Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174


MedWorm: Intensive Care, Phosphate Binders and Transport Inhibitors on FGF-23 in CKD Phosphate…
MedWorm: Intensive Care,Phosphate Binders and Transport Inhibitors on FGF-23 in CKD Phosphate Binders and Transport Inhibitors on FGF-23 in CKDNisha Bansal, MD, reviews the COMBINE trial on nicotinamide and lanthanum carbonate and changes in phosphate and fibroblast growth factor-23 levels in patients with chronic kidney disease.Medscape Nephrology (Source: Medscape Critical Care Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:58


MedWorm: Cancer & Oncology, Study Compares USPSTF, Other Lung Cancer Screening Guidance A…
MedWorm: Cancer & Oncology,Study Compares USPSTF, Other Lung Cancer Screening GuidanceA research letter published June 4 in Annals of Internal Medicine discussed a study that analyzed how new risk thresholds could identify more current/former smokers eligible for lung cancer screening. (Source: AAFP News)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.MedWorm: Cancer & OncologySat Jun 29, 2019 21:07MS…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:57


MedWorm Speech Therapy Blogs, Noisy Restaurants Are More Than Annoying —They ’ re Discriminatory…
MedWorm Speech Therapy Blogs,Noisy Restaurants Are More Than Annoying —They ’ re DiscriminatoryLoud is in when it comes to eating out. The trend of loud restaurants began with design—modern spaces filled with hard surfaces and featuring high ceilings—making voices bounce around the space. Some restaurants purposely amp up the noise level by playing loud music, forcing diners to shout above it. More recently, diners and even food critics are rebelling against the trend by pointing out annoying noise…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:55


MedWorm Palliative Care News, Medical News Today: What to know about end-stage COPD The symptoms…
MedWorm Palliative Care News,Medical News Today: What to know about end-stage COPDThe symptoms of end-stage chronic obstructive pulmonary disease (COPD) include frequent lung infections, difficulty eating, and shortness of breath. Coping methods typically include palliative care and open discussions. Learn more here. (Source: Health News from Medical News Today)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.MedWorm…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:54


MedWorm ENT & OMF Research
Significant Milestones in This Journal’s HistoryLast night I returned from the annual meeting of the Editorial Board of this Journal. As the editor-in-chief, I am humbled by the collection of intellectual talent at this event. Everyone “present” is a busy oral-maxillofacial surgeon (present is in quotation marks because some members were present via telephone conferencing owing to the unusual late April weather in the Rosemont area); yet they all carve out time to help make our Journal an industry…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:53


MedWorm ENT & OMF Research, Precision of orthognathic digital plan transfer using patient-specific…
MedWorm ENT & OMF Research,Precision of orthognathic digital plan transfer using patient-specific cutting guides and osteosynthesis versus mixed analogue –digitally planned surgery: a randomized controlled clinical trialOver the last decade, the accuracy of three-dimensional computer-assisted orthognathic surgery has been investigated extensively. The absence of high-quality controlled trials, limited number of studies overall, and methodological flaws have hindered its use in general clinical…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:52


MedWorm ENT & OMF News, Medical News Today: What causes a bad smell in the nose? Causes of…
MedWorm ENT & OMF News,Medical News Today: What causes a bad smell in the nose?Causes of a bad smell in the nose include sinusitis, mouth or tooth infections, and certain foods and drinks. Learn more about what might cause a bad smell in the nose, and what to do about it, here. (Source: Health News from Medical News Today)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.MedWorm ENT & OMF NewsFri Jun…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:51


MedWorm Cancer & Oncology Research, CXCR4 antagonism in combination with IDO1 inhibition…
MedWorm Cancer & Oncology Research,CXCR4 antagonism in combination with IDO1 inhibition weakens immune suppression and inhibits tumor growth in mouse breast cancer bone metastases(Source: OncoTargets and Therapy)MedWorm Cancer & Oncology ResearchFri Jun 28, 2019 03:20MicroRNA-3662 targets ZEB1 and attenuates the invasion of the highly aggressive melanoma cell line A375(Source: Cancer Management and Research)MedWorm Message: Have you tried our new medical search engine? More powerful than…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:50


MedWorm Cancer & Oncology Research, The Effectiveness of the Sport “Dragon Boat Racing”…
MedWorm Cancer & Oncology Research,The Effectiveness of the Sport “Dragon Boat Racing” in Reducing the Risk of Lymphedema Incidence: An Observational StudyConclusions The dragon boat sport participants had more positive clinical and QoL outcomes than did the women who did not participate in that sporting activity. Implications for Clinical Practice It would be important to make women with breast cancer aware of the practice of dragon boat racing. (Source: Cancer Nursing)MedWorm Message: If you…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:50


MedWorm Cancer & Oncology Research, Fri Jun 28, 2019 17:47 Diagnostic Value of Diffusion…
MedWorm Cancer & Oncology Research,Fri Jun 28, 2019 17:47Diagnostic Value of Diffusion Weighted Magnetic Resonance Imaging in Evaluation of Metastatic Neck Lymph Nodes in Head and Neck Cancer: A Sample of Iranian Patient. CONCLUSION: MR diffusion imaging and ADC values as a non-invasive technique can assess<br />metastatic neck LNs in head and neck cancer with higher sensitivity, specificity and accuracy. PMID: 31244301 [PubMed – in process] (Source: Asian Pacific Journal of Cancer Prevention)Fri…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:48

MedWorm

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:47


MedWorm
MedWorm Allergy & Immunology BlogsFri Jun 28, 2019 17:55Whole Genome Sequencing Heads for Consumers – Rodrigo Martinez of Veritas Genetics Mark above section as readMedWorm Allergy & Immunology Clinical TrialsThu Jun 27, 2019 18:00Personalized Targeted Preparative Regimen Before T-depleted Allogeneic HSCT in Children With Chemoresistent Acute Leukemias Conditions: Refractory Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia Intervention: Drug: Preparative regimen Sponsor:…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:41


The New England Journal of Medicine
NEJM : ResearchApplication of High-Sensitivity Troponin in Suspected Myocardial InfarctionChest pain suggestive of myocardial infarction is a leading cause of presentation to the emergency department worldwide. In addition to the electrocardiogram and clinical symptoms, the serial measurement of cardiac troponin is key in ruling out or diagnosing myocardial infarction. With the…NEJM : ResearchThu Jun 27, 2019 03:00Early Sedation with Dexmedetomidine in Critically Ill PatientsSedation is a component…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:39


JoVE: Journal of Visualized Experiments, The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia…
JoVE: Journal of Visualized Experiments,The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia ManagementThis protocol describes the development process of a digital dyspepsia educational tool. Assessment of unmet needs and literature, content development, and building of the tool are presented. The methodology can be used as a guide for future development of digital educational tools.JoVE: Journal of Visualized ExperimentsSat Jun 29, 2019 21:00Enzymatic Synthesis of Epoxidized Metabolites of…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:37


Journal of Internal Medicine, Subclinical atherosclerosis and its progression are modulated…
Journal of Internal Medicine,Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagyAbstract Background Hyperlipidemia is a major risk factor for cardiovascular disease and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin‐2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective We…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:36


AMB Express – Optimization of whole-cell biotransformation for scale-up production of α-arbutin…
AMB Express – Optimization of whole-cell biotransformation for scale-up production of α-arbutin from hydroquinone by the use of recombinant Escherichia coliα-Arbutin is an effective skin-whitening cosmetic ingredient and hyperpigmentation therapy agent. It can be synthesized by one-step enzymatic glycosylation of hydroquinone (HQ), but limited by the low yield. A…AMB Express – Latest ArticlesFri Jun 28, 2019 03:00Correction to: Development of a novel strategy for fungal transformation based on…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:36


ScienceDirect Publication Trends in Immunology, Self-DNA Sensing in Lung Inflammatory Diseases…
ScienceDirect Publication Trends in Immunology,Self-DNA Sensing in Lung Inflammatory DiseasesPublication date: Available online 28 June 2019Source: Trends in ImmunologyAuthor(s): Sulayman Benmerzoug, Bernhard Ryffel, Dieudonnée Togbe, Valerie F.J. QuesniauxSelf-DNA sensing by the immune system has emerged as a key contributing response in the pathogenesis of cancer and autoimmune diseases. Recent studies have established that release of nuclear and mitochondrial DNA can also drive lung inflammatory…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:36


NeuroImage, The peripheral preview effect with faces: Combined EEG and eye-tracking suggests…
NeuroImage,The peripheral preview effect with faces: Combined EEG and eye-tracking suggests multiple stages of trans-saccadic predictive and non-predictive processingPublication date: Available online 28 June 2019Source: NeuroImageAuthor(s): Christoph Huber-Huber, Antimo Buonocore, Olaf Dimigen, Clayton Hickey, David MelcherAbstractThe world appears stable despite saccadic eye-movements. One possible explanation for this phenomenon is that the visual system predicts upcoming input across saccadic…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:35


Audiology, Communications Service for the Deaf Announces Filmaking Partner Communication Service…
Audiology,Communications Service for the Deaf Announces Filmaking PartnerCommunication Service for the Deaf (CSD) is partnering with Bus Door Films (BDF) as part of its CSD Social Venture Fund. BDF is a deaf-owned early stage creative production and filmmaking business focused on providing video services for both deaf and hearing clients while increasing the deaf talent pool behind the camera. The CSD Social Venture Fund is a social fund and incubator for deaf-owned businesses in the United States….

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:35


Le Scienze > I primi ominidi e la nascita dell’industria litica Il sito di Bokol Dora,…
Le Scienze > I primi ominidi e la nascita dell’industria liticaIl sito di Bokol Dora, in Etiopia, ha restituito pietre scheggiate che risalgono a più di 2,58 milioni di anni fa, epoca in cui sarebbe avvenuta una svolta importante nella …Le Scienze > Rss07:37Quando iniziammo a cuocere tuberi e radiciI nostri antenati avevano l’abitudine di arrostire tuberi e radici già 120.000 anni fa. Lo documenta uno studio archeologico nelle grotte di Klasies River, in Sudafrica, da cui …Le Scienze >…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:34


Factors predicting difficult endotracheal intubation Fri Jun 28, 2019 17:29 by Brit Long, Alex Koyfman,…
Factors predicting difficult endotracheal intubation Fri Jun 28, 2019 17:29by Brit Long, Alex Koyfman, Michael Gottlieb via Wiley: Academic Emergency Medicine: Table of ContentsAbstractEndotracheal intubation is a common procedure in emergency medicine, and recognizing a potentially difficult intubation is imperative in planning for the procedure. While the “can’t intubate, can’t ventilate” scenario is rare, it is catastrophic if the airway operator is not prepared.1‐3 Thus, predicting factors associated…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:33


Molecular Pharmaceutics: Latest Articles (ACS Publications), [ASAP] Co-Delivery of Paclitaxel…
Molecular Pharmaceutics: Latest Articles (ACS Publications),[ASAP] Co-Delivery of Paclitaxel by a Capsaicin Prodrug Micelle Facilitating for Combination Therapy on Breast CancerMolecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00209Molecular Pharmaceutics: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Increasing the Potential of the Auristatin Cancer-Drug Family by Shifting the Conformational EquilibriumMolecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.9b00437Molecular…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:32


Macromolecules: Latest Articles (ACS Publications), [ASAP] Nonlinear Elasticity and Swelling…
Macromolecules: Latest Articles (ACS Publications),[ASAP] Nonlinear Elasticity and Swelling of Comb and Bottlebrush NetworksMacromoleculesDOI: 10.1021/acs.macromol.9b00956Macromolecules: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Dynamics of Critical Clusters Synthesized by End-Coupling of Four-Armed Poly(ethylene glycol)sMacromoleculesDOI: 10.1021/acs.macromol.9b01066Macromolecules: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Full and Partial Amidation of…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:32


The AAPS Journal, Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6…
The AAPS Journal,Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE PathwayAbstract Redox imbalance is a major contributor to the pathogenesis of melanoma and nonmelanoma skin cancer. Activation of the nuclear factor E2–related factor 2 (Nrf2) antioxidant responsive element (ARE) pathway is an intrinsic defense mechanism against oxidative stress. Flavonoids such as anthocyanidins, which are found abundantly in fruits and vegetables,…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:32


