors, Quinn T Ostrom; Maral Adel Fahmideh; David J Cote; Ivo S Muskens ; Jeremy Michals Schraw… CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas , Romain Appay; Caroline Dehais; Claude-Alain Maurage ; Agusti Alentorn; Catherine Carpentier

Αλέξανδρος Γ. Σφακιανάκης

36m

Verhandelte Stadt: Herrschaft und Gemeinde in der frühen Urbanisierung des Oberelsass vom 12. bis 14….
Verhandelte Stadt: Herrschaft und Gemeinde in der frühen Urbanisierung des Oberelsass vom 12. bis 14. Jahrhundert, Tom Scott

Αλέξανδρος Γ. Σφακιανάκης

36m

Les pratiques politiques dans les françaises d’Ancien Régime: Communauté, citoyenneté et localité, Robert…
Les pratiques politiques dans les françaises d’Ancien Régime: Communauté, citoyenneté et localité, Robert A Schneider The Return of Alsace to France, 1918–1939 Detmar Klein Fighting for France. Violence in Interwar French Politics Martin Simpson

Αλέξανδρος Γ. Σφακιανάκης

37m

A Microhistory of the Global Empire of Cotton: Ivanovo, the ‘Russian Manchester’, Alison K Smith 1989…
A Microhistory of the Global Empire of Cotton: Ivanovo, the ‘Russian Manchester’, Alison K Smith 1989 at Thirty: A Recast Legacy Paul Betts Rejecting Catastrophe: the case of the Justinianic Plague Lee Mordechai; Merle Eisenberg

Αλέξανδρος Γ. Σφακιανάκης

37m

Lasers in Medical Science
Correction to: Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell’s) palsyThe published version contains a mistake in Figure 1. Below is the correct figure.Methodological correctness of a recent publication on pain entitled “Evaluating the effect of photobiomodulation with a 940-nm diode laser on post-operative pain in periodontal flap surgery”Laser-assisted hatching and clinical outcomes in frozen-thawed cleavage-embryo transfers of patients…

Αλέξανδρος Γ. Σφακιανάκης

38m

Diagnostic value of surveillance 18 F-fluorodeoxyglucose PET/CT for detecting recurrent esophageal…
Diagnostic value of surveillance 18 F-fluorodeoxyglucose PET/CT for detecting recurrent esophageal carcinoma after curative treatmentAbstractPurposeEsophageal carcinoma recurs within two years in approximately half of patients who receive curative treatment and is associated with poor survival. While 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a reliable method of detecting recurrent esophageal carcinoma, in most previous studies FDG PET/CT scans were…

Αλέξανδρος Γ. Σφακιανάκης

38m

Metabolic tumor burden on baseline 18 F-FDG PET/CT improves risk stratification in pediatric patients…
Metabolic tumor burden on baseline 18 F-FDG PET/CT improves risk stratification in pediatric patients with mature B-cell lymphomaAbstractPurposeIn order to better identify patients most at risk of treatment failure and disease progression in pediatric mature B-cell non-Hodgkin lymphoma (B-NHL), the prognostic role of metabolic tumor burden measured on baseline 18F-FDG PET/CT scan, including total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), was investigated.MethodsPretreatment 18F-FDG…

Αλέξανδρος Γ. Σφακιανάκης

39m

Nuclear Medicine and Molecular Imaging
Eleanor Mantel, Janet S. Reddin, Gang Cheng, Abass Alavi (Eds): Nuclear Medicine Technology. Review Questions for the Board Examinations, Fifth Edition. Springer International Publishing AG, 2018. ISBN 978-3-319-62499-018 F-FDG PET/CT of sarcoidosis with extensive cutaneous and subcutaneous nodules: the snow leopard signAbdelhamid H Elgazzar, Ismet Sarikaya (Eds): Nuclear Medicine Companion. A Case-Based Practical Reference for Daily UseImaging of coronary flow capacity: is there a role for dynamic…

Αλέξανδρος Γ. Σφακιανάκης

39m


Cardiac Imaging Left Atrial Fibrosis Assessed with Cardiac MRI in Patients with Paroxysmal and…
Cardiac Imaging Left Atrial Fibrosis Assessed with Cardiac MRI in Patients with Paroxysmal and Those with Persistent Atrial Fibrillation Focal left atrial fibrosis localized to the left inferior pulmonary vein antrum, the extent of left atrial fibrosis, and enlarged left atrial volume were independently associated with persistent atrial fibrillation at cardiac MRI. Dong Kyu Lee, Jaemin Shim…Sung Ho Hwang Editorial: Searching for the Key to Foreseeing Left Atrial Fibrosis in Atrial Fibrillation:…

Αλέξανδρος Γ. Σφακιανάκης

40m

Biophysics
Biophysical characterization and molecular phylogeny of human KIN proteinAbstractThe DNA/RNA-binding KIN protein was discovered in 1989, and since then, it has been found to participate in several processes, e.g., as a transcription factor in bacteria, yeasts, and plants, in immunoglobulin isotype switching, and in the repair and resolution of double-strand breaks caused by ionizing radiation. However, the complete three-dimensional structure and biophysical properties of KIN remain important information…

Αλέξανδρος Γ. Σφακιανάκης

41m

Microbiology
RETRACTED ARTICLE: Phytobacter nematintestini sp. nov., isolated from the intestine of Caenorhabditis elegans and conferring resistance to Bacillus nematocida infectionThaumarchaeota affiliated with Soil Crenarchaeotic Group are prevalent in the alkaline soil of an alpine grassland in northwestern ChinaAbstractPurposeThaumarchaeota are key players within the global nitrogen cycle. Investigations of the Thaumarchaeota communities are important for an integrated understanding of nitrogen nutrient cycle…

Αλέξανδρος Γ. Σφακιανάκης

42m


Tα ομορφότερα μικρά νησιά του Αιγαίου Είναι μικρά, μοναχικά και πανέμορφα…
Tα ομορφότερα μικρά νησιά του Αιγαίου Είναι μικρά, μοναχικά και πανέμορφα…

Αλέξανδρος Γ. Σφακιανάκης

43m


Η Μήλος θυμίζει κάτι… από Σελήνη, Η Μήλος είναι το εξωτικό νησί του Αιγαίου με ηφαιστειογενή…
Η Μήλος θυμίζει κάτι… από Σελήνη,Η Μήλος είναι το εξωτικό νησί του Αιγαίου με ηφαιστειογενή πετρώματα, που χρωματίζουν τους βράχους των παραλίων ροζ, πορτοκαλί, κόκκινο και μαύρο.

Αλέξανδρος Γ. Σφακιανάκης

43m

Hematology
Familial case of hereditary Pelger-Huët anomalyDetection of Jordans’ anomaly using compact-type automated hematology analyzerMacrophage elimination in bone marrow by dexamethasone palmitate is associated with successful engraftment in patients with hemophagocytic syndromeEpigenetic abnormalities and therapies for hematological malignanciesThe current state of human immunodeficiency virus-associated lymphoma in Japan: a nationwide retrospective study of the Japanese Society of Hematology Blood Disease…

Αλέξανδρος Γ. Σφακιανάκης

43m


Journal of Cosmetic Dermatology Early View Online Version of Record before inclusion in an issue …
Journal of Cosmetic DermatologyEarly ViewOnline Version of Record before inclusion in an issue Open AccessIn vivo evaluation of the effectiveness of biocellulose facial masks as active delivery systems to skinPaola Perugini PhD, Mariella Bleve PhD, Renato Redondi PhD, Fabiola Cortinovis, Antonio Colpani PhDVersion of Record online: 13 July 2019Alopecia areata predictive score: A new trichoscopy‐based tool to predict treatment outcome in patients with patchy alopecia areataAnna Waśkiel‐Burnat MD,…

