Kidney transplantation: New strategies for longer organ preservation – Science Daily

Kidney transplantation: New strategies for longer organ preservation
Science Daily
These strategies include the most innovative approach to date, which is investigated by Thomas Wekerle (University Department of Surgery): as well as the kidney, bone marrow from the donor is also transplanted into the recipient to get tolerance: this

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Kidney transplantation: New strategies for longer organ preservation – Science Daily

Association of NF-{kappa}B polymorphisms with clinical outcome of non-medullary thyroid carcinoma

The NF-B inflammatory pathway plays a major role in cancer development and clinical progression. Activation of NF-B signaling is promoted by NFKB1 and inhibited by NFKBIA. The present study aimed to determine the relevance of NFKB1 rs4648068 and NFKBIA rs2233406 genetic variants for non-medullary thyroid cancer (NMTC) susceptibility, progression and clinical outcome. This case–control and cohort study consists of a Romanian discovery cohort (157 patients and 258 controls) and a Dutch validation cohort (138 patients and 188 controls). In addition, patient cohorts were analyzed further for the association of genetic variants with clinical parameters. Functional studies were performed on human peripheral blood mononuclear cells. No associations were observed between the studied genetic variants and TC susceptibility. Although no statistically significant associations with clinical parameters were observed for NFKB1 rs4648068, the heterozygous genotype of NFKBIA rs2233406 was correlated with decreased radioactive iodide sensitivity requiring higher cumulative dosages to achieve clinical response. These findings were discovered in the Romanian cohort (P < 0.001) and confirmed in the Dutch cohort (P = 0.01). Functional studies revealed that this NFKBIA rs2233406 genotype was associated with elevated TLR4-mediated IL-1β production. In conclusion, genetic variation in NFKBIA, an inhibitor of NF-B signaling, is associated with clinical response to RAI therapy and with increased production of the pro-inflammatory cytokine IL-1β, providing a potential mechanism for the observed clinical associations. These data suggest that NF-B signaling is involved in NMTC pathogenesis and that the inflammatory tumor microenvironment could contribute to RAI resistance.

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Association of NF-{kappa}B polymorphisms with clinical outcome of non-medullary thyroid carcinoma

Topoisomerase 2{alpha} and thymidylate synthase expression in adrenocortical cancer

Topoisomerase II alpha (TOP2A) and thymidylate synthase (TS) are known prognostic parameters