3 Biotech, Glucose biosensor based on screen-printed electrode modified with silicone sol–gel…
3 Biotech,Glucose biosensor based on screen-printed electrode modified with silicone sol–gel conducting matrix containing carbon nanotubesAbstract This research shows that high-performance biosensors can be produced by modification of screen-printed electrodes with enzymes and conducting hydrogel based on sol–gel matrix and single-walled carbon nanotubes. Tetraethoxysilane, dimethyldiethoxysilane and polyvinyl alcohol were used as the sol–gel matrix basis. Modified SWCNT provide direct electron…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:31


Journal of Natural Products: Latest Articles (ACS Publications), [ASAP] Ascomylactams A–C,…
Journal of Natural Products: Latest Articles (ACS Publications),[ASAP] Ascomylactams A–C, Cytotoxic 12- or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus <italic toggle="yes">Didymella</italic> sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and CJournal of Natural ProductsDOI: 10.1021/acs.jnatprod.8b00918Journal of Natural Products: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:31


Chemical Research in Toxicology: Latest Articles (ACS Publications), [ASAP] Robust Antibacterial…
Chemical Research in Toxicology: Latest Articles (ACS Publications),[ASAP] Robust Antibacterial Activity of Tungsten Oxide (WO<sub>3-x</sub>) NanodotsChemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.8b00399Chemical Research in Toxicology: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Rotenone Increases Isoniazid Toxicity but Does Not Cause Significant Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:31


Biomacromolecules: Latest Articles (ACS Publications), [ASAP] PHBHHx Facilitated the Residence,…
Biomacromolecules: Latest Articles (ACS Publications),[ASAP] PHBHHx Facilitated the Residence, Survival and Stemness Maintain of Transplanted Neural Stem Cells in Traumatic Brain Injury RatsBiomacromoleculesDOI: 10.1021/acs.biomac.9b00408Biomacromolecules: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Hyaluronic Acid Derivatives for Translational MedicinesBiomacromoleculesDOI: 10.1021/acs.biomac.9b00564Biomacromolecules: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00Mark…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:30


Acta Cirurgica Brasileira, The role of ischemic preconditioning in the expression of apoptosis-related…
Acta Cirurgica Brasileira,The role of ischemic preconditioning in the expression of apoptosis-related genes in a rat model of intestinal ischemia-reperfusion injuryAbstract Purpose: To analyze the effects of ischemic preconditioning (IPC) in the expression of apoptosis-related genes in rat small intestine subjected to ischemia and reperfusion. Methods: Thirty anesthetized rats underwent laparotomy and were drive into five groups: control (CG); ischemia (IG); ischemia and reperfusion (IRG); IPC and…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:30


ACS Synthetic Biology: Latest Articles (ACS Publications), [ASAP] An Engineered <italic…
ACS Synthetic Biology: Latest Articles (ACS Publications),[ASAP] An Engineered <italic toggle="yes">B. subtilis</italic> Inducible Promoter System with over 10?000-Fold Dynamic RangeACS Synthetic BiologyDOI: 10.1021/acssynbio.8b00469ACS Synthetic Biology: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00[ASAP] Metabolic Engineering of the MEP Pathway in <italic toggle="yes">Bacillus subtilis</italic> for Increased Biosynthesis of Menaquinone-7ACS Synthetic BiologyDOI:…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:30

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174


Gene, <em>MiR-126*</em> is a novel functional target of transcription factor SMAD4…
Gene,<em>MiR-126*</em> is a novel functional target of transcription factor SMAD4 in ovarian granulosa cellsPublication date: Available online 30 June 2019Source: GeneAuthor(s): Qiqi Li, Xing Du, Lu Liu, Zengxiang Pan, Shaoxian Cao, Qifa LiAbstractBoth SMAD4 and miR-126* have been proven to be involved in granulosa cell (GC) apoptosis and even follicular atresia, through commonly regulating follicle-stimulating hormone receptor (FSHR), the FSH-specific transmembrane receptor of GCs….

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:25


Environmental Science & Technology Letters: Latest Articles (ACS Publications), [ASAP]…
Environmental Science & Technology Letters: Latest Articles (ACS Publications),[ASAP] Highly Effective Scaling Mitigation in Membrane Distillation Using a Superhydrophobic Membrane with Gas PurgingEnvironmental Science & Technology LettersDOI: 10.1021/acs.estlett.9b00354Environmental Science & Technology Letters: Latest Articles (ACS Publications)Fri Jun 28, 2019 07:00Mark above section as read Environmental Science & Technology: Latest Articles (ACS Publications),[ASAP] Comparative…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:24


Clinical Endocrinology, Clinical Genetic Testing in Endocrinology: Current Concepts and Contemporary…
Clinical Endocrinology,Clinical Genetic Testing in Endocrinology: Current Concepts and Contemporary ChallengesSummary Recent advances in DNA sequencing technology have led to an unprecedented period of disease‐gene discovery offering many new opportunities for genetic testing in the clinical setting. Endocrinology has seen a rapid expansion in the taxonomy of monogenic disorders, which can be detected by an expanding portfolio of genetic tests in both diagnostic and predictive settings. Successful…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:22


The Journal of Emergency Medicine, Long-Term Survival After Drowning-Related Cardiac Arrest Publication…
The Journal of Emergency Medicine,Long-Term Survival After Drowning-Related Cardiac ArrestPublication date: Available online 28 June 2019Source: The Journal of Emergency MedicineAuthor(s): Joshua C. Reynolds, Thomas Hartley, Erica A. Michiels, Linda QuanAbstractBackgroundLong-term outcomes after drowning-related cardiac arrest are not well characterized.ObjectiveOur aims were to estimate long-term survival and identify prognostic factors in a large, population-based cohort of drowning victims with…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:22


Sports Medicine, Do Self-Myofascial Release Devices Release Myofascia? Rolling Mechanisms: A Narrative…
Sports Medicine,Do Self-Myofascial Release Devices Release Myofascia? Rolling Mechanisms: A Narrative ReviewAbstract The term “self-myofascial release” is ubiquitous in the rehabilitation and training literature and purports that the use of foam rollers and other similar devices release myofascial constrictions accumulated from scar tissue, ischaemia-induced muscle spasms and other pathologies. Myofascial tone can be modulated with rollers by changes in thixotropic properties, blood flow, and fascial…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:21


Annals of Intensive Care – Latest Articles, Translational gap in pediatric septic shock management:…
Annals of Intensive Care – Latest Articles,Translational gap in pediatric septic shock management: an ESPNIC perspectiveThe Surviving Sepsis Campaign and the American College of Critical Care Medicine guidelines have provided recommendations for the management of pediatric septic shock patients. We conducted a survey among the …Annals of Intensive Care – Latest ArticlesFri Jun 28, 2019 03:00

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:21


Journal of Cancer Education, The Knowledge, Attitude, and Self-Reported Behaviors of Oncology…
Journal of Cancer Education,The Knowledge, Attitude, and Self-Reported Behaviors of Oncology Physicians Regarding Fertility Preservation in Adult Cancer PatientsAbstract There is a growing concern about the fertility preservation for adult cancer patients of reproductive age. Very little literature exists about fertility preservation of cancer survivors in Chinese text. This study is first to describe the knowledge level, attitude, and practice behaviors among physicians concerning fertility preservation…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:21


Contemporary Clinical Trials, Editorial Board Publication date: July 2019Source: Contemporary…
Contemporary Clinical Trials,Editorial BoardPublication date: July 2019Source: Contemporary Clinical Trials, Volume 82Author(s):ScienceDirect Publication: Contemporary Clinical TrialsSat Jun 29, 2019 17:19Optimal two-stage designs for exploratory basket trialsPublication date: Available online 29 June 2019Source: Contemporary Clinical TrialsAuthor(s): Heng Zhou, Fang Liu, Cai Iris Wu, Eric H. Rubin, Vincent L. Giranda, Cong ChenAbstractThe primary goal of an exploratory oncology clinical trial is…

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12:20


Recent Clinical Trials, Graphical Abstracts Latest Issue of Reviews on Recent Clinical Trials…
Recent Clinical Trials,Graphical AbstractsLatest Issue of Reviews on Recent Clinical Trials06:33Meet Our Regional EditorLatest Issue of Reviews on Recent Clinical Trials06:33Research on the Development of Collaterals from Occluded Internal Mammary Arteries and Refractory Angina: Where are we in 2019?Latest Issue of Reviews on Recent Clinical Trials06:33Psychosocial Risk Factors and Ischemic Heart Disease: A New PerspectiveLatest Issue of Reviews on Recent Clinical Trials06:33Risk Factors for Ischemic…

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12:19


New Clinical Trials, Non-Hodgkin’s Lymphoma – Durham NC MTem Non-Hodgkin’s Lymphoma StudyHAVE…
New Clinical Trials,Non-Hodgkin’s Lymphoma – Durham NCMTem Non-Hodgkin’s Lymphoma StudyHAVE YOU BEEN DIAGNOSED WITH NON-HODGKIN’S LYMPHOMA? We are now seeking volunteers to participate in a clinical study of a potential new treatment for Non-Hodgkin’s Lymphoma.YOU OR A LOVED ONE MAY QUALIFY IF YOU: Are 18 years of age or older Have been diagnosed with Non-Hodgkin’s Lymphoma Have had at least one tumor screened by CT or MRI Do not have any current infections or wounds Have not been diagnosed with…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:19


Clinical Trials News, Pfizer Announces Results from Phase 3 Trial of Revatio® (Sildenafil Citrate)…
Clinical Trials News,Pfizer Announces Results from Phase 3 Trial of Revatio® (Sildenafil Citrate) in Newborns with Persistent Pulmonary HypertensionNEW YORK–(BUSINESS WIRE)–Pfizer Inc. (NYSE: PFE) announced today that a Phase 3 study to assess the efficacy and safety of intravenous (IV) sildenafil when added to inhaled nitric oxide (iNO) for the treatment of newborns with Persistent Pulmonary Hypertension (PPHN) did not meet its primary efficacy endpoint. Treatment with IV sildenafil when added…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:16


Australasian Journal of Dermatology, Disseminated cutaneous‐only histoplasmosis in a patient…
Australasian Journal of Dermatology,Disseminated cutaneous‐only histoplasmosis in a patient with AIDSAbstract Histoplasmosis is an opportunistic fungal infection that occurs predominantly in immunocompromised patients. Cutaneous lesions in histoplasmosis are rare and typically occur in the absence of extra‐cutaneous manifestations. We present a rare case of disseminated cutaneous‐only histoplasmosis in a patient with recently diagnosed AIDS.Australasian Journal of DermatologyFri Jun 28, 2019 12:13Mark…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:16


British Journal of Oral and Maxillofacial Surgery, Cleft and craniofacial surgery training:…
British Journal of Oral and Maxillofacial Surgery,Cleft and craniofacial surgery training: is it time for a new solution for UK trainees?Publication date: Available online 28 June 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Shofiq IslamBritish Journal of Oral and Maxillofacial SurgeryFri Jun 28, 2019 18:28Quantification of the inaccuracy of conventional articulator model surgery in Le Fort 1 osteotomy: evaluation of 30 patients controlled by the Orthopilot<sup>®</sup>…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:15


Clinical Cases, A Disturbing Decline, Foreword. In this Journal feature, information about a…
Clinical Cases,A Disturbing Decline,Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 29-year-old woman…Clinical CasesThu Jun 06, 2019 03:00

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:14


Journal of Infection and Chemotherapy, <em>Candida auris</em>: A pathogen difficult…
Journal of Infection and Chemotherapy,<em>Candida auris</em>: A pathogen difficult to identify, treat, and eradicate and its characteristics in Japanese strainsPublication date: Available online 28 June 2019Source: Journal of Infection and ChemotherapyAuthor(s): S. Iguchi, Y. Itakura, A. Yoshida, K. Kamada, R. Mizushima, Y. Arai, Y. Uzawa, K. KikuchiAbstractCandida auris is a multidrug-resistant and emergent pathogen that has caused healthcare-associated infection outbreaks. Recently,…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:14