Αλέξανδρος Γ. Σφακιανάκης

44m

Pediatrics
Notice of Duplicate PublicationDetermination of Procalcitonin, C-Reactive Protein and White Blood Cell Levels to Diagnose Community-Acquired Pneumonia (CAP)Apple Peel Atresia with Isolated Fetal Ascites and Digit AnomaliesAssociation of Fecal Microflora with BronchiolitisRadCases Plus Q&A Pediatric Imaging: Richard B. Gunderman and Lisa R. Delaney (eds)Sialidosis Type 1: Giant SSEP and Novel MutationCarbon Monoxide Poisoning in a NeonateSerum Albumin and C-Reactive Protein as Predictors of Adverse…

Αλέξανδρος Γ. Σφακιανάκης

45m

Digital Humanities
Artificial imagination, imagine: new developments in digital scholarly editingOn edited archives and archived editionsAbstractBuilding on a longstanding terminological discussion in the field of textual scholarship, this essay explores the archival and editorial potential of the digital scholarly edition. Following Van Hulle and Eggert, the author argues that in the digital medium these traditionally distinct activities now find the space they need to complement and reinforce one another. By critically…

Αλέξανδρος Γ. Σφακιανάκης

45m

Cryptology
Generic Attacks on Hash CombinersAbstractHash combiners are a practical way to make cryptographic hash functions more tolerant to future attacks and compatible with existing infrastructure. A combiner combines two or more hash functions in a way that is hopefully more secure than each of the underlying hash functions, or at least remains secure as long as one of them is secure. Two classical hash combiners are the exclusive-or (XOR) combiner \( \mathcal {H}_1(M) \oplus \mathcal {H}_2(M) \) and the…

Αλέξανδρος Γ. Σφακιανάκης

46m

Biochemical Genetics
Analysis of Genetic Diversity and Development of a SCAR Marker for Green Tea ( Camellia sinensis ) Cultivars in Zhejiang Province: The Most Famous Green Tea-Producing Area in ChinaAbstractCamellia sinensis (L.) O. Kuntze is one of the most important non-alcoholic beverage crops in Asian and African countries. In recent years, many green tea cultivars have been released and played an important role in improving the production and quality of tea trees. The objectives of this study were to assess the…

Αλέξανδρος Γ. Σφακιανάκης

47m

Development Genes and Evolution
BioCell2XML : a novel tool for converting cell lineage data from SIMI BioCell to MaMuT (Fiji)AbstractComputer-assisted 4D manual cell tracking has been a valuable method for understanding spatial-temporal dynamics of embryogenesis (e.g., Stach & Anselmi BMC Biol, 13(113), 1–11 2015; Vellutini et al. BMC Biol, 15(33), 1–28 2017; Wolff et al. eLife, 7, e34410 2018) since the method was introduced in the late 1990s. Since two decades SIMI® BioCell (Schnabel et al. Dev Biol, 184, 234–265 1997), a…

Αλέξανδρος Γ. Σφακιανάκης

48m

Orthopaedics
Response to letter to the editor concerning “Orthopaedic surgery patients who use recreational marijuana have less pre-operative pain”Pre-operative virtual simulation and three-dimensional printing techniques for the surgical management of acetabular fracturesAbstractPurposeSurgical treatment of acetabular fractures with plate fixation is challenging for orthopaedic surgeons because of variations of the surface curvature and complex fracture patterns of the acetabulum. We present our experience with…

Αλέξανδρος Γ. Σφακιανάκης

48m

Environmental Contamination and Toxicology
Degradation of Bisphenol A in Natural and Artificial Marine and Freshwaters in TurkeyAbstractBisphenol A (BPA), one of the important synthetic chemicals, has been produced at high volumes since the 1960s. These chemicals are commonly detected in the marine and freshwater environments; however, their transformation in aquatic environments depends on many parameters. This study aims to investigate the degradation of BPA in marine and freshwaters under different conditions in terms of microbial degradation,…

Αλέξανδρος Γ. Σφακιανάκης

49m

Infrared, Millimeter, and Terahertz Waves
Planar Lens–Based Ultra-Wideband Dielectric Rod Waveguide Antenna for Tunable THz and Sub-THz Photomixer SourcesAbstractIn this manuscript, the use of dielectric rod waveguide antenna (DRW) with an embedded planar lens is proposed as a highly directional alternative to an electrically large hyper-hemispheric silicon lens for emission at millimeter and sub-millimeter wave frequencies. DRW antennas radiate properly if only the fundamental mode is excited to the structure. Since photomixer-based terahertz…

Αλέξανδρος Γ. Σφακιανάκης

50m

Perioperative Medicine, Genetic Analysis of Patients Who Experienced Awareness with Recall while under…
Perioperative Medicine,Genetic Analysis of Patients Who Experienced Awareness with Recall while under General AnesthesiaJamie W. Sleigh, M.D.; Kate Leslie, M.D.; Andrew J. Davidson, M.D.; David J. Amor, Ph.D.; Peter Diakumis, M.Bioinf.; Vesna Lukic, M.Sci.; Paul J. Lockhart, Ph.D.; Melanie Bahlo, Ph.D.Anesthesiology Published online July 15, 2019. doi:10.1097/ALN.0000000000002877SPECIAL ARTICLEMusings from an Unlikely Clinician–Scientist: 2018 American Society of Anesthesiologists Excellence in Research…

Αλέξανδρος Γ. Σφακιανάκης

51m

Dharma
Exchange and Transaction as a Form of Life and Meaning in the Logic of Tantric ConceptsAbstractThis essay examines conceptual metaphors from Śaiva-Śākta traditions of Hindu tantra. It explores how conceptual metaphors associated with heterodox ritual exchanges between humans and fierce divinities were employed and used to transform other ideas (bodily fluids, sacrificial products, sexualized symbols, celibacy, states of consciousness, ideas about kinship) to express a new kind of kinship or family…

Αλέξανδρος Γ. Σφακιανάκης

51m

Stem Cell Reviews and Reports
Effects of VEGF + Mesenchymal Stem Cells and Platelet-Rich Plasma on Inbred Rat Ovarian Functions in Cyclophosphamide-Induced Premature Ovarian Insufficiency ModelAbstractPremature ovarian insufficiency (POI), a fertility disorder affecting women under 40 years of age, is characterized by early loss of ovarian function. This study was aimed to maintain ovarian function in POI animal models by mesenchymal stem cells (MSCs) transplantation with/without the supplementation of platelet-rich plasma (PRP)….

Αλέξανδρος Γ. Σφακιανάκης

52m

Radiation Oncology
Letter to the Editor concerning “Re-irradiation in gynaecological cancers, present experiences and future hopes”Challenges in the re-irradiation of locally advanced head and neck cancers: outcomes and toxicitiesAbstractPurposeTo retrospectively review outcomes and toxicities for patients with recurrent head and neck cancer (HNC) undergoing re-irradiation (re-RT).MethodsRetrospective review of oncologic outcomes and toxicity data from patients who received head and neck (HN) re-RT with curative intent…

Αλέξανδρος Γ. Σφακιανάκης

52m

Medical and Biological Engineering
Robot Navigation Using a Brain Computer Interface Based on Motor ImageryAbstractAn interface between a human brain and a computer (or any external device) can be implemented for interchanging orders using a brain–computer interface (BCI) system. Motor imagery (MI), which represents human intention to execute actions or movements, can be captured and analyzed using brain signals such as electroencephalograms (EEGs). The present study focuses on a synchronous control system with a BCI based on MI for…

Αλέξανδρος Γ. Σφακιανάκης

52m

CNS Drugs
Temporal Trends and Predictors of Drug Utilization and Outcomes in First-Ever Stroke Patients: A Population-Based Study Using the Singapore Stroke RegistryAbstractIntroductionDrug utilization and outcomes research in multi-ethnic Asian stroke populations is lacking.ObjectivesOur objective was to examine temporal trends and predictors of drug utilization and outcomes in a multi-ethnic Asian stroke population.MethodsThis registry-based study included ischemic and hemorrhagic first-ever stroke patients…