Pigment Cell & Melanoma Research, Loss‐of‐function mutations in the melanocortin‐1‐receptor…
Pigment Cell & Melanoma Research,Loss‐of‐function mutations in the melanocortin‐1‐receptor (Mc1r) cause disruption of dorso‐ventral countershading in teleost fishAbstract The Melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes. Additionally, in mammals MC1R is the main receptor for agouti signaling protein (ASIP), making it the critical receptor for the establishment of…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:13


Cells, Cells, Vol. 8, Pages 658: The Lymphatic Headmaster of the Mast Cell-Related Splanchnic…
Cells,Cells, Vol. 8, Pages 658: The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal HypertensionCells, Vol. 8, Pages 658: The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension Cells doi: 10.3390/cells8070658 Authors: Aller M.A. Blanco-Rivero J. Arias N. Santamaria L. Arias J. Portal hypertension is a common complication of liver disease, either acute or chronic. Consequently, in chronic liver disease, such as the hypertensive…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:13


Clinical Cases, Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart Transplantation…
Clinical Cases,Case 20-2019: A 52-Year-Old Woman with Fever and Rash after Heart TransplantationPresentation of Case. Dr. Taylor A. Lebeis: A 52-year-old woman who had undergone orthotopic heart transplantation because of dilated cardiomyopathy was admitted to this hospital with painful red lesions on the left arm and leg. Eight years before this admission, the patient had ongoing episodes of…Clinical CasesThu Jun 27, 2019 03:00Case 19-2019: A 38-Year-Old Woman with Abdominal Pain and FeverPresentation…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:12


New Scientist – Picture of the day, We could kill cancer cells by hijacking their odd electrical…
New Scientist – Picture of the day,We could kill cancer cells by hijacking their odd electrical currentA recently discovered bioelectrical current could be turned against itself to switch off and kill cancer cellsNew Scientist – Picture of the day10:00How palaeontology got cool: Inside the revolution in dinosaur scienceDinosaurs have won a huge following as new techniques revolutionise what we know about how they lived and even looked. How well are popular books keeping up?New Scientist – Picture…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:12


Brain – Functional neurological disorder: an ethical turning point for neuroscience This scientific…
Brain – Functional neurological disorder: an ethical turning point for neuroscienceThis scientific commentary refers to ‘The prognosis of functional limb weakness: a 14-year case-control study’, by Gelauff et al. (doi:10.1093/brain/awy138).Brain – current issueWed Jun 26, 2019 03:00Freezing of gait in Parkinson’s disease reflects a sudden derangement of locomotor network dynamicsAbstractFreezing of gait is a disabling symptom of Parkinson’s disease that causes a paroxysmal inability to generate…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:11


Medical News Today, Medical News Today: Letter from the Editor: It’s good to laugh In this month’s…
Medical News Today,Medical News Today: Letter from the Editor: It’s good to laughIn this month’s letter, Managing Editor Honor reveals what the MNT editorial team got up to for their annual summer event, and it might just make you chuckle.Featured Health News from Medical News TodaySat Jun 29, 2019 18:00Medical News Today: How childhood viral infections may later drive multiple sclerosisBased on a study in mice, researchers now suggest that transient viral infections in childhood may facilitate multiple…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:10


Health – Google News, World’s first anti-HIV gel enters trial phase – Daily Nation World’s first…
Health – Google News,World’s first anti-HIV gel enters trial phase – Daily NationWorld’s first anti-HIV gel enters trial phase Daily NationWorld’s first anti-HIV gel enters trial phase nation.co.keView full coverage on Google NewsHealth – Google News09:19Baroness Blackwood faints in House of Lords – BBC NewsBaroness Blackwood faints in House of Lords BBC NewsThe 39-year-old peer, who suffers from a rare genetic condition, says it was "no big deal".Health – Google NewsSat Jun 29, 2019 23:27One…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:09


Mental health | The Guardian, War’s trauma endures long after the last shot is fired – broken…
Mental health | The Guardian,War’s trauma endures long after the last shot is fired – broken souls need rebuildingThe world provides food and tents when wars end, yet neglects the mental scars. It is a flawed response to deep sufferingThe genocide in Rwanda a quarter of a century ago claimed the lives of many hundreds of thousands of people. They were killed, over the course of just 100 days, simply for who they were. Afterwards, the international community provided food, water and tents. Countries…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:08


International Journal of Molecular Sciences, IJMS, Vol. 20, Pages 3218: Trifluoperazine, an Antipsychotic…
International Journal of Molecular Sciences,IJMS, Vol. 20, Pages 3218: Trifluoperazine, an Antipsychotic Drug, Effectively Reduces Drug Resistance in Cisplatin-Resistant Urothelial Carcinoma Cells via Suppressing Bcl-xL: An In Vitro and In Vivo StudyIJMS, Vol. 20, Pages 3218: Trifluoperazine, an Antipsychotic Drug, Effectively Reduces Drug Resistance in Cisplatin-Resistant Urothelial Carcinoma Cells via Suppressing Bcl-xL: An In Vitro and In Vivo Study International Journal of Molecular Sciences…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:08


International Journal for Numerical Methods in Biomedical Engineering, A computational model…
International Journal for Numerical Methods in Biomedical Engineering,A computational model of open‐irrigated radiofrequency catheter ablation accounting for mechanical properties of the cardiac tissueAbstract Radiofrequency catheter ablation (RFCA) is an effective treatment for cardiac arrhythmias. Although generally safe, it is not completely exempt from the risk of complications. The great flexibility of computational models can be a major asset in optimizing interventional strategies, if they…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:07


Onmed – Έξι φρούτα που μπορεί να τρώει η έγκυος το καλοκαίρι (vid) Φρούτα που μπορεί να τρώει…
Onmed – Έξι φρούτα που μπορεί να τρώει η έγκυος το καλοκαίρι (vid)Φρούτα που μπορεί να τρώει η εγκυμονούσα τους καλοκαιρινούς μήνες.Onmed RSS Feed12:00Βρεγμένα μαλλιά: 5 σοβαρά λάθη που πρέπει να αποφεύγετε (εικόνες)Μπορεί η ενυδάτωση να αποτελεί ένα σημαντικό ζήτημα που αφορά στην υγεία μας.Onmed RSS Feed10:00Πώς να προστατέψετε τα νύχια σας από τον ήλιοΜέχρι τώρα γνωρίζατε ότι το δέρμα σας χρειάζεται επαρκή προστασία από την υπεριώδη ακτινοβολία, η οποία όχι μόνο μπορεί να προκαλέσει καρκίνο του…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:06


HealthyLiving.gr, Διαβήτης: Η μείωση της χοληστερόλης μπορεί να επιδεινώσει τα νεύρα Η μείωση…
HealthyLiving.gr,Διαβήτης: Η μείωση της χοληστερόλης μπορεί να επιδεινώσει τα νεύραΗ μείωση των επιπέδων χοληστερόλης του αίματος σε ασθενείς με διαβήτη τύπου 2 σχετίζεται με τη διαβητική νευροπάθεια, σύμφωνα με μελέτη που δημοσιεύτηκε στο JAMA Network Open. Ο Johann Jende, από το Πανεπιστημιακό Νοσοκομείο της Χαϊδελβέργης στη Γερμανία, και οι συνεργάτες του αξιολόγησαν τη σχέση μεταξύ των επιπέδων της χοληστερόλης στο αίμα και των βλαβών των περιφερικών νεύρων σε ασθενείς με διαβήτη τύπου 2. Κάποιοι…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:06


CBC | Health News, Employers should have to foot the bill for mandatory sick notes Doctors…
CBC | Health News,Employers should have to foot the bill for mandatory sick notesDoctors send invoices to insurance companies or lawyers all the time for things not covered by provincial health care plans. This would be no different.CBC | Health News11:00American caravan arrives in Canadian ‘birthplace of insulin’ for cheaper medicineA self-declared "caravan" of Americans bused across the Canada-U.S. border on Saturday, seeking affordable prices for insulin and raising awareness of "the insulin…

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12:05

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3 Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174


BMJ, Online First, Reducing door-to-needle times in stroke thrombolysis to 13 min through protocol…
BMJ, Online First,Reducing door-to-needle times in stroke thrombolysis to 13 min through protocol revision and simulation training: a quality improvement project in a Norwegian stroke centreBackgroundIn eligible patients with acute ischaemic stroke, rapid revascularisation is crucial for good outcome. At our treatment centre, we had achieved and sustained a median door-to-needle time of under 30 min. We hypothesised that further improvement could be achieved through implementing a revised treatment…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:00


Latest headlines from BMJ, Doctors’ pensions: no trust in this government Mahase reports that…
Latest headlines from BMJ,Doctors’ pensions: no trust in this governmentMahase reports that doctors will be able to halve pension contributions to ease tax burden.1 I won’t hold my breath. A consultation will start at the end of June. Meanwhile, many doctors are worried…Latest headlines from BMJFri Jun 28, 2019 18:36NHS to change GP registration rules in response to growth of digital providersDigital first GP providers such as Babylon’s GP at Hand should have to establish a physical location and…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

12:00


BMJ Current issue, A focused mapping review and synthesis of a priori risk factors associated…
BMJ Current issue,A focused mapping review and synthesis of a priori risk factors associated with medical misconductBackgroundMedical misconduct is an international problem. It is judged according to whether a doctor has endangered the health of the public. Little is known about the risk factors associated with medical misconduct. To inform patient safety, we undertook a focused mapping review and synthesis (FMRS) of tribunal reports retrieved from the Medical Practitioners Tribunal Service (MPTS)….

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:59


BMJ Open Current Issue, Research priorities in regional anaesthesia education and training: an…
BMJ Open Current Issue,Research priorities in regional anaesthesia education and training: an international Delphi consensus surveyObjectivesEducation in regional anaesthesia covers several complex and diverse areas, from theoretical aspects to procedural skills, professional behaviours, simulation, curriculum design and assessment. The objectives of this study were to summarise these topics and to prioritise these topics in order of research importance. DesignElectronic structured Delphi questionnaire…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:59


BMJ Case Reports Last 6 Issues, Ischaemic stroke as the initial manifestation of systemic amyloidosis…
BMJ Case Reports Last 6 Issues,Ischaemic stroke as the initial manifestation of systemic amyloidosisA previously healthy 54-year-old woman was admitted to the stroke unit with an acute ischaemic stroke attributed to atrial fibrillation newly diagnosed at the emergency room. Nevertheless, preliminary investigation on stroke aetiology revealed incidental hypoalbuminaemia in the context of nephrotic syndrome, while clinically, the patient developed progressive signs of cardiac failure raising the suspicion…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:58


BMC Research Notes, Gait screening of a population of young, healthy athletes by means of a…
BMC Research Notes,Gait screening of a population of young, healthy athletes by means of a portable, low-cost device unveils hidden left–right asymmetries in both quadriceps and anterior cruciate ligament forcesThe present study reports the on-field screening of a population of young soccer players in the pursuit of alterations in gait using a portable and low-cost gait analysis system composed of a Wii Balance Board…BMC Research NotesFri Jun 28, 2019 03:00Low dietary diversity and its influencing…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:58


International Journal of Radiation Oncology*Biology*Physics, Determining the “Organ-at-Risk”…
International Journal of Radiation Oncology*Biology*Physics,Determining the “Organ-at-Risk” for Lymphedema Following Regional Nodal Irradiation in Breast CancerPublication date: Available online 28 June 2019Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jeffrey P. Gross, Connor M. Lynch, Anne Marie Flores, Sumanas W. Jordan, Irene B. Helenowski, Mahesh Gopalakrishnan, Dan Cutright, Eric D. Donnelly, Jonathan B. StraussAbstractPurposeLymphedema following regional nodal…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:57


Medical Image Analysis, Hierarchical Spherical Deformation for Cortical Surface Registration…
Medical Image Analysis,Hierarchical Spherical Deformation for Cortical Surface RegistrationPublication date: Available online 29 June 2019Source: Medical Image AnalysisAuthor(s): Ilwoo Lyu, Hakmook Kang, Neil D. Woodward, Martin A. Styner, Bennett A. LandmanAbstractWe present hierarchical spherical deformation for a group-wise shape correspondence to address template selection bias and to minimize registration distortion. In this work, we aim at a continuous and smooth deformation field to guide…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:57


Medgadget, Protein-Loaded Antimicrobial Hydrogel to Treat, Prevent Bone Infections Bone infections…
Medgadget,Protein-Loaded Antimicrobial Hydrogel to Treat, Prevent Bone InfectionsBone infections are quite common following orthopedic surgery or as a result of injury or disease. They can be incredibly difficult to treat, and heavy duty antibiotic regimens coupled with debridement surgery is the current approach. Even after all that, inflammation is a frequent side effect. Now, researchers at Georgia Tech have created a hydrogel material that can be used to treat bone infections and even prevent…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:57


Clinical Chemistry and Laboratory Medicine (CCLM), Correlations between serum and CSF pNfH levels…
Clinical Chemistry and Laboratory Medicine (CCLM),Correlations between serum and CSF pNfH levels in ALS, FTD and controls: a comparison of three analytical approachesJournal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of printClinical Chemistry and Laboratory Medicine (CCLM)Fri Jun 28, 2019 15:56Mark above section as read Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)Colorimetric detection of Ba2+, Cd2+…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:56


Antioxidants, Antioxidants, Vol. 8, Pages 202: Dietary Flavonoids for Immunoregulation and Cancer:…
Antioxidants,Antioxidants, Vol. 8, Pages 202: Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting DiseaseAntioxidants, Vol. 8, Pages 202: Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease Antioxidants doi: 10.3390/antiox8070202 Authors: Ahn-Jarvis Parihar Doseff Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative, antioxidant, anti-inflammatory,…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:55


Allergology International, A case of anaphylaxis due to fish collagen in a gummy candy Publication…
Allergology International,A case of anaphylaxis due to fish collagen in a gummy candyPublication date: Available online 28 June 2019Source: Allergology InternationalAuthor(s): Namiko Abe, Tomonobu Ito, Tomoko Kobayashi, Chizu Egusa, Tatsuo Maeda, Yukari Okubo, Ryoji TsuboiAllergology InternationalSat Jun 29, 2019 18:04γδ T cells enhance TSLP production and ILC2 accumulation in house dust mite-induced allergic airway inflammationPublication date: Available online 28 June 2019Source: Allergology InternationalAuthor(s):…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:55


Annals of Diagnostic Pathology, BK virus histopathologic disease severity does not predict allograft…
Annals of Diagnostic Pathology,BK virus histopathologic disease severity does not predict allograft outcome in renal transplant recipientsPublication date: Available online 27 June 2019Source: Annals of Diagnostic PathologyAuthor(s): M. Lee Sanders, Melissa Swee, Mony Fraer, Sarat Kuppachi, Patrick Ten Eyck, Prerna RastogiAbstractAimsBK polyomavirus nephropathy (BKPyVN) is an important cause of allograft failure after renal transplantation. Despite early screening for the virus, allograft loss from…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:54


Anaesthesia Food, fads, allergies and anaphylaxis with propofol Anaesthesia Fri Jun 28,…
AnaesthesiaFood, fads, allergies and anaphylaxis with propofolAnaesthesiaFri Jun 28, 2019 19:38Mark above section as read BMC Anesthesiology – Latest ArticlesContinuous Adductor Canal Block used for postoperative pain relief after medial Unicondylar Knee Arthroplasty: a randomized, double-blind, placebo-controlled trialPeripheral nerve block and local infiltration analgesia (LIA) provide good analgesia after knee replacement. This study evaluated the additional analgesic efficacy of continuous adductor…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:54


Journal of Plastic, Reconstructive & Aesthetic Surgery Preserved Nipple Erectile Function…
Journal of Plastic, Reconstructive & Aesthetic SurgeryPreserved Nipple Erectile Function after Free Nipple Areolar Complex TransplantationIt is generally believed that sensory innervation and preservation of nipple erectile function are lost after free nipple areolar complex (NAC) transplantation. We, however, would like to present a case that already reported ‘restored’ nipple erectile function two weeks after free NAC transplantation following bilateral mastectomy and breast free flap reconstruction…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:53

Synthese
The feeling of grip: novelty, error dynamics, and the predictive brainAbstractAccording to the free energy principle biological agents resist a tendency to disorder in their interactions with a dynamically changing environment by keeping themselves in sensory and physiological states that are expected given their embodiment and the niche they inhabit (Friston in Nat Rev Neurosci 11(2):127–138, 2010. doi:10.1038/nrn2787). Why would a biological agent that aims at minimising uncertainty in its encounters…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:42

Immunopathology
Inflammation and type 2 diabetes: from basic science to treatmentTreatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patientsAbstractWith obesity and type 2 diabetes prevalence steadily increasing and no effective means in sight to support the population in obtaining and maintaining stable weight loss, there is an imminent need for pharmacological therapy to treat and prevent type 2 diabetes. Current anti-diabetic treatment is symptomatic, and very few drugs have both…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:42

Diabetology
Clinical impact of sarcopenia and dynapenia on diabetesAbstractSarcopenia as a progressive and generalized skeletal muscle disorder that is associated with an increased likelihood of adverse outcomes, including falls, fractures, physical disability, and mortality. On the other hand, an age-related decline in muscle strength prior to the reduction of muscle mass, is proposed to be "dynapenia". Sarcopenia and dynapenia have recently been recognized as a diabetic complications in type 2 diabetes. We…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:41

Molecular Histology
Tamarixetin protects against cardiac hypertrophy via inhibiting NFAT and AKT pathwayAbstractCardiac hypertrophy is a compensatory response in reaction to mechanical load that reduces wall stress by increasing wall thickness. Chronic hypertrophic remodeling involves cardiac dysfunction that will lead to heart failure and ultimately death. Studies have been carried out on cardiac hypertrophy for years, whereas the mechanisms have not been well defined. Tamarixetin (TAM), a natural flavonoid derivative…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:40

Sophia
Problems with Compensation: Gleeson on Marilyn McCord Adams on EvilAbstractAccording to the most recent articulation of her view, Marilyn Adams’s reply to the problem of horrendous evils states that God offers compensation to those who experience horrendous evils. This compensation includes the good of the incarnation of God and the good of identification with God in virtue of suffering horrendous evils. Andrew Gleeson has raised a series of objections to Adams’s recent articulation. I argue that…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:40

DGNeurologie
Die Rubrik „Im Fokus"Tiefe Hirnstimulation des Kleinhirns reduziert die Ataxie bei der shaker -RatteVorsicht bei der Vernichtung von PatientenunterlagenIntrathekale Nusinersentherapie bei Erwachsenen mit spinaler MuskelatrophieAkinetisch-rigide Bewegungsstörungen unter AntikonvulsivaMagazinNeuromyelitis-optica-Spektrum-ErkrankungFacharzt für NeurologieErster epileptischer AnfallZusammenfassungZiel der Diagnostik nach einem ersten Anfallsereignis ist zunächst die ätiologische Einordnung, ob ein epileptischer…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:39

Designs, Codes and Cryptography
Correction to: Improved Singleton bound on frequency hopping sequences and optimal constructionsThe original version of this article unfortunately contained a mistake in an equation.Polynomial time bounded distance decoding near Minkowski’s bound in discrete logarithm latticesAbstractWe propose a concrete family of dense lattices of arbitrary dimension n in which the lattice bounded distance decoding (BDD) problem can be solved in deterministic polynomial time. This construction is directly adapted…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:39

Stochastic Environmental Research and Risk Assessment
Spatial prediction of landslide susceptibility in Taleghan basin, IranAbstractIdentifying landslide-susceptible zones is warranted to prevent and mitigate associated hazards in mountainous regions, where a landslide is a destructive type of erosion. A landslide susceptibility map was developed for the Taleghan basin based on frequency ratio (FR), logistic regression (LR), maximum entropy (MaxEnt), and support vector machine (SVM) with radial base (RBF), sigmoid (SIG), linear (LN), and polynomial…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:38

Biogerontology
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditionsAbstractNicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a gradual diminution in physiological functions in an organism over time, leading to development of age-associated pathologies and eventually increasing the probability…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:37

Gastroenterology
Serological screening for coeliac disease in patients with juvenile idiopathic arthritisPublication date: Available online 7 June 2019Source: Arab Journal of GastroenterologyAuthor(s): Yasin Sahin, Sezgin Sahin, Kenan Barut, Fugen Cullu Cokugras, Tulay Erkan, Amra Adrovic, Tufan Kutlu, Ozgur KasapcopurAbstractBackground and study aimsJuvenile idiopathic arthritis (JIA) is characterized by autoimmune aetiology. A gene locus 4q27 related to rheumatoid arthritis, psoriatic arthritis, and coeliac disease…

medicine-sfakianakis-alexandros.blogspot.com?w=16&cs=1433717846&v=3

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:36

Cancer Education
The Knowledge, Attitude, and Self-Reported Behaviors of Oncology Physicians Regarding Fertility Preservation in Adult Cancer PatientsAbstractThere is a growing concern about the fertility preservation for adult cancer patients of reproductive age. Very little literature exists about fertility preservation of cancer survivors in Chinese text. This study is first to describe the knowledge level, attitude, and practice behaviors among physicians concerning fertility preservation in adult cancer patients…

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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174

11:35

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

Stochastic Environmental Research and Risk Assessment

Spatial prediction of landslide susceptibility in Taleghan basin, Iran

Abstract

Identifying landslide-susceptible zones is warranted to prevent and mitigate associated hazards in mountainous regions, where a landslide is a destructive type of erosion. A landslide susceptibility map was developed for the Taleghan basin based on frequency ratio (FR), logistic regression (LR), maximum entropy (MaxEnt), and support vector machine (SVM) with radial base (RBF), sigmoid (SIG), linear (LN), and polynomial (PL) kernel functions. To this end, an inventory map with 166 landslide locations was prepared and partitioned into 70% and 30% to train and validate the models, respectively. Subsequently, the models were designed based on 13 factors including elevation, slope degree, slope aspect, distance to stream, Stream Power Index, Topographic Wetness Index, Stream Transport Index, distance to fault, lithology, soil texture, land use, distance to road and precipitation. The performance of the methods was assessed using the area under the receiver operating characteristic curve, the Seed Cell Area Index (SCAI), the precision index (P). Moreover, statistical measures including sensitivity, specificity, and accuracy were calculated. Friedman test was also applied to confirm significant statistical differences among the seven models employed in this research. The validation results showed that MaxEnt had the maximum area under the curve (0.812). The results obtained using the models LR, FR, PL-SVM, SIG-SVM, LN-SVM, and RBF-SVM were 0.807, 0.732, 0.679, 0.663, 0.643 and 0.660, respectively. The obtained P index showed the better performance of MaxEnt and LR models. Moreover, the trend of changes in the SCAI values, from low- to high-susceptibility, indicated that the MaxEnt and LR models had the best performance. Decision makers can effectively use the findings of the present study to mitigate the financial and human costs resulting from the landslides.

One-dimensional solute transport in open channel flow from a stochastic systematic perspective

Abstract

Solute transport by river and stream flows in natural environment has significant implication on water quality and the transport process is full of uncertainties. In this study, a stochastic one-dimensional solute transport model under uncertain open-channel flow conditions is developed. The proposed solute transport model is developed by upscaling the stochastic partial differential equations through their one-to-one correspondence to the nonlocal Lagrangian–Eulerian Fokker–Planck equations. The resulting Fokker–Planck equation is a linear and deterministic differential equation, and this equation can provide a comprehensive probabilistic description of the spatiotemporal evolutionary probability distribution of the underlying solute transport process by one single numerical realization, rather than requiring thousands of simulations in the Monte Carlo simulation. Consequently, the ensemble behavior of the solute transport process can also be obtained based on the probability distribution. To illustrate the capabilities of the proposed stochastic solute transport model, various steady and unsteady uncertain flow conditions are applied. The Monte Carlo simulation with stochastic Saint–Venant flow and solute transport model is used to provide the stochastic flow field for the solute transport process, and further to validate the numerical solute transport results provided by the derived Fokker–Planck equations. The comparison of the numerical results by the Monte Carlo simulation and the Fokker–Planck equation approach indicated that the proposed model can adequately characterize the ensemble behavior of the solute transport process under uncertain flow conditions via the evolutionary probability distribution in space and time of the transport process.