Αλέξανδρος Γ. Σφακιανάκης

54m

Thyroid-Stimulating Hormone Reference Ranges for Preterm Infants, Dinushan C. Kaluarachchi, David…
Thyroid-Stimulating Hormone Reference Ranges for Preterm Infants,Dinushan C. Kaluarachchi, David B. Allen, Jens C. Eickhoff, Sandra J. Dawe and Mei W. BakerCommentaryAvoiding the Overdiagnosis of Congenital Hypothyroidism in Premature NewbornsFrancisca Grob and Guy Van Vliet

Αλέξανδρος Γ. Σφακιανάκης

56m

IN THIS ISSUE OF JAMA, Highlights Audio Summary: ICU Delirium and PTSD, Protocolized Sepsis Care and…
IN THIS ISSUE OF JAMA,HighlightsAudio Summary: ICU Delirium and PTSD, Protocolized Sepsis Care and Mortality, Time-To-Reperfusion and Stroke Outcomes, and moreORIGINAL INVESTIGATIONCaring for the Critically Ill PatientEffect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical TrialRegis Goulart Rosa, MD, PhD; Maicon Falavigna, MD, PhD; Daiana Barbosa da Silva, RN, MSc; et al.Earn CME creditEditorial: Psychological Consequences of…

Αλέξανδρος Γ. Σφακιανάκης

56m


Clinical Neuropharmacology
Factors Associated With Delirium in Surgical Intensive Care Unit Patients Treated With Supplemental Melatonin: A Case-Cohort StudyObjectives Intensive care unit (ICU) delirium is a common neuropsychiatric syndrome that confers significant morbidity and mortality. Melatonin is an endogenous neurohormone involved with regulating sleep-wake cycles and has been found to be disturbed in ICU delirium. We hypothesized that there are independent factors that predict delirium in a cohort of patients on melatonin…

Αλέξανδρος Γ. Σφακιανάκης

58m


Journal of Surgical Oncology Early View Online Version of Record before inclusion in an issue Race,…
Journal of Surgical OncologyEarly ViewOnline Version of Record before inclusion in an issueRace, ethnicity, and socioeconomic factors in cholangiocarcinoma: What is driving disparities in receipt of treatment?Rachel M. Lee MD, MSPH, Yuan Liu PhD, Adriana C. Gamboa MD, Mohammad Y. Zaidi MD, MS, David A. Kooby MD, FACS, Mihir M. Shah MD, Kenneth Cardona MD, FACS, Maria C. Russell MD, FACS, Shishir K. Maithel MD, FACSVersion of Record online: 13 July 2019A prediction model for lymph node metastasis…

Αλέξανδρος Γ. Σφακιανάκης

58m


Pathological Gambling Associated With Aripiprazole Objectives Pathological gambling can be potentiated…
Pathological Gambling Associated With Aripiprazole Objectives Pathological gambling can be potentiated by treatment with dopamine agonists. Aripiprazole, bearing a partial agonist activity at dopamine D2 and D3 receptors, has also been linked to such a behavioral aberration, usually on subjects predisposed with tendency of impulsive or addictive behaviors. Methods Review of patient’s medical records and literature review. Results Two young patients’ pathological gambling emerged simply due to…

Αλέξανδρος Γ. Σφακιανάκης

59m

Sertraline-Related Amenorrhea in an Adolescent Amenorrhea is one of the clinical consequences of hyperprolactinemia….
Sertraline-Related Amenorrhea in an Adolescent Amenorrhea is one of the clinical consequences of hyperprolactinemia. Although symptomatic hyperprolactinemia is among the well-described adverse reactions of antipsychotic agents, it may also be reported with the use of selective serotonin reuptake inhibitors. Hereby, we present a case of sertraline-related hyperprolactinemic amenorrhea in an adolescent. Amenorrhea occurred 2 months after starting sertraline, and menstrual cycle restored after stopping…

Αλέξανδρος Γ. Σφακιανάκης

59m

Levetiracetam-Related Mania-Like Symptoms: An Adolescent Case Levetiracetam is an antiepileptic agent…
Levetiracetam-Related Mania-Like Symptoms: An Adolescent CaseLevetiracetam is an antiepileptic agent that is used for partial and generalized epilepsy. Although it is well tolerated in most cases, behavioral and nonbehavioral adverse effects may be observed. Among behavioral symptoms, depression, hostility, and agitation have been frequently reported. However, mania or mania-like symptoms are relatively rare, especially in children and adolescents. Hereby, we report mania-like symptoms with levetiracetam…

Αλέξανδρος Γ. Σφακιανάκης

1h


Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A…
Drug-Induced Parkinsonism Manifesting as Gait Freezing in a Patient With Traumatic Brain Injury: A Case ReportBackground Among the neuropsychiatric complications commonly induced by traumatic brain injury (TBI), behavioral disorders, such as agitation and aggression, can hinder neurological recovery and deteriorate rehabilitation outcomes. Pharmacological treatment for behavioral disorders might be beneficial but could lead to drug-induced parkinsonism. We report a case of a patient with drug-induced…

Αλέξανδρος Γ. Σφακιανάκης

1h


Therapeutic Drug Monitoring
Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot–Based Methods for Therapeutic Drug MonitoringAbstract: Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality of bioanalytical methods, the design, development and validation needs to fit the intended use. Current validation requirements, described…

Αλέξανδρος Γ. Σφακιανάκης

1h


Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely Source Adelman, Madeline, BS*;…
Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely SourceAdelman, Madeline, BS*; Mohammad, Tasneem, MD†; Kerr, Holly, MD†Dermatitis: May/June 2019 – Volume 30 – Issue 3 – p 230–231doi: 10.1097/DER.0000000000000470PEARLS & ZEBRASBenzoyl peroxide is effective for reducing the number and severity of acne lesions. It has a bactericidal effect on Cutibacterium acnes bacteria associated with acne and does not induce antibiotic resistance.[11][12] It may be combined with salicylic…

Αλέξανδρος Γ. Σφακιανάκης

1h


Nursing Research
Maintaining and Improving Psychological Well-BeingNo abstract availableMediating Effects of Social Support on Depression and Suicidal Ideation in Older Korean Adults With Hypertension Who Live AloneBackground: Older adults who live alone are less physically and emotionally healthy and report higher levels of depression relative to those who do not live alone. Suicide is the most problematic health issue reported by older adults who live alone. In particular, vulnerable older adults who live alone…

Αλέξανδρος Γ. Σφακιανάκης

1h


Bathing Additives for Atopic Dermatitis — A Systematic Review Bathing additives are regularly used…
Bathing Additives for Atopic Dermatitis — A Systematic ReviewBathing additives are regularly used for a range of inflammatory dermatoses that affect a large body surface area. Emerging evidence demonstrates that certain bathing additives have anti-inflammatory, skin barrier repair, antimicrobial, and antioxidative properties, all pertinent to atopic dermatitis. This review summarizes the mechanism and effects of Dead Sea salt, hard water, commercial baby cleansers, oatmeal, rice, and natural oils…

Αλέξανδρος Γ. Σφακιανάκης

1h


Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New? Poison ivy, poison oak, and poison…
Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?Poison ivy, poison oak, and poison sumac are the most common causes of clinically diagnosed allergic contact dermatitis in North America. Approximately 50% to 75% of the US adult population is clinically sensitive to poison ivy, oak, and sumac. We reviewed the botany and history of these plants; urushiol chemistry and pathophysiology, clinical features, and the prevalence of allergic contact dermatitis caused by these plants; and…

Αλέξανδρος Γ. Σφακιανάκης

1h


Dermatitis
SELF-ASSESSMENTNo abstract availablePoison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?Poison ivy, poison oak, and poison sumac are the most common causes of clinically diagnosed allergic contact dermatitis in North America. Approximately 50% to 75% of the US adult population is clinically sensitive to poison ivy, oak, and sumac. We reviewed the botany and history of these plants; urushiol chemistry and pathophysiology, clinical features, and the prevalence of allergic contact dermatitis…

Αλέξανδρος Γ. Σφακιανάκης

1h


Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta:…
Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta: A Case ReportWe describe the management of a pregnant patient with osteogenesis imperfecta with a history of numerous fractures, severe scoliosis, and anticipated difficult airway. Her pregnancy was complicated by progressive shortness of breath and a fetal diagnosis of osteogenesis imperfecta. Spine anatomy precluded neuraxial anesthesia. Cesarean delivery was performed under general anesthesia…

Αλέξανδρος Γ. Σφακιανάκης

1h


Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage:…
Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage: A Case ReportTreacher Collins syndrome is an inherited disorder resulting in maldevelopment of the first and second branchial arches. Patients have complex orofacial anatomy often requiring airway interventions from birth. A 17-year-old boy with Treacher Collins syndrome and history of difficult ventilation and intubation presented for elective maxillofacial reconstruction. After uneventful awake…

Αλέξανδρος Γ. Σφακιανάκης

1h


Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case Report Esophageal…
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case ReportEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged…

Αλέξανδρος Γ. Σφακιανάκης

1h

Rare electrosurgical complications in tonsillectomy: Analysis of national adverse event reporting Alisa…
Rare electrosurgical complications in tonsillectomy: Analysis of national adverse event reportingAlisa Yamasaki MD Neil Bhattacharyya MD, FACSFirst published: 11 July 2019 https://doi.org/10.1002/lary.28181Editor’s Note: This Manuscript was accepted for publication on June 24, 2019.Presented as an oral presentation at the Triological Society Combined Sections Meeting 2019, Coronado, California, U.S.A., January 24–26, 2019.The authors have no funding, financial relationships, or conflicts of interest…

Αλέξανδρος Γ. Σφακιανάκης

1h

Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy, Avigeet Gupta BS Sina…
Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy,Avigeet Gupta BS Sina Koochakzadeh BS David M. Neskey MD, MSCR Shaun A. Nguyen MD, MA Eric J. Lentsch MDFirst published: 10 July 2019 https://doi.org/10.1002/lary.28183Editor’s Note: This Manuscript was accepted for publication on June 24, 2019.The authors have no funding, financial relationships, or conflicts of interest to disclose.Read the full textePDFPDFTOOLS SHAREAbstractObjectives/HypothesisCarcinosarcomas represent…

Αλέξανδρος Γ. Σφακιανάκης

1h

Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysis, Mathieu Bergeron…
Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysis,Mathieu Bergeron BPharm, MD, FRCSC Katherine Chang BS Stacey L. Ishman MD, MPHFirst published: 13 July 2019 https://doi.org/10.1002/lary.28169Editor’s Note: This Manuscript was accepted for publication on June 13, 2019.The authors have no funding, financial relationships, or conflicts of interest to disclose.Read the full textePDFPDFTOOLS SHAREAbstractObjectivesCornelia de Lange syndrome (CdLS) is a rare genetic…

Αλέξανδρος Γ. Σφακιανάκης

1h


Anaesthesia
Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case ReportEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged…

Αλέξανδρος Γ. Σφακιανάκης

1h


The Laryngoscope Early View Online Version of Record before inclusion in an issue Pattern and severity…
The LaryngoscopeEarly ViewOnline Version of Record before inclusion in an issuePattern and severity of transverse sinus stenosis in patients with pulsatile tinnitus associated with sigmoid sinus wall anomaliesDaniel Hewes MD, Robert Morales MD, Prashant Raghavan MBBS, David J. Eisenman MDVersion of Record online: 13 July 2019Cornelia de lange manifestations in otolaryngology: A systematic review and meta‐analysisMathieu Bergeron BPharm, MD, FRCSC, Katherine Chang BS, Stacey L. Ishman MD, MPHVersion…

Αλέξανδρος Γ. Σφακιανάκης

1h


Oncology – Spandidos Publications
Suicide gene‑armed measles vaccine virus for the treatment of AMLStefanie Maurer, Helmut R. Salih, Irina Smirnow, Ulrich M. Lauer, Susanne BerchtoldView Abstract ❯SOX4 regulates invasion of bladder cancer cells via repression of WNT5aJosue D. Moran, Hannah H. Kim, Zhenghong Li, Carlos S. MorenoView Abstract ❯Prognostic significance of VHL, HIF1A, HIF2A, VEGFA and p53 expression in patients with clear‑cell renal cell carcinoma treated with sunitinib as first‑line treatmentPiotr M. Wierzbicki, Jakub…

Αλέξανδρος Γ. Σφακιανάκης

1h


Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Microbial EcologyTaurine Is a Major Carbon and Energy Source for Marine Prokaryotes in the North Atlantic Ocean off the Iberian PeninsulaAbstractTaurine, an amino acid-like compound, acts as an osmostress protectant in many marine metazoans and algae and is released via various processes into the oceanic dissolved organic matter pool. Taurine transporters are widespread among members of the marine prokaryotic community, tentatively indicating that taurine might be an important substrate for prokaryotes…

Αλέξανδρος Γ. Σφακιανάκης

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Blood Cells, Molecules, and Diseases
Predictors of autoimmune hemolytic anemia in beta-thalassemia patients with underlying red blood cells autoantibodiesPublication date: November 2019Source: Blood Cells, Molecules, and Diseases, Volume 79Author(s): Monia Ben Khaled, Monia Ouederni, Nessrine Sahli, Nawel Dhouib, Ahmed Ben Abdelaziz, Samia Rekaya, Ridha Kouki, Houda Kaabi, Hmida Slama, Fethi Mellouli, Mohamed BejaouiAbstractIn beta-thalassemia patients, erythrocyte autoantibodies can remain silent or lead to Autoimmune Hemolytic Anemia…

Αλέξανδρος Γ. Σφακιανάκης

1d

Clinical Nuclear Medicine
Unexpected Lymphatic Drainage of the Treated BreastThis case highlights the use of lymphoscintigraphy with SPECT/CT in patients with previous chest and/or axillary surgery. A 67-year-old woman with a history of left breast carcinoma treated with lumpectomy and radiotherapy, and a second lumpectomy of the ipsilateral breast for a second breast carcinoma, underwent a lymphoscintigraphy for a new left breast lesion. Planar images visualized an alternative lymphatic drainage to the contralateral axilla…

Αλέξανδρος Γ. Σφακιανάκης

1d


Applied Immunohistochemistry & Molecular Morphology
Comparison of Dako HercepTest and Ventana PATHWAY Anti-HER2 (4B5) Tests and Their Correlation With Fluorescent In Situ Hybridization in Breast CarcinomaObjectives: We compared the performance of two Food and Drug Administration–approved HER2 immunohistochemistry (IHC) tests: HercepTest (Dako) and PATHWAY anti-HER2 (4B5) (Ventana). Materials and Methods: In total, 180 invasive breast carcinomas previously tested by both HercepTest and fluorescent in situ hybridization (FISH) were retested with 4B5….

Αλέξανδρος Γ. Σφακιανάκης

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Coronary Artery Disease
Beneficial effect of ticagrelor on microvascular perfusion in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary interventionBackground Ticagrelor significantly reduced the incidence of death, myocardial infarction, and stent thrombosis in patients with ST-segment elevation myocardial infarction (STEMI) intended for reperfusion with a primary percutaneous coronary intervention (pPCI). However, the effects of this drug on microvascular perfusion in…

Αλέξανδρος Γ. Σφακιανάκης

1d


Diseases of the Colon & Rectum
Drs Julio Garcia-Aguilar and Emina Huang: Colorectal Surgeons Advancing the Science of Colorectal DiseasesNo abstract availableEvaluation and Management of Enterocutaneous FistulaCase Summary: A 36-year-old woman presents with an abscess at her midline wound 4 weeks following an ileocecectomy for Crohn’s disease. After the abscess is incised, there is purulent drainage followed by the drainage of enteric contents; the output is 750 mL per 24 hours.Expert Commentary on the Management of Enterocutaneous…

Αλέξανδρος Γ. Σφακιανάκης

1d


Pancreas
The 49th Annual Meeting of the American Pancreatic Association in Collaboration With the International Association of PancreatologyNo abstract availableNext-Generation Sequencing in Pancreatic CancerPancreatic ductal adenocarcinoma (PDAC) is lethal, and the majority of patients present with locally advanced or metastatic disease that is not amenable to cure. Thus, with surgical resection being the only curative modality, it is critical that disease is identified at an earlier stage to allow the appropriate…

Αλέξανδρος Γ. Σφακιανάκης

1d

NeuroReport
Cellular, Molecular and Developmental NeuroscienceOffline beats online transcranial direct current stimulation timing influences on working memoryFriehs, Maximilian A.; Frings, ChristianNeuroReport. 30(12):795-799, August 14, 2019.AbstractFavorites PDF Get Content & PermissionsThe n-back task is an established measure of an individual’s working memory. In this task, participants have to continuously update their working memory to react to a stimulus correctly. For the verbal n-back task in particular,…

Αλέξανδρος Γ. Σφακιανάκης

1d

Shock
Collapse Box Clinical Science AspectsAssociation of Sex With Clinical Outcome in Critically Ill Sepsis Patients A Retrospective Analysis of the Large Clinical Database MIMIC-IIIXu, Jinghong; Tong, Li; Yao, Jiyou; MoreShock. 52(2):146-151, August 2019.AbstractFavoritesPDF Get Content & PermissionsIntroduction:The objective of our study was to explore the association between sex and clinical outcome in sepsis patients in a large, diverse population.Materials and Methods:We analyzed 6,134 adult…

Αλέξανδρος Γ. Σφακιανάκης

1d


Pediatric Infectious Diseases
Multidrug-resistant Gram-negative Bacterial Bloodstream Infections in Children’s Hospitals in Japan, 2010–2017Background: The risk factors of multidrug-resistant (MDR) Gram-negative bacilli (GNB) bloodstream infection (BSI) are not yet known in children. Our aim was to evaluate risk factors and outcomes associated with MDR GNB BSI in children. Methods: Patients with GNB BSI were enrolled between April 2010 and March 2017 at 8 children’s hospitals in Japan. Clinical and microbiologic data were collected…

Αλέξανδρος Γ. Σφακιανάκης

1d

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
SCCMPediatric Critical Care MedicineCritical Care Explorations, https://journals.lww.com/ccmjournal/toc/publishahead,…SCCMPediatric Critical Care MedicineCritical Care Explorations,https://journals.lww.com/ccmjournal/toc/publishahead,Online First – Last Updated: July 15, 2019The editors of this journal are pleased to offer electronic publication of accepted papers prior to print publication. These papers can be cited using the date of access and the unique DOI number. Any final changes in manuscripts…

Αλέξανδρος Γ. Σφακιανάκης

1d

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Nursing Research

Maintaining and Improving Psychological Well-Being
No abstract available
Mediating Effects of Social Support on Depression and Suicidal Ideation in Older Korean Adults With Hypertension Who Live Alone
imageBackground: Older adults who live alone are less physically and emotionally healthy and report higher levels of depression relative to those who do not live alone. Suicide is the most problematic health issue reported by older adults who live alone. In particular, vulnerable older adults who live alone experience difficulty obtaining self-care and medical services; therefore, early detection of depression is difficult, and there are few opportunities to implement suicide prevention strategies in this population. In addition, social support for depression is an important factor affecting illness and economic vulnerability in older adults who live alone. Purpose: This study aimed to examine the relationship between depression and suicidal ideation in vulnerable older Korean adults with hypertension and to explore the mediating effect of social support on this relationship. Methods: The study used a cross-sectional design. Vulnerable older adults who were 65 years old or older with hypertension and who received home visit services from a public health center were invited to participate. The participants completed structured questionnaires, including the 15-item Short-Form Geriatric Depression Scale, 12-item Multidimensional Scale of Perceived Social Support, and 19-item Scale for Suicidal Ideation, and provided information regarding their demographic characteristics, health status, and economic status. Descriptive and correlation analyses were performed to examine the correlations among these variables. The three-step regression analysis method proposed by Baron and Kenny was used to examine the mediating effect of social support. Results: The mean depression, social support, and suicidal ideation scores of participants were 23.64 (± 2.04), 35.94 (± 15.40), and 7.80 (± 7.73), respectively. In addition, depression was negatively correlated with social support (r = −.27) and positively correlated with suicidal ideation (r = .21), whereas social support was negatively correlated with suicidal ideation (r = −.35). Social support mediated the relationship between depression and suicidal ideation (Z = 2.69). Conclusions: Social support was identified as an important variable for older adults with chronic illness who lived alone. Interventions that include social support hold the potential to reduce depression and suicidal ideation in this population.
Comparisons of Health Promoting Behavior, Depression, and Life Satisfaction Between Older Adults in Rural Areas in South Korea Living in Group Homes and at Home
imageBackground: In South Korea, population aging is advancing at a more rapid rate in rural areas than urban areas, leading to a particularly high percentage of rural-dwelling older adults. Purpose: The aim of this study was to examine and compare health promoting behaviors, depression, and life satisfaction between rural-dwelling older adults who live, respectively, in group homes and at home. Methods: A cross-sectional descriptive study design was employed. Study participants included 160 older adults aged 65 years and older who were living in group homes (n = 80) and at home (n = 80) in Gyeonggi province, South Korea. The Health Promotion Lifestyle Profile-II was used to examine health promoting behaviors, the Korean Geriatric Depression Screening Scale was used to examine depression, and the Life Satisfaction Index was used to examine life satisfaction. Data were analyzed using SPSS Version 21.0. Results: The data showed significant differences between the two groups in terms of health promoting behaviors (t = −9.035, p < .001), depression (t = 20.861, p < .001), and life satisfaction (t = −12.153, p < .001). Conclusions/Implications for Practice: The mean scores for health promotion behaviors and life satisfaction were higher, and the mean score for depression was lower in the group-home group than the at-home group. The findings from this study may be employed as basic data for establishing residence-appropriate nursing intervention protocols for older adults living in rural areas.
Investigation of the Experiences of Mothers Living Through Prenatal Loss Incidents: A Qualitative Study
imageBackground: Fetal death causes women to experience negative feelings after the loss. These lived experiences influence the future pregnancies and maternal health of women negatively. Purpose: The aim of this study was to investigate the experiences of women whose pregnancies were terminated because of medical indications. Methods: A “design for definitive status study” type of qualitative research design was used. Ten women who were hospitalized between April and July 2017 at the Akdeniz University Clinic of Obstetrics and Gynecology and had subsequently experienced pregnancy loss during their hospitalization were enrolled as participants. Thematic analysis was used to analyze the data. Results: The pregnancy loss experiences of participants were investigated under the five main themes of (a) lived experiences before the termination of pregnancy, (b) lived experiences after pregnancy termination, (c) willingness to see the baby after termination, (d) posttermination care requirements, and (e) physical condition of hospital rooms during hospitalization. The participants expressed feelings of hope, fear, and worry over being unsuccessful before fetal death and feelings of loneliness, disappointment, blame, and avoidance after fetal death. Conclusions/Implications for Practice: In the aftermath of fetal death, health professionals should use insightful and empathic communication skills to help mothers cope with their loss. In addition, some of the participants wanted to see their babies, and some did not. Thus, individualized care is very important for women who experience pregnancy loss.
Alcohol Consumption as a Moderator of Anxiety and Sleep Quality
imageBackground: Although people who sleep poorly may attempt to relieve anxiety for better sleep quality, whether daily alcohol consumption is a factor that moderates anxiety and sleep disturbance is not known. Purpose: The aim of the study was to explore (a) the association between anxiety and sleep quality and (b) whether daily alcohol consumption acted as a moderator between anxiety and sleep quality in those who reported sleeping poorly. Methods: Eighty-four participants aged 20–80 years who reported poor sleep (Pittsburgh Sleep Quality Index > 5) in northern Taiwan were enrolled in this cross-sectional study. A structured questionnaire covering demographics (including daily alcohol consumption), level of anxiety, level of depression, and perceived sleep quality was used to collect data. Results: The participants were mostly women (72.6%). The mean age was 41.81 (SD = 12.62) years; 51.2%, 19.0%, 13.1%, and 14.3%, respectively, had minimal, mild, moderate, and severe anxiety. After adjusting for factors related to sleep quality using multiple regression analysis, receiving sleep therapy, consuming alcohol on a daily basis, and having anxiety were found to be predictors of poor sleep quality. Moreover, daily alcohol consumption was found to moderate the relationship between anxiety and sleep quality. Conclusions/Implications for Practice: People who sleep poorly should avoid misusing alcohol to self-treat poor sleep quality or anxiety and should instead utilize sleep hygiene education and mental healthcare. Daily alcohol consumption may be a moderator between anxiety status and sleep quality.
Predictors of Caregiver Burden in Caregivers of Bedridden Patients
imageBackground Caregivers are at risk of experiencing caregiver burden. It is therefore important to determine the caregiver burden of caregivers who provide care to bedridden patients and related factors. Purpose The aim of this study was to determine the caregiver burden of caregivers who provide care to bedridden patients and the factors that impact this burden. Methods This cross-sectional study was executed at a state hospital in Istanbul, Turkey, on bedridden patients registered in the home healthcare unit and their caregivers. During study period, the researchers made 312 visits to patients and their caregivers. A sociodemographic questionnaire, the Burden Interview, and the Katz Index of Independence in Activities of Daily Living were used to collect data. Descriptive statistics, an independent sample t test, one-way analysis of variance, and stepwise multiple regression analysis were used for data analysis. Results The participants reported a moderate level of caregiver burden. Existing caregiver health problems, caregiver employment status, the ability of the caregiver to maintain his or her own good health, type of home, and the degree of patient dependence in terms of activities of daily living were each found to be significant predictors of caregiver burden. Conclusions/Implications of Practice The support provided to caregivers by home healthcare units is important in terms of protecting the physical, mental, and social health conditions of caregivers and preventing the exacerbation of caregiver burden.
The Relationship Between the Quality of Work and Organizational Commitment of Prison Nurses
imageBackground: Nurses working in prisons are exposed to security problems while serving those who may be uninterested in their own healthcare, face high risks of drug and alcohol addiction, and may have aggressive personalities. For this reason, nurses working in prisons may have more problems with work-related quality of life than their non-prison-nurse peers. Purpose: This descriptive research study was conducted to evaluate the work-related quality of life and organizational commitment of nurses who work at prisons and detention centers. Methods: According to 2015 data, approximately 513 nurses currently work in prisons in Turkey. The study group consisted of 224 nurses who currently work in prisons or detention centers. The data were collected by sending a created link address to the e-mail addresses of nurses who work in these facilities. A 13-item sociodemographic information form, including a demographics datasheet, a work-related quality of life scale, and an organizational commitment scale, was used to collect data. Results: The participants reported a moderate level of work-related quality of life and organizational commitment. Moreover, work-related quality of life was shown to affect organizational commitment, with 20% of the total variance in organizational commitment explained by work-related quality of life. Conclusions/Implications for Practice: This study supports that work-related quality of life affects organizational commitment positively. Therefore, regulating working conditions by taking into consideration employee security will positively affect job satisfaction in terms of both the institution and the employee. Moreover, as nurses do not only work in hospitals, taking this action should also work in different settings. Administrators should ensure the work-related quality of life of the prison nurses by understanding the difficulties of prison nursing.
Stress, Workplace Violence, and Burnout in Nurses Working in King Abdullah Medical City During Al-Hajj Season
imageBackground: The Hajj pilgrimage to Mecca, one of the largest mass gatherings in the world, is associated with various challenges for nurses. One of these challenges is increased levels of workplace violence. Therefore, handling and mitigating workplace violence against nurses during Hajj, when nurses face a higher risk of violence and most experience stress and burnout, is of particular importance. Purpose: The aims of this study were to identify the types and sources of workplace violence, examine the relationship between burnout in nurses and the variables of stress and workplace violence, and identify from the perspective of nurses measures to effectively handle and mitigate these issues during Hajj season. Methods: This study used a descriptive correlational design. A convenience sample of 118 nurses completed the Perceived Stress Scale, the Maslach Burnout Inventory, and the modified version of the Joint Programme on Workplace Violence in the Health Sector published by the International Labour Office in Geneva. Data analysis was done using an independent samples t test and Pearson product–moment correlation. Results: One hundred eighteen nurses completed the study. Over two thirds (65%) were female, and 56% reported experiencing at least one type of violence, of which bullying/mobbing, racial harassment, threats, and physical violence accounted for 61%, 15%, 12%, and 12%, respectively. Nurse managers displayed violent behaviors against 54% of the participants. Participants reported high levels of stress and burnout. A positive relationship was found between stress and emotional exhaustion (r = .387, p < .01). Providing effective security measures and staff training regarding how to deal with violence at the workplace were the main measures identified to help reduce workplace violence. Conclusions: Providing effective security measures and tailored intervention programs addressing how to deal with violence in the workplace may enable nurses to handle violent behaviors more effectively.
Using a Text Mining Approach to Explore the Recording Quality of a Nursing Record System
imageBackground: Most nursing records in Taiwan have been computerized, resulting in a large amount of unstructured text data. The quality of these records has rarely been discussed. Purpose: This study used a text mining method to analyze the quality of a nursing record system to establish an auditing model and associated tools for nursing records, with the ultimate objective of improving the quality of electronic nursing records. Methods: This study utilized a retrospective method to collect the electronic nursing records of 6,277 patients who had been discharged from the internal medicine departments of a medical center in northern Taiwan from January to June 2014. SAS Enterprise Guide Version 6.1 and SAS Text Miner Version 13.2 software were used to perform text mining. Nursing experts were invited to examine the electronic nursing records. The text mining results were compared against a benchmark that was developed by the experts, and the efficiency of SAS Text Miner was examined using the criteria of specificity, sensitivity, and accuracy. Results: In this study, 27,356 nurse-formulated events were used in the analysis. The results of the nurse-formulated events showed an 8.08% similar error with system-formulated events, 29.72% were identified as necessary and appropriate names, 17.53% were retained, 10.15% involved error event names, and 34.52% were not classified. In this study, the sensitivity of SAS text mining in the training (testing) data set was 96% (95%), and the specificity and accuracy were both 99% (99%). Conclusions: The results of this study show that text mining is an effective approach to auditing the quality of electronic nursing records. SAS Text Miner software was shown to identify inappropriate nursing record content quickly and efficiently. Furthermore, the results of this study may be included in in-service education teaching materials to promote the writing of better nursing records to improve the quality of electronic nursing records.
Frail Phenotype and Disability Prediction in Community-Dwelling Older People: A Systematic Review and Meta-Analysis of Prospective Cohort Studies
imageBackground: The World Health Organization has identified frailty as a crucial factor affecting successful aging. Systematic literature reviews have yet to focus on the relationship between stages of frailty and disability in community-dwelling older adults. Purpose: The purpose of this study was to investigate the relationships between various frailty types and disability in community-dwelling older adults and to explore how various frailty criteria have been used to assess disability in this population. Methods: A systematic literature review and meta-analysis were conducted on articles from the following databases: Cochrane Library, CINAHL, PubMed, and Ovid. Database search criteria included articles that were published between January 2001 and July 2017 and study samples that included community-dwelling adults aged 60 years and older. We excluded studies that were conducted in institutions or hospitals and experimental studies on frailty. Two reviewers independently assessed eligibility and extracted data. A random-effects model was used to analyze the literature and to calculate the pooled disability of frailty. Results: In total, nine studies with a total sample of 32,998 participants that recorded 8,666 disabilities and a mean follow-up time of 30.4 months (SD = 29.26) were pooled for the meta-analysis. Using various indicators to predict the risk of disability compared with robust older adults, those with frailty faced a higher risk of disability, followed by older adults at risk of frailty. Conclusions/Implications for Practice: Frailty is a crucial health consideration among older adults. Those who are frail have the highest relative risk of disability, followed by those at risk of frailty. Early assessment of frailty may effectively prevent the occurrence of frailty-induced disability in older adults.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Nursing Research

Dermatitis

SELF-ASSESSMENT
imageNo abstract available
Poison Ivy, Oak, and Sumac Dermatitis: What Is Known and What Is New?
imagePoison ivy, poison oak, and poison sumac are the most common causes of clinically diagnosed allergic contact dermatitis in North America. Approximately 50% to 75% of the US adult population is clinically sensitive to poison ivy, oak, and sumac. We reviewed the botany and history of these plants; urushiol chemistry and pathophysiology, clinical features, and the prevalence of allergic contact dermatitis caused by these plants; and current postexposure treatment and preventive methods, including ongoing investigations in the development of a vaccine (immunotherapy). Although extensive efforts have been made to develop therapies that prevent and treat contact dermatitis to these plants, there lacks an entirely effective method, besides complete avoidance. There is a need for a better therapy to definitively prevent allergic contact dermatitis to these plants.
Bathing Additives for Atopic Dermatitis — A Systematic Review
imageBathing additives are regularly used for a range of inflammatory dermatoses that affect a large body surface area. Emerging evidence demonstrates that certain bathing additives have anti-inflammatory, skin barrier repair, antimicrobial, and antioxidative properties, all pertinent to atopic dermatitis. This review summarizes the mechanism and effects of Dead Sea salt, hard water, commercial baby cleansers, oatmeal, rice, and natural oils as bathing additives for the treatment of atopic dermatitis. The use of these compounds seems to augment the benefit of traditional treatments while also reducing the need for and side effects of prescription modalities. Bathing additives are useful adjuvant treatments for atopic dermatitis. Benefits of these compounds are derived from anti-inflammatory, antimicrobial, antioxidative, and skin barrier repair properties.
Effects of Merino Wool on Atopic Dermatitis Using Clinical, Quality of Life, and Physiological Outcome Measures
imageBackground Wool clothing may be perceived as a poor choice for use by individuals with sensitive skin or atopic dermatitis. Objectives The aims of the study were to evaluate the effect on atopic dermatitis of wearing fine Merino wool clothing versus standard clothing and to assess the effect of Merino wool clothing on quality of life in children and adults with atopic dermatitis 5 years and older. Methods Subjects with mild to moderate atopic dermatitis were assessed in a crossover fashion after wearing Merino wool clothing for 6 weeks and standard clothing for 6 weeks, for Eczema Area and Severity Index, Dermatology Life Quality Index, static Investigator’s Global Assessment, and skin hydration. Results While wearing Merino wool clothing, compared with standard clothing, statistically significant improvements were seen in mean Eczema Area and Severity Index scores, Dermatology Life Quality Index scores, and static Investigator’s Global Assessment scores. No significant difference was seen with skin hydration. Wearing Merino wool clothing did not produce any negative cutaneous effects compared with wearing standard clothing. Conclusions Merino wool clothing compared with standard clothing provided improvements in severity of atopic dermatitis as well as quality of life in atopic patients.
Formaldehyde Release From Baby Wipes: Analysis Using the Chromotropic Acid Method
imageBackground Formaldehyde is a common preservative and strong sensitizer. Objective The aim of the study was to evaluate the release of formaldehyde from baby/toddler wet wipes using the chromotropic acid method (CAM). Methods An online search of best-selling baby wipes was conducted. None declared formaldehyde or formaldehyde-releasing preservatives. Standard CAM procedures were used: a 1 × 1-in square of fresh wipe was placed in a bottle with an open vial of 4 mg/1 mL of chromotropic acid and sulfuric acid solution, sealed, and stored for 48 hours. Formalin and water served as controls. A blinded investigator graded color change (negative, indeterminate, mild, moderate, or strong). For quality control, 20% of all samples as well as all positives were retested. Results Fifty-one popular and highly reviewed baby and toddler wet wipe products were tested using CAM. Twelve wipes (24%) released formaldehyde (8 mild, 4 moderate/strong). Chromotropic acid method testing of 9 wipes (18%) was indeterminate and 30 (59%) were negative. Conclusions Almost one quarter of baby/toddler wet wipes released formaldehyde when evaluated with CAM. Patients and clinicians should be aware of this potentially undeclared source of this common allergen.
Cross-sectional Survey of Nickel Allergy Management in the Context of Intracardiac Device Implantation
imageBackground The occlusion devices used for repair of atrial septal defect and patent foramen ovale commonly contain nitinol, an alloy containing nickel. There are reports of nickel allergy in the context of intracardiac device implantation. Type IV delayed-type reactions likely predominate in intracardiac metal hypersensitivity, but there are potentially other mechanisms such as cytotoxic or innate immunity. Based on available literature to date, the significance of nickel allergy in intracardiac occluders remains unclear. Objective The aim of the study was to investigate nickel allergy management strategies in intracardiac occluders. Methods The American Contact Dermatitis Society facilitated distribution of a survey via e-mail to the members of its association, which included dermatologists and allergists/immunologists. A total of 70 individuals answered the survey. Conclusions There was no consensus regarding the ability of patch testing to accurately determine allergic reactions within cardiac tissue. There was also no agreement on the criteria for patch testing in patients undergoing intracardiac implantation. However, most would inquire about a history of contact sensitivity to previously implanted devices. With a positive patch test, nickel-based intracardiac devices should be avoided, or the decision should be left to the discretion of the cardiologist.
Screening for Gold Sensitization in Consecutive Eczema Patients: Prevalence, Relevance, and Sources of Exposure
imageBackground Since the 1990s, gold has been recognized as an important contact allergen. Objectives Based on our results with gold sodium thiosulfate (GST) in the TRUE Test patch test system in the baseline series, the aims of the study were to evaluate baseline testing with gold salts worldwide and to discuss relevance. Methods Patients with positive patch test reactions to GST were questioned on exposure at day 7 reading. Results In a 1-year period, 89 (18.5%) of 480 patients tested positive to GST, making this the most frequent contact allergy. The 89 patients comprised 18 males and 71 females. The reaction was considered relevant in 21%; this is a minimum figure because 2 patients were withdrawn because of unknown relevance and because clinical features suggestive of gold contact allergy at distant sites, such as the face, were not taken into account. Altogether, 88% had been exposed. Worldwide, the prevalence of gold sensitization ranges between 0.78% and 30.7%, and relevance, in larger studies, has been between 15% and 20% of patients. The use of earrings and the presence of dental gold were important sources of exposure. Conclusions Because it may be difficult to diagnose gold allergy, screening may be recommended when history taken suggests gold exposure.
Allergic Contact Dermatitis to Licorice Root Extract
imageNo abstract available
Oh My Glucosides! Occult Sources in Medical Products
imageNo abstract available
Allergic Contact Dermatitis Due to Benzoyl Peroxide From an Unlikely Source
imageNo abstract available

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Dermatitis

Anaesthesia

Retrieval of a Esophageal pH Monitoring Probe Dislodged Into the Laryngopharynx: A Case Report
imageEsophageal pH monitoring via wireless probes is used to evaluate chest pain and atypical symptoms and diagnose gastroesophageal reflux. These probes are commonly placed during esophagogastroduodenoscopy performed by gastroenterologists in an ambulatory anesthesia setting. Dislodgment and aspiration of these probes can cause morbidity, require surgical removal, and involve the anesthesia provider in prolonged emergency care. We present a case of a probe dislodgment where aspiration was avoided and describe how retrieval of this device is different from typical hypopharyngeal foreign body removal.
Urgent Complex Intraoperative Reintubation in a Known Difficult Airway After Endotracheal Tube Damage: A Case Report
imageTreacher Collins syndrome is an inherited disorder resulting in maldevelopment of the first and second branchial arches. Patients have complex orofacial anatomy often requiring airway interventions from birth. A 17-year-old boy with Treacher Collins syndrome and history of difficult ventilation and intubation presented for elective maxillofacial reconstruction. After uneventful awake nasal fiberoptic intubation, the nasotracheal tube was damaged intraoperatively. Due to the patient’s unique anatomy, a fiberoptic bronchoscope and ventilating exchange catheter were utilized together to facilitate a nasotracheal tube exchange. This case demonstrates the utilization of a combination of advanced airway techniques in an urgent perioperative setting.
Supraglottic Airway Rescue After Failed Fiberoptic Intubation in a Patient With Osteogenesis Imperfecta: A Case Report
imageWe describe the management of a pregnant patient with osteogenesis imperfecta with a history of numerous fractures, severe scoliosis, and anticipated difficult airway. Her pregnancy was complicated by progressive shortness of breath and a fetal diagnosis of osteogenesis imperfecta. Spine anatomy precluded neuraxial anesthesia. Cesarean delivery was performed under general anesthesia at 34 weeks. Immediately after awake fiberoptic intubation and induction of general anesthesia, capnography waveform was lost with rapid profound oxygen desaturation. A supraglottic airway device was placed, oxygenation maintained with supraglottic airway and positive pressure ventilation throughout case, and the baby was delivered with Apgars of 8 and 9.
Successful Use of Cangrelor and Heparin for Cardiopulmonary Bypass in a Patient With Heparin-Induced Thrombocytopenia and End-Stage Renal Disease: A Case Report
imageHeparin is the only well-established anticoagulant medication for cardiopulmonary bypass making selecting an alternative anticoagulant challenging in patients with heparin-induced thrombocytopenia. Other anticoagulant medications can cause significant postoperative bleeding, especially in patients with end-stage renal disease. We present a case of a 63-year-old woman requiring aortic valve replacement with a history of heparin-induced thrombocytopenia and end-stage renal disease. Cangrelor and heparin were successfully used during cardiopulmonary bypass, offering an option for anticoagulation management for a uniquely challenging patient population.
Extraluminal Use of a Pediatric Bronchial Blocker With Confirmation by Point-of-Care Ultrasound: A Case Report
imageLung isolation for pediatric thoracic surgery is especially challenging in a patient with chronic lung infection and need to protect the nonoperative lobes from the spread of infection during anesthesia and surgery. Typically, for pediatric thoracic surgery, a mainstem intubation or placement of an intraluminal bronchial blocker is sufficient for lung isolation. The patient whose case is reported here suffered from a pleuropulmonary blastoma compressing the left lower lobe bronchus and resultant chronic infection involving the left lower lobe. In this unusual situation, to isolate the chronic lung infection and to provide the needed adequate operative conditions, endobronchial intubation of the right, nonoperative lung and placement of an endobronchial blocker into the left lower lobe bronchus were performed. Intraoperative point-of-care ultrasound was then used to confirm ventilation of the right lung segments and absence of air movement in the left upper lobe.
Efficacy of Sugammadex in Preventing Skin Test Reaction in a Patient With Confirmed Rocuronium Anaphylaxis: A Case Report
imageThe curative role of sugammadex has been challenged in several observations of rocuronium-induced anaphylaxis because sugammadex may not completely encapsulate the molecule of rocuronium. In such conditions, rocuronium remains able to cause immunoglobulin E cross-linkage and the anaphylaxis mechanism can continue. We describe a case of rocuronium-induced anaphylaxis in which clinical improvement followed sugammadex administration. Intradermic skin tests confirmed rocuronium immunoglobulin E–mediated anaphylaxis but also showed intradermal injection of mixing in equal molecular ratio of sugammadex with rocuronium preventing rocuronium anaphylactic skin reaction. This observation demonstrates the efficacy of sugammadex to prevent rocuronium interaction with the skin immune system.
Nebulized Lidocaine in the Treatment of Refractory Postoperative Laryngospasm: A Case Report
Intraoperative laryngospasm occurs in <1% of cases. Recurrent laryngospasm is rarer. Some risk factors include shared airway and pediatric surgery, secretions, pungent volatile anesthetics, and patient factors, such as smoking and asthma. Conventional management includes the application of positive airway pressure, jaw thrust, the removal of any offending stimuli, deepening anesthesia, or administering muscle relaxants. Nebulized lidocaine is used to anesthetize the vocal cords before awake fiberoptic intubation. This case highlights the novel use of nebulized lidocaine to successfully treat refractory postoperative laryngospasm in a fully conscious adult patient after conventional measures were unsuccessful.
Failed Awake Intubation for Critical Airway Obstruction Rescued With the Ventrain Device and an Arndt Exchange Catheter: A Case Report
imageA 71-year-old man with advanced vocal cord carcinoma presented with severe airway obstruction. Therapeutic anticoagulation with enoxaparin complicated management. Failure of an oral awake bronchoscopic intubation was rescued by passing a guidewire through the working channel and threading an Arndt exchange catheter into the trachea under videoscopic vision. Ventilation with the Ventrain device lasting 40 minutes (15 L/min, inspiration/expiration 1:1, 15 breaths/min), during IV anesthesia with muscle paralysis, resulted in excellent blood gas values until placement of the tracheal cannula. This case report highlights the effectiveness of a novel ventilation technique that should be considered as back-up when bronchoscopic intubation fails.
Localized Corticosteroid Injections for Malignant Joint Pain in the Oncologic Population: A Case Series
imagePain is a common issue that is present in cancer survivors as well as those with active malignant processes. Despite opioid analgesics and adjuvant therapies such as systemic corticosteroids, many patients have persistent localized pain. We describe a case series of 3 cancer patients who have concurrent hip- and greater trochanteric–related pain. We performed a single-insertion-site, ultrasound-guided injection to target both the intra-articular hip and greater trochanteric bursa for each patient. All patients reported an improvement in pain symptoms and function with no major complications. Targeted corticosteroid injections provide a potential for relief of malignant joint pain.
Low-Dose Intrathecal Ziconotide for Spasticity From Primary Lateral Sclerosis: A Case Report
Spasticity can be very debilitating and painful. We present a case of severe spasticity from primary lateral sclerosis refractory to intrathecal baclofen in doses up to 1100 μg/d. Baclofen was weaned down and switched to intrathecal ziconotide at 0.6 μg/d. The dose was then titrated up to 3 μg/d with excellent control of spasticity. This case suggests that low-dose intrathecal ziconotide should be considered in patients with lower extremity spasticity refractory to intrathecal baclofen.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Anaesthesia