Compound effects of rainfall and storm tides on coastal flooding risk

Abstract

Rainfall and storm tides are both flood drivers in coastal zones. The complex interplay between them can lead to or exacerbate the impacts of flooding. While the dependence between rainfall and storm tides has been extensively studied, the compound effects of them on coastal flood risk have not been well researched. With Haikou city as the case study, this study investigates the bivariate return period of compounding rainfall and storm tide events based on copula functions and the failure probability is used to assess the variation of bivariate flood risk during the entire project lifetime. The results show that (1) there is a significant correlation between rainfall and storm tides. Therefore, bivariate RP analysis can provide more adequate and comprehensive information about risks than univariate RP analysis. Kendall RP can describe the bivariate RP more accurately since the dangerous region of Kendall RP is divided by the joint probability value. (2) Neglecting the compounding impacts and the dependence of rainfall and storm tides causes significant underestimation of the joint RP and failure probability. (3) The bivariate hydrologic risk value will decrease quickly when the design rainfall is higher than 100 mm and it becomes small and decrease slowly when the design rainfall exceeds 450 mm. Furthermore, the bivariate hydrologic risk value would not decrease until the storm tide is higher than 2 m and the values would become quite small as the storm tide exceeds 4.5 m. Such bivariate hydrologic risk analysis can provide decision support for hydraulic facility design as well as actual flood control and mitigation.

Toward parsimonious modeling of frequency of areal runoff from heavy-to-extreme precipitation in large urban areas under changing conditions: a derived moment approach

Abstract

Translating changes in land surface conditions and climate into changes in precipitation, runoff and flood frequencies over a range of catchment scales is a pressing challenge for hydrologic design and flood risk management today. In this paper, we describe a novel approach for modeling areal runoff frequency from heavy-to-extreme precipitation in large urban areas using a simple but general stochastic model for runoff at point scale and bi- and univariate parametric probability distributions for positive point precipitation and areal runoff, respectively. We apply the approach to the Dallas–Fort Worth area using a 22-year historical multisensor precipitation dataset from the National Weather Service to characterize how the different factors that specify the second-order statistics of precipitation, imperviousness and soil water holding capacity at point scale may shape areal runoff frequency, and to assess how changes in precipitation climatology and land surface conditions may change areal runoff frequency as a function of catchment scale and magnitude of precipitation. The results indicate that areal runoff frequency is impacted most significantly by changes in climatological mean and coefficient of variation of positive point precipitation, water holding capacity of soil, imperviousness, and spatial correlation scale of positive point precipitation given the probability of occurrence of heavy-to-extreme precipitation, and that a very small number of low-order statistics of point precipitation may describe areal runoff frequency given the conditional probability distribution models for point precipitation and areal runoff. The approach presented hence offers a parsimonious physically-based alternative to purely numerical approaches based on integrated modeling, or empirical approaches based solely on statistical modeling toward predictive modeling of areal precipitation and runoff frequencies under changing hydroclimatological conditions.

Hydrological post-processing based on approximate Bayesian computation (ABC)

Abstract

This study introduces a method to quantify the conditional predictive uncertainty in hydrological post-processing contexts when it is cumbersome to calculate the likelihood (intractable likelihood). Sometimes, it can be difficult to calculate the likelihood itself in hydrological modelling, specially working with complex models or with ungauged catchments. Therefore, we propose the ABC post-processor that exchanges the requirement of calculating the likelihood function by the use of some sufficient summary statistics and synthetic datasets. The aim is to show that the conditional predictive distribution is qualitatively similar produced by the exact predictive (MCMC post-processor) or the approximate predictive (ABC post-processor). We also use MCMC post-processor as a benchmark to make results more comparable with the proposed method. We test the ABC post-processor in two scenarios: (1) the Aipe catchment with tropical climate and a spatially-lumped hydrological model (Colombia) and (2) the Oria catchment with oceanic climate and a spatially-distributed hydrological model (Spain). The main finding of the study is that the approximate (ABC post-processor) conditional predictive uncertainty is almost equivalent to the exact predictive (MCMC post-processor) in both scenarios.

Retraction Note to: Adaptive neuro-fuzzy evaluation of wind farm power production as function of wind speed and direction
The Editor-in-Chief has retracted this article (Petković et al. 2015a) because validity of the content of this article cannot be verified.
Expression of Concern: Adaptation of ANFIS model to assess thermal comfort of an urban square in moderate and dry climate
The Editor-in-Chief of Stochastic Environmental Research and Risk Assessment is issuing an editorial expression of concern for article.
Expression of Concern: Potential of adaptive neuro-fuzzy inference system for evaluation of drought indices
The Editor-in-Chief of Stochastic Environmental Research and Risk Assessment is issuing an editorial expression of concern to alert readers that this article (Gocić et al. 2015) shows substantial indication of irregularities in authorship during the submission process.
Retraction Note to: Support vector regression methodology for prediction of output energy in rice production
The Editor-in-Chief has retracted this article [1] because validity of the content of this article cannot be verified. This article showed evidence of peer review and authorship manipulation. The authors do not agree to this retraction.
Forecasting salinity time series using RF and ELM approaches coupled with decomposition techniques

Abstract

Using historical salinity data from nine drought periods in the Pearl River Delta of China, this study utilized two machine learning approaches to forecast the salinity time series for multistep lead times: random forest (RF) models and extreme learning machine (ELM) models. To improve conventional RF and ELM models, three signal decomposition techniques were applied to preprocess the input time series: empirical mode decomposition (EMD), wavelet decomposition (WD) and wavelet packet decomposition (WPD). The study results indicated that in contrast to conventional RF/ELM, a hybrid RF/ELM method accompanied by decomposition techniques displayed better forecasting performance and yielded reasonably accurate prediction results. More specifically, hybrid models coupled with WPD displayed the best performance for all three forecast lead times of one, three and five days, whereas EMD underperformed both WPD and WD because of the limited predictability of the components. Both the WPD and WD hybrid models using the \(coif5\) wavelet basis performed better than those using the other two bases (db8 and sym8). In addition, ELM method performed better for conventional and WD/WPD hybrid models, whereas the RF method worked better for EMD hybrid model. The findings of the study showed that the nonstationary salinity series could be transformed into several relatively stationary components in the decomposition process, which provided more accurate salinity forecasts. The developed hybrid models coupling RF/ELM method with decomposition techniques could be a feasible way for salinity prediction.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Stochastic Environmental Research and Risk Assessment

Biogerontology

Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions

Abstract

Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a gradual diminution in physiological functions in an organism over time, leading to development of age-associated pathologies and eventually increasing the probability of death. Ischemia is the lack of nutritive blood flow that causes damage and mortality that mostly occurs in various organs during aging. During the process of aging and related ischemic conditions, NAD+ levels decline and lead to nuclear and mitochondrial dysfunctions, resulting in age-related pathologies. The majority of studies have shown that restoring of NAD+ using supplementation with intermediates such as nicotinamide mononucleotide and nicotinamide riboside can be a valuable strategy for recovery of ischemic injury and age-associated defects. This review summarizes the molecular mechanisms responsible for the reduction in NAD+ levels during ischemic disorders and aging, as well as a particular focus is given to the recent progress in the understanding of NAD+ precursor’s effects on aging and ischemia.

Oxidative stress resistance as a factor in aging: evidence from an extended longevity phenotype of Drosophila melanogaster

Abstract

Longevity of a species is a multifactorial quantitative trait influenced by genetic background, sex, age and environment of the organism. Extended longevity phenotypes (ELP) from experimental evolution in the laboratory can be used as model systems to investigate the mechanisms underlying aging and senescence. ELPs of Drosophila are correlated with various life history attributes such as resistance to environmental stressors (starvation, desiccation, cold and paraquat), developmental time, biochemical defenses, etc. The association between oxidative stress resistance and longevity is not clear and ELPs offer an opportunity to examine the role of oxidative stress resistance in longevity. Here, we have investigated the hypothesis that enhanced oxidative stress resistance and elevated antioxidant defense system play a positive role in longevity using an ELP of Drosophila melanogaster. An ELP of D. melanogaster isolated and characterized in our laboratory through artificial selection (inbred laboratory strain of Oregon K) is employed in this study. Our ELP, named as long lifespan (LLS) flies, shows marked extension in lifespan when compared to the progenitor population (normal lifespan, NLS) and makes a suitable model to study the role of mitochondrial genome in longevity because of its least heterogeneity. In this study, sensitivity to ethanol with age was employed as a measure of resistance to oxidative stress in NLS and LLS flies. Effect of age and oxidative stress on longevity was examined by employing NLS and LLS flies of different age groups against ethanol-induced oxidative stress. Results show that the lower mortality against ethanol was associated with enhanced oxidative stress resistance, higher antioxidant defenses, lower reactive oxygen species (ROS) levels, enhanced alcohol dehydrogenase activity and better locomotor ability attributes of LLS flies. In addition, age-related changes like locomotor impairments, decreased antioxidant defenses, higher ROS levels and sensitivity to oxidative stress were delayed in LLS flies when compared to NLS. Our study supports the hypothesis that higher oxidative stress resistance and enhanced antioxidant defenses are significant factors in extending longevity.

N -Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression

Abstract

N-Acetylcysteine (NAc) has been shown to play a diversity of favorable health-related roles (e.g., antioxidant, paracetamol antidote, mucolytics, neuroprotective agent). Having said that, here in this study, we evaluate the health-promoting properties of NAc, particularly its ability to modulate organismal longevity. We note that 1 mg/ml NAc prolonged the lifespan of Drosophila. Furthermore, it was observed that NAc increased the capability of these flies to resist environmental stresses measured by starvation and paraquat stress assays. In an effort to reveal cellular mechanisms behind this interesting phenomenon, qPCR was performed, uncovering that transcript levels of catalase and phospholipid hydroperoxide glutathione peroxidase—key enzymes to fend off reactive oxygen species (ROS) assaults, were up-regulated. Correspondingly, enzyme activities of catalase and glutathione peroxidase were increased as well. Combined, we hope our research helps broaden the spectrum of clinical application for NAc so that one may eventually determine if NAc is a potentially useful anti-aging agent by encouraging others to scrutinize the hidden health benefits of NAc.

Administration of rGDF11 retards the aging process in male mice via action of anti-oxidant system

Abstract

One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Current studies have generated disputes on the effects of GDF11 and GDF8, a closely related member of GDF11, on rejuvenation and anti-aging properties. In this study, we first demonstrated that when recombinant GDF8 (rGDF8) and GDF11 (rGDF11) of the fish Nothobranchius guentheri were injected into 20-month-old male mice, their serum GDF8 and GDF11 levels were clearly increased. We also showed that injection of rGDF8 and rGDF11 had little influences on the body weight and serological parameters of the mice, indicating their general condition and physiology were not affected. Based on these findings, we started to test the effects of administration of piscine rGDF11 and rGDF8 on the aging process of male mice and to explore the underlying mechanisms. It was found that rGDF11 was able to reduce the levels of AGEs, protein oxidation and lipid peroxidation, and to slow down the accumulation of age-related histological markers, while rGDF8 was not. Moreover, rGDF11 significantly prevented the decrease in CAT, GPX and SOD activities, but rGDF8 did not. Collectively, these results suggest that it is GDF11 but not GDF8 that can exert rejuvenation and anti-aging activities via the action of antioxidant system. It is also the first report that shows the activity of GDF11 is not species-specific, implicating potential usefulness of piscine GDF11 in prolonging the lifespan of the elderly.

Fecundity for free? Enhanced oviposition in longevous populations of Drosophila melanogaster

Abstract

Artificial selection for increased life span in experimental populations of Drosophila melanogaster sometimes produces long-lived populations that exhibit greater fecundity than unselected controls. The absence of a trade-off between survival and reproduction in these cases might be an artefact of the rich diet of typical lab culture; if nutritional resources are not limiting then there may be no need to trade off. Here I test the rich diet hypothesis by estimating genetic correlations between survival and age-specific fecundity in three nutritional environments. Experimental material consists of 58 recombinant inbred lines derived from an artificial selection experiment. Reducing the yeast content of medium causes substantial reductions in fecundity but does not alter patterns of genetic correlation. The correlation between life span and early fecundity is non-significant in all environments, while the life span correlations with mid-life fecundity are positive and statistically significant in all environments. The rich diet hypothesis is rejected. Qualitative features of fecundity trajectories are conserved across environments, with long-lived lines exhibiting a secondary peak of oviposition in mid-life. The micro-evolution of extended life span is not a monolithic process and does not necessarily involve direct trade-offs between survival and reproduction.

Toxin-induced hormesis may restrain aging

Abstract

Mild environmental stress might have beneficial effects in aging by activating maintenance and repair processes in cells and organs. These beneficial stress effects fit to the concept of hormesis. Prominent stressors acting in a hormetic way are physical exercises, fasting, cold and heat. This review will introduce some toxins, which have been found to induce hormetic responses in animal models of aging research. To highlight the molecular signature of these hormetic effects we will depict signaling pathways affected by low doses of toxins on cellular and organismic level. As prominent examples for signaling pathways involved in both aging processes as well as toxin responses, PI3K/Akt/mTOR- and AMPK-signal transduction will be described in more detail. Due to the striking overlap of signaling pathways mediating toxin induced responses and aging processes we propose considering the ability of low doses of toxins to slow down the rate of aging.

Aging renders desynchronization between clock and immune genes in male Wistar rat kidney: chronobiotic role of curcumin

Abstract

Suprachiasmatic nucleus (SCN) contains the central clock that orchestrate circadian rhythms in physiology and behavior in mammals. Tightly interlocked transcriptional and translational feedback loops (TTFLs) comprising of various clock genes such as Clock, Bmal1, Periods, Cryptochromes etc. in the SCN, send the timing signals to peripheral clocks that governs local metabolism with similar TTFLs. Peripheral clocks in kidney regulates several circadian rhythms like blood pressure, immunity etc. However, aging leads to circadian and inflammatory disorders in kidney. Though there are increasing evidences on age associated perturbations, studies elucidating the rhythmic expression of clock and immune genes across aging in kidney are obscure. We therefore studied changes in daily rhythms of clock and immune genes in kidney. In this study we measured mRNA expression of clock genes rBmal1, rPer1, rPer2, rCry1, rCry2, rReverbα, rRorα, and inflammatory genes rNfκb1, rTnfα, rIl6, rTlr4 and rTlr9 in 3, 12 and 24 months male Wistar rat kidney using qRT-PCR. From our study, we did not observe significant changes in clock genes expression except rRorα, but immune genes showed significant phase alterations as well as increase in mean 24 h levels. Pearson correlation analysis of data showed desynchronization between immune and clock genes expression. We further studied the effect of administration of curcumin which has anti-aging, anti-inflammatory, anti-oxidant etc. properties, and evaluated its chronobiotic properties. We here report differential effects of curcumin administration on daily rhythms of clock and immune genes expression.

Submandibular gland-specific inflammaging-induced hyposalivation in the male senescence-accelerated mouse prone -1 line (SAM-P1)

Abstract

Aging has pronounced effects on mammalian tissues and cells, but the impacts of aging on salivary gland function are relatively unknown. This study aims to evaluate the effects of aging on submandibular gland (SMG) and parotid gland (PG) functions in the male senescence-accelerated mouse. In vivo analysis at the systemic level revealed that salivary secretion induced by pilocarpine, a muscarinic agonist, from the SMG was significantly decreased in aged mice, whereas salivary secretion from the PG was not affected. To evaluate organ-level function, the SMG was perfused with the muscarinic agonists carbachol and calcium ionophore A23187 ex vivo to induce salivary secretion, and decreased saliva production was also observed in the aged SMG. Histological analysis revealed the presence of CD4-positive lymphocytes infiltrating the aged SMG. Furthermore, real-time PCR revealed that the aged SMG exhibited accelerated cell aging, increased levels of the inflammatory cytokine interleukin-6, and decreased mRNA levels of the water channel protein aquaporin-5 (AQP5). In summary, these results demonstrate that SMG function in aged mice was diminished, and that cell senescence, chronic inflammation, and the decreased gene expression of AQP5 are the likely causes of hyposalivation in the SMG of aged mice.

Activation of transposable elements and genetic instability during long-term culture of the human fungal pathogen Candida albicans

Abstract

It has been repeatedly reported that transposable elements (TE) become active and/or mobile in the genomes of replicatively and stress-induced senescent mammalian cells. However, the biological role of senescence-associated transposon activation and its occurrence and relevance in other eukaryotic cells remain to be elucidated. In the present study, Candida albicans, a prevalent opportunistic fungal pathogen in humans, was used to analyze changes in gene copy number of selected TE, namely Cirt2, Moa and Cmut1 during long-term culture (up to 90 days). The effects of stress stimuli (fluconazole, hydrogen peroxide, hypochlorite) and ploidy state (haploid, diploid, tetraploid cells) were also considered. An increase in copy number of Cirt2 and Moa was the most accented in tetraploid cells after 90 days of culture that was accompanied by changes in karyotype patterns and slightly more limited growth rate compared to haploid and diploid cells. Stress stimuli did not potentiate TE activity. Elevation in chromosomal DNA breaks was also observed during long-term culture of cells of different ploidy, however this was not correlated with increased TE activity. Our results suggest that increased TE activity may promote genomic diversity and plasticity, and cellular heterogeneity during long-term culture of C. albicans cells.

Therapeutic effects of curcumin on age-induced alterations in daily rhythms of clock genes and Sirt1 expression in the SCN of male Wistar rats

Abstract

The aging brain is linked to accumulation of oxidative stress and increase in damage to biomolecules which in turn may cause or promote circadian dysfunction by disruption of biological clock, the suprachiasmatic nucleus (SCN). Age associated alterations in clock gene expression in the SCN has been reported earlier. In the present study we have examined therapeutic effects of the antioxidant curcumin on age induced alterations in daily rhythms and levels of core clock genes in SCN of young [3 months (m)], middle (12 months) and old (24 months) male Wistar rats. Curcumin was administered orally at ZT-11, 1 hour (h) before the onset of darkness. The effect of curcumin administration on daily rhythms and levels of expression of clock genes such as rBmal1, rPer1, rPer2, rCry1, rCry2 and rReverbα as well as on the clock modulator rSirt1 were studied. There was restoration of phase of rPer1, rPer2, rCry1, rCry2 and daily pulse of rPer2 in middle aged animals. However, in old aged rats the phase and daily pulse of rPer1 were restored with curcumin treatment. rSirt1 did not show age related alterations in its transcript levels though the rhythms were abolished in old aged rat SCN. Pearson correlation analysis showed that curcumin administration to 12 and 24 months animals had resulted in restorations of several correlations among clock genes which were found to be altered/abolished in age matched control groups. In addition, strong interlocking interactions between rSirt1 and clock genes were observed in young age which were disrupted with aging and curcumin administration resulted in partial restoration.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Biogerontology

Gastroenterology

Serological screening for coeliac disease in patients with juvenile idiopathic arthritis
Publication date: Available online 7 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Yasin Sahin, Sezgin Sahin, Kenan Barut, Fugen Cullu Cokugras, Tulay Erkan, Amra Adrovic, Tufan Kutlu, Ozgur Kasapcopur

Abstract
Background and study aims

Juvenile idiopathic arthritis (JIA) is characterized by autoimmune aetiology. A gene locus 4q27 related to rheumatoid arthritis, psoriatic arthritis, and coeliac disease is associated with susceptibility to JIA. There are reports indicating several patients with JIA had been diagnosed with CD. We aimed to assess the frequency of coeliac disease (CD) in patients with juvenile idiopathic arthritis (JIA).

Patients and methods

This prospective study was carried out from October 2015 to August 2016 and included 96 patients with JIA. All patients were evaluated in terms of clinical and laboratory findings of CD. Levels of total IgA and tissue transglutaminase antibody (tTG) IgA were measured in all patients. Those with increased level of tTG IgA were further tested for anti-endomysium IgA antibodies (EMA). Gastroduodenoscopy were planned for a definite diagnosis of CD in patients with positive EMA.

Results

Of the 96 patients in our study, 34 (35.4%) had oligoarticular form of JIA, 29 (30.2%) had polyarticular form, 12 (12.5%) had ERA form, 11 (11.5%) had systemic form, and 10 (10.4%) had psoriatic form. Sixteen of our patients (16.6%) were not using any drugs during the study. Neither EMA IgA antibodies were analysed nor gastro-duodenoscopy was performed because no patients were positive for tTG IgA. There was no difference in terms of tTG levels between the patients using NSAIDs or other drugs.

Conclusion

We did not find CD in children with JIA. Long term studies with more JIA patients are needed to provide more precise interpretation.

Six-minute walk test before and after large-volume paracentesis in cirrhotic patients with refractory ascites: A pilot study
Publication date: Available online 7 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Nahed A. Makhlouf, Zainab Gaber Mahran, Samiaa Hamdy Sadek, Doaa M. Magdy, Hoda A. Makhlouf

Abstract
Background/Aims

Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among cirrhotic patients with refractory ascites before and after large-volume paracentesis. The research aim was to assess the feasibility of performing the 6MWT among cirrhotic patients who had refractory ascites before and after large-volume paracentesis.

Materials and Methods

Thirty-one cirrhotic inpatients with refractory ascites were subjected to pulmonary function tests (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], FEV1/FVC) and diffusion lung capacity for carbon monoxide (DLCO) before and 48 h after therapeutic large-volume paracentesis. Dyspnoea as assessed by the Borg scale and functional capacity as assessed by the 6MWT were also evaluated.

Results

Prior to paracentesis, the mean values of FVC and FEV1 were lower than the predicted values, and a significant increase was observed after paracentesis. There was improvement in the mean DLCO values after paracentesis (P < 0.05). Regarding the 6MWT, significant increases in the walked distance (6MWD) (310.7 ± 73 vs. 348.7 ± 72.3 m) and oxygen saturation after paracentesis (P = 0.001) were observed. Significant improvement in the dyspnoea scale also occurred after paracentesis (P = 0.001). A significant positive correlation between the 6MWD before paracentesis and serum albumin levels was demonstrated (r = 0.373, P = 0.039).

Conclusion

We found a decrease in pulmonary function and the 6MWD in patients who had refractory ascites, which improved significantly following large-volume paracentesis. The 6MWT is useful in detecting impaired functional capacity among cirrhotic patients.

Endoscopic ultrasound-guided fine needle aspiration in diagnosis of cystic pancreatic lesions
Publication date: Available online 7 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Hussein Okasha, Mervat E. Behiry, Nagwa Ramadan, Reem Ezzat, Ahmed Yamany, Shaimaa El-Kholi, Ghada Ahmed

Abstract
Background and study aims

pancreatic cysts are commonly found lesions and proper diagnosis is very important for planning further management. The study aims to evaluate the role of cyst fluid amylase and tumour markers as cancer antigen (CA 19-9) and carcinoembryonic antigen (CEA) in addition to mucin stain in diagnosing pancreatic cysts and differentiating malignant from benign lesions.

Patients and methods

This prospective study was conducted on 184 patients diagnosed to have pancreatic cystic lesions from January 2013 to January 2018. Fluid analysis for CA 19-9, CEA, amylase, mucin stain and cytopathology were done. We compared these data with the final diagnosis based on histopathology after surgical resection, positive cytopathology and long period of follow up of the patients for at least 18 months.

Results

The highest AUC was that of cystic CEA with cut-off value of 160 ng/ml; it had a sensitivity of 60.4% and a specificity of 85%. The best cut-off value for cystic CA 19-9 was 1318 U/ml with a sensitivity of 64.1% and a specificity of 68.1%. The cut-off value of cyst amylase level was 5500 U/L, with 84.2% sensitivity and 37.1% specificity. The sensitivity of mucin stain in detecting mucinous cystic neoplasm was 85.45%, specificity was 86.05% with accuracy 85.87%.

Conclusion

Cyst fluid analysis by investigating amylase, mucin, CA 19-9, CEA and EUS examination improves the diagnosis of different pancreatic cysts.

Clinical presentation and outcomes of acute diverticulitis in a Middle Eastern population
Publication date: Available online 4 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Jasim Alabbad, Fawaz Abdul Raheem, Saba Al-Saddah, Abdulaziz Al-Mubarak

Abstract
Background and study aims

There is lack of literature describing the presentation of diverticulitis in the Middle East population. The aim of this study is to provide an analysis of the epidemiological indicators, patterns of presentation and outcomes of acute diverticulitis in a Middle Eastern population.

Patients and methods

A retrospective review of all adult patients over the age of 17 who were admitted to the surgical service with a diagnosis of acute diverticulitis between January 2010 and May 2018 at a major university affiliated government hospital in the state of Kuwait. Data collected included patients’ demographics, clinical presentation, management and outcome.

Results

Between January 2010 and May 2018 there were 132 patients admitted with a diagnosis of acute diverticulitis. The mean age was 49.2 [±14.3] years. There were 89 (67.4%) men and 43 (32.6%) women. One-hundred and fifteen patients (87.1%) were Arabs, of which Kuwaiti citizens represented 58.3%. Most patients (76.5%) presented with uncomplicated diverticulitis. One hundred and twelve patients (84.8%) had sigmoid colon diverticulitis. There were nine patients that were readmitted within thirty days. The mean length of hospital stay was 5.3 days [±4.5]. The median follow-up period was 15.6 weeks (IQR 1.8, 118.4), during which time recurrent attacks occurred in 25 patients (18.9%).

Conclusions

It appears that there is a low prevalence of acute diverticulitis in Arabs living in Kuwait, and that when they do present with acute diverticulitis the majority present at a relatively younger age with uncomplicated disease.

Duodenal lymphocytosis in functional dyspepsia
Publication date: Available online 4 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Annalisa Capannolo, Stefano Necozione, Dolores Gabrieli, Fabiana Ciccone, Laura Sollima, Loredana Melchiorri, Angelo Viscido, Giuseppe Frieri

Abstract
Background and study aims

Functional dyspepsia is an exclusion diagnosis requiring different tests, including endoscopy, often repeated over time. Duodenal biopsies are frequently resorted to, not rarely revealing duodenal microscopic inflammation. Aim of the study is to confirm a previously supposed role of antro-duodenal low-grade inflammation in functional dyspepsia, evaluating the frequency of duodenal lymphocytosis, H. pylori infection and their association in a group of patients with functional dyspepsia compared to asymptomatic control subjects.

Patients and methods

A cross-sectional, observational study has been conducted screening all the patients who underwent duodenal biopsies during upper endoscopy, in a 30 months period. All the patients without endoscopic lesions were analysed. The study group consisted of patients compatible with the diagnosis of functional dyspepsia (Rome III criteria). The control group consisted of healthy asymptomatic subjects in the population subjected to endoscopy. The presence of duodenal lymphocytosis and of H. pylori infection in the two groups was evaluated.

Results

216 patients were enrolled: 161 in the functional dyspepsia group and 55 as asymptomatic control group. The frequency of duodenal lymphocytosis was similar between cases and control groups (25.47% vs 25.45%; p = 0.99), as well as H. pylori infection (26.71% vs 23.64%; p = 0.78). Duodenal lymphocytosis was significantly associated with functional dyspepsia only in H. pylori positive dyspeptic patients (p = 0.047). 94% of the subjects with both lymphocytosis and H. pylori infection suffer from dyspepsia. Duodenal intraepithelial lymphocytosis is significantly associated with bloating (p = 0.0082).

Conclusions

In our cohort of dyspeptic patients, duodenal lymphocytosis is significantly associated with bloating and the simultaneous presence of duodenal lymphocytosis and H. pylori infection is significantly more prevalent than in control subjects.

Egyptian liver library: An indexed database for liver disease evidence in Egypt
Publication date: Available online 4 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Mohamed Alboraie, Naglaa Youssef, Ahmed F Sherief, Shimaa Afify, Mohamed-Naguib Wifi, Dalia Omran, Enas Hafez, Heba Omar, Mohamed Eltabbakh, Mohamed Abdellah, Mohamed El Badry, Mohamed Salaheldin, Yasmeen Ahmed, Zainab Ali-Eldin, Amir Farid, Nermeen Abdeen, Hesham El Halwagy, Mohammad Abdalgaber, Inas Moaz, Sameera Ezzat

Abstract

Liver diseases are among the most challenging health care problems worldwide. In Egypt, we established different care programs to combat liver diseases including schistosomiasis and viral hepatitides. A lot of research work addressing liver diseases in Egypt have been published with special focus on these two major fields. Other liver disease seems to be neglected although present and contributing to the liver disease burden in Egypt. In this report we reviewed the available evidence published from Egypt and elucidate areas of weakness and future research needs. Our search for Egyptian liver disease evidence retrieved 4683 articles, 67% of them were relevant to the topic. Out of the relevant articles; 1646/3265 (50.4%) were discussing clinical science, 1131 (34.7%) were discussing basic science and 488 (14.9%) were discussing both basic and clinical sciences. Cairo university (16.8%, n = 513) and Mansoura university (9.3%, n = 285) had the largest number of publications related to liver disease in Egypt respectively. The most commonly reported diseases were hepatitis C in 719/3361 articles (21.4%), parasitic liver infestations in 663 articles (19.7%), hepatocellular carcinoma in 544 articles (16.2%), liver fibrosis or cirrhosis in 537 articles (16%), and drug induced liver injury in 516 articles (15.4%). Most of the reviewed articles (36%) were discussing treatment of chronic liver diseases (n = 1201) followed by diagnostics (28%, n = 940), pathogenesis and pathophysiology (21%, n = 706). This review will direct attention to areas with less research like hepatitis B related liver disease, HIV/HCV co-infections, and non-alcoholic fatty liver disease (NAFLD) to encourage future research in these topics. In conclusion; our results ring a bell inviting the development of a roadmap for liver research in Egypt targeting to put future policies to cover areas of weakness in liver research with an ultimate goal of tackling liver disease and its overwhelming socioeconomic burden in our developing country.

Conversion to EUS-guided internal gallbladder drainage from percutaneous cholecystostomy: A successful case using a novel plastic stent
Publication date: Available online 4 June 2019

Source: Arab Journal of Gastroenterology

Author(s): Yuki Hayashi, Kosuke Minaga, Tomoe Yoshikawa, Tatsuya Ishii, Hisakazu Matsumoto, Yoshito Uenoyama, Yukitaka Yamashita

Abstract

For acute cholecystitis with high surgical risk, endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) has shown high clinical and technical success rates. Dilation of the punctured fistula is a technically challenging aspect of EUS-GBD. Over-dilation makes stent insertion easier; however, it increases the risk of bile leakage. Currently, the endoscopic devices available for EUS-GBD are limited, which presents device-related shortcomings. When the stent cannot pass through the dilated fistula, the deployment of a conventional double-pigtail plastic stent requires discarding of the stent and re-puncturing of the gallbladder. Recently, a novel integral double-pigtail plastic stent tied with a pusher catheter that allows the stent to be pulled back on insertion failure was developed. Here, we describe a patient in whom EUS-GBD was successfully performed using this novel stent that enables adjustment during dilation, making EUS-GBD safer.

High prevalence of obesity among infants presenting with intussusception: Findings in an Egyptian cohort
Publication date: Available online 30 May 2019

Source: Arab Journal of Gastroenterology

Author(s): Khaled Ashour, Mona Nada, Mai Ebidy, Gehad Eladely, Ahmed Elabany, Omneya M. Omar

Abstract
Background and study aims

Intussusception is a life-threatening illness, with incompletely understood aetiology, although some predisposing factors are known. Intussusception frequently occurs in well-nourished chubby infants. We aimed to determine whether patients presenting with intussusception have a high prevalence of obesity.

Patients and methods

This cross sectional study was conducted in 100 infants presenting with intussusception aged ≤2 years at the Paediatric Surgery Department. Anthropometric measures, history of recent upper respiratory tract infection, timing and type of intervention were recorded. A near median split divided the population into younger (aged < 8 months, N = 47) and older (8–24 months, N = 53) groups. Obesity was defined as having a body weight for length ≥ 97.7th centile on WHO growth charts.

Results

The study comprised 58 boys and 42 girls, 31% of whom had upper respiratory infection in the preceding month. Obesity was present in 18% of patients, based on WHO growth charts. There was a trend towards higher percentage of obese infants within the younger (25%) compared to older age groups (12%, P = 0.085), but no gender difference. Obesity did not influence the rate of success of hydrostatic reduction. Based on Egypt-specific growth charts, the percentage of infants with a weight-for-age centile ≥ 85th was 42%, of whom 7% were ≥ 97.7th centile. The corresponding percentages for the weight-for-length were 29% and 15% of patients respectively.

Conclusion

There is a high prevalence of obesity in infants presenting with intussusception, particularly under 8 months of age. The mechanistic link between obesity and the pathogenesis of intussusception deserves investigation.

Diagnostic and prognostic value of serum IL-23 in colorectal cancer
Publication date: Available online 30 May 2019

Source: Arab Journal of Gastroenterology

Author(s): Dina F. Elessawi, Manal M. Alkady, Iman M. Ibrahim

Abstract
Background and study aims

Cytokines play a pivotal role in the induction of host immune responses against tumour growth and are involved in the development and progression of colorectal cancer in humans. The role of IL-23 in colorectal cancer is still unclear. Thus, we aimed to determine IL-23 levels in the development and progression of colorectal (CRC) cancer.

Patients and methods

Thirty two patients with colorectal cancer aged 60.4 ± 3.5 years. and 20 age, sex and BMI ‑matched healthy control subjects were included in the study. Serum IL-23 levels were determined using enzyme linked immunosorbent assay. C-reactive protein (CRP) levels were determined using a turbidimetric immunoassay. Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) were measured by radioimmunoassay.

Results

IL-23 levels were found significantly higher in patients relative to the control subjects (p < 0.001) and were gradually increased with TNM tumour stage progression. The mean CRP, CEA and CA-19-9 levels also were significantly higher in patients (p < 0.001). There was a significant correlation between the serum levels of IL-23 and the other measured parameters in CRC patients. The area under receiver operating characteristic curve (ROC) for serum IL-23 was 0.955 at cut off value ≥57.15 with sensitivity 96% and specificity 100%.

Conclusion

The observed results suggest that IL-23 may have a potential role in the pathogenesis and progression of colorectal malignancy and may be a good marker of colorectal cancer and stage progression.

Covered metal stent placement followed by EUS-guided choledochoduodenostomy for balloon-assisted ERCP-induced duodenal perforation
Publication date: Available online 29 May 2019

Source: Arab Journal of Gastroenterology

Author(s): Min Jae Yang, Jin Hong Kim, Jae Chul Hwang, Byung Moo Yoo

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Gastroenterology

Cancer Education

The Knowledge, Attitude, and Self-Reported Behaviors of Oncology Physicians Regarding Fertility Preservation in Adult Cancer Patients

Abstract

There is a growing concern about the fertility preservation for adult cancer patients of reproductive age. Very little literature exists about fertility preservation of cancer survivors in Chinese text. This study is first to describe the knowledge level, attitude, and practice behaviors among physicians concerning fertility preservation in adult cancer patients in China. A cross-sectional survey with 30-item was conducted to assess Chinese oncology physicians’ knowledge, attitude, and behaviors regarding fertility issues. Of 360 oncology physicians, 206 (57.2%) submitted valid questionnaires. With possible overall scores for knowledge and attitude of 9 and 15, respectively, physicians’ responses to the questionnaires were 3.91 ± 1.67 and 12.29 ± 1.23. Only 49.5% of physicians routinely informed their cancer patients of childbearing age about the risk of infertility with cancer treatment. The knowledge score of the men physicians was 2-fold that of the women. Physicians aged 20–29 years were significantly more likely than other age groups to prioritize cancer treatment over fertility concerns. Men physicians were significantly more comfortable than the women discussing fertility preservation issues and cooperating with fertility specialists. The oncology physicians in China had limited knowledge of fertility preservation and rarely discussed these issues with their patients, although their attitude was positive. Results suggest that oncology physicians would welcome an in-house fertility-related training program.

Key Messages

This is the first study to address the topic of fertility preservation as it relates to the care that oncologists provide to cancer patients in China. These results revealed the importance of providing fertility-related training program to oncology physicians. Moreover, this study should provide useful information for other Asian countries, and highlight both the similarities and differences between China and Western countries concerning the reproductive rights of patients. This study should encourage international cooperation with institutions of scientific research and education.

My Kaleidoscope Life: Interconnected Roles as Teacher, Researcher, and Cancer Survivor

Abstract

Surviving cancer dramatically alters one’s perception of the world. “My Kaleidoscope Life” reflects on the interconnected roles as teacher, researcher, and cancer survivor. It provides a personal narrative and perspective on the challenges, successes, and lessons learned from having cancer. It emphasizes how surviving cancer can shift priorities, connect with others, and enhance the quality of life.

Low-Intensity Resistance Training and Compression Garment in the Management of Breast Cancer–Related Lymphedema: Single-Blinded Randomized Controlled Trial

Abstract

There is limited evidence regarding the combined effect of exercise and compression garment on breast cancer–related lymphedema (BCRL). Therefore, we investigate the effect of low-intensity resistance training alone or in combination with a compression garment on lymphedema volume, self-reported lymphedema symptoms, and shoulder mobility and function. A total of 60 women with unilateral BCRL were randomly assigned to low-intensity resistance exercises (Rex group, n = 30) or exercises and compression garment (Rex-Com-group, n = 30). Both groups take part in exercises program consisted of 10–12 repetitions at 50 to 60% of one repetition maximum (IRM), three times weekly, for 8 weeks. The primary outcome was lymphedema volume determined by percentage reduction of excess limb volume (ELV). Secondary outcomes were lymphedema symptoms (pain, heaviness, and tightness) and shoulder mobility and function using the disabilities of the arm, shoulder, and hand (DASH) questionnaire. All measurements were standardized and performed before (week 0, W0), after the intervention (week 8, W8), and at follow-up (week 12, W12). A significant reduction in percentage of ELV (p < 0.01), pain severity (p < 0.05), a sensation of heaviness (p < 0.05) and tightness (p < 0.001), and improvement in shoulder range of motion (p < 0.05) and function on DASH scores (p < 0.05) were observed at W8 and W12 in both groups. However, no between-group differences were observed over time. These findings suggest that low-intensity resistance training, irrespective of garment use, can effectively reduce limb volume and lymphedema symptoms, and increase shoulder mobility and function.

Attitudes Towards Research During Residency Training: a Survey of Canadian Radiation Oncology Residents and Program Directors

Abstract

Radiation oncologists require clinical appraisal and research methodology skills, yet it is unclear how to develop these competencies during residency. We sought to attain a deeper understanding of the barriers that limit, as well as the factors that promote, engaging in research/scholarly activity during radiation oncology residency training in Canada. Following ethics approval, online surveys were circulated to all Canadian Radiation Oncology program directors and residents. Unidentifiable demographics, prior research experience, and descriptions of current research environment and barriers to engaging in research and scholarly activities were collected. Thirty-three percent (35/105) of residents and 71% (10/14) of program directors responded. Ninety-seven percent of residents, and 90% of program directors, agreed or strongly agreed that research/scholarly activity was an important part of residency training. While 66% of residents felt that there was a lack of protected time for research/scholarly activity, only 20% of program directors agreed this was a barrier (p = 0.011). While 94% of residents thought mentorship was important to completing high-quality research/scholarly activity, only 48% of respondents had a mentor. The highest barriers to completing research/scholarly activity projects were lack of protected time (for both residents and faculty), high resident clinical workload, and lack of experience in research skills. Canadian Radiation Oncology residents expressed strong enthusiasm to participate in research/scholarly activity, yet lack of protected time and competing demands were identified as major barriers. We suggest programs offer more protected time for research/scholarly activity, provide optional research methodology training, and support meaningful mentorship relationships.

Psychometric Properties of the MICRA Questionnaire in Portuguese Individuals Carrying SDHx Mutations

Abstract

This study aims to present the translation and cultural adaptation, as well as the psychometric characteristics of the Portuguese version of the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire in individuals with SDHx mutations. The questionnaire was translated and culturally adapted in accordance with the process recommended by the World Health Organization. As per suggestion of the authors of the original instrument, a joint, universal European and Brazilian Portuguese version of the MICRA was created. Ninety-six (asymptomatic or affected) patients with SDHx mutations nationwide completed the adapted version of the MICRA in Portugal. Analyses consisted of confirmatory factor analysis, reliability estimation (alphas), and correlations with two other distress and quality of life instruments. The Portuguese adaptation of the MICRA was understandable to patients from various socioeconomic backgrounds. All items and factor structure of the original version were retained, yielding a good model fit. The MICRA’s three subscales and total score showed good internal consistency, and the correlations found between the Portuguese version of the MICRA and the other instruments assessing similar constructs further supported its validity. The adapted version of the MICRA showed good psychometric properties with a representative population of SDHx mutation carriers. This instrument can now be used to study the multidimensional impact of taking a genetic test for these mutations. It can also be used in future studies with other Portuguese populations of patients submitted to genetic tests for cancer risk assessment.

The Mouse Mammary Gland: a Tool to Inform Adolescents About Environmental Causes of Breast Cancer

Abstract

Adolescence is a vulnerable period of breast development, and environmental chemical exposures that occur during this period can increase the risk of breast cancer in adulthood. Discussing breast health with adolescent girls can be difficult for several reasons. In this project, we worked to not only inform adolescent researchers about environmental risks for breast cancer but to also involve them in research studies. We taught adolescents about the stages of mammary gland development using samples collected from mice, with a specific focus on pre-pubertal and pubertal stages of development. Our analysis shows that adolescent researchers, with relatively modest training, can collect reliable and reproducible data on aspects of mammary gland biology that are known to be disrupted by environmental chemicals, with coefficients of variation < 2.5% for basic mammary gland parameters and 5–7% for more complex measures. Finally, we provided these adolescents with information about environmental risk factors for breast cancer that they could share with their peers and community and action items to potentially modify their individual risk. We hope that researchers working in this field will engage adolescent researchers in projects to evaluate chemicals that influence breast cancer risk. Summer research programs that inform young adolescents about breast cancer risk factors not only benefit these novice researchers individually but also benefit their communities when they are encouraged to talk about the value of basic science studies, discuss vulnerable periods of mammary gland development, and share what they have learned about cancer and the environment.

A Multi-state Evaluation of Oral Health Students’ Knowledge of Human Papillomavirus-Related Oropharyngeal Cancer and HPV Vaccination

Abstract

Human papillomavirus-related oropharyngeal cancers (HPV-OPCs) are on the rise, yet HPV knowledge among dental professionals remains low. The purpose of this multi-state study was to examine sociodemographic factors associated with final year dental hygiene (DH), third year dental (DS3), and fourth year dental (DS4) students’ knowledge regarding HPV, HPV-OPC, and HPV vaccination. Twenty dental programs in the USA were approached in the implementation phase to complete an online, 153-item, self-administered questionnaire that was developed and tested in a previous study. Descriptive statistics and chi-square analyses were conducted in SAS version 9.4 to examine the relationship between sociodemographic variables with HPV, HPV-OPC, and HPV vaccination knowledge levels. This study included the participation of students from 15 dental programs (n = 380) with an overall response rate of 28%. Although the results cannot be generalized to the entire population of dental students in the USA, most students had inadequate overall HPV knowledge (65%), HPV-OPC knowledge (80%), and HPV vaccination knowledge (55%). While all student groups displayed adequate general HPV knowledge levels (≥ 70% correct responses), gender, racial, religious, age, and regional differences were observed. Future dental professionals need to have adequate levels of HPV knowledge to aid in reducing the HPV-OPC burden. This study identified sociodemographic factors related to lower knowledge of HPV, HPV-OPC, and HPV vaccination, and highlights groups of students with greater needs for HPV education. This study provides a foundation for future research and interventions to be developed. Dental institutions can use findings to strengthen curricula development.

Discussing Sexual Health in the Medical Oncologist’s Practice: Exploring Current Practice and Challenges

Abstract

Sexuality is a significant quality-of-life concern for many cancer patients. Patients may be disadvantaged if they are not informed and not offered sexual health care. We sought to reveal oncologists’ current practice and opinions concerning sexual counselling. The aim of this study was to explore the knowledge, attitude and practice patterns of Dutch medical oncologists regarding treatment-related sexual dysfunction. Questionnaires were sent to 433 members of the Dutch Society of Medical Oncology. The majority (81.5%) of the 120 responding medical oncologists (response rate 30.6%) stated they discussed sexual function with fewer than half of their patients. At the same time, 75.8% of the participating oncologists agreed that addressing sexual function is their responsibility. Sexual function was discussed more often with younger patients and patients with a curative treatment intent. Barriers for avoiding discussing sexual function were lack of time (56.1%), training (49.5%) and advanced age of the patient (50.4%). More than half (64.6%) stated they had little knowledge about the subject and the majority (72.9%) wanted to acquire additional training in sexual function counselling. Medical oncologists accept that sexual function counselling falls within their profession, yet they admit to not counselling patients routinely concerning sexual function. Only in a minority of cases do medical oncologists inform their patients about sexual side effects of treatment. Whether they counsel patients is related to how they view patient’s prognosis, patient’s age, and self-reported knowledge. Findings indicate there is a role for developing education and practical training.

Predictors of Mammography Uptake Among Italian Women Aged 50–69: a Cross-sectional Study

Abstract

Screening coverage is of concern in several countries, including Italy. The aim of the study is to assess predictors of participation in the mammography screening program at the Local Health Unit RMA (Rome, Italy). A telephone-based questionnaire was administered to randomly selected eligible women. The study population was interviewed by the personnel of the health center. Five hundred two women were interviewed, of which 264(52.6%) have attended the breast cancer screening program at least once. The attendees received the invitation letter more often than the non-attendees (88.3% vs. 77.7%; p = 0.002) and were more willing to participate (85.6% vs. 69.3%; p < 0.001). Employees were more among the non-attendees of the screening program (66% vs. 52.3%; p = 0.002). Age over-61 (OR = 2.75; 95%CI 1.84–4.09), receiving the invitation letter (OR = 2.54; 95%CI = 1.52–4.24), and intention to participate (OR = 3.09; 95%CI = 1.94–4.91) were significantly associated with participation in the screening program. Although the invitation rate of the Local Health Unit RMA has improved in recent years, the mammography uptake rate remains very low. The presence of opportunistic screening activities, younger age, and low educational status could explain the low participation rates. Organizational barriers (e.g., screening hours coinciding with work hours, screening facilities located far away) may also limit participation. Major efforts should be made towards the regulation of opportunistic screening activities and reorganization of the screening centers and communication strategies to better comply with the needs of the target population. In this light, the involvement of different healthcare professionals, especially general practitioners, and gynecologists, is crucial.

Involving Patients in the Development and Evaluation of an Educational and Training Experiential Intervention (ETEI) to Improve Muscle Invasive Bladder Cancer Treatment Decision-making and Post-operative Self-care: a Mixed Methods Approach

Abstract

This study aims to describe the acceptability and feasibility of an educational and training experiential intervention (ETEI) we developed to enhance muscle invasive bladder cancer (MIBC) patients with treatment decision-making and post-operative self-care. Twenty-five patients were randomized to a control group (N = 8) or ETEI group (N = 17). ETEI group participated in a nurse-led session on MIBC education. The control group received diet and nutrition education. Study questionnaires were completed at baseline and at 1-month post-intervention. Our results showed acceptable recruitment (58%) and retention rates (68%). The ETEI group reported increased knowledge (82% vs. 50%), improved decisional support (64% vs. 50%), improved communication (73% vs. 50%), and increased confidence in treatment decisions (73% vs. 50%) compared to the control group. Patients in the control group reported improved diet (50% v. 27%) as well as maintaining a healthy lifestyle (67% vs. 45%) compared to the ETEI group. Patients in the ETEI group reported a significant decrease in cancer worries and increases in self-efficacy beliefs over time compared to the control group. The ETEI was feasible, acceptable, and showed a potential for inducing desired changes in cancer worries and efficacy beliefs.

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

Cancer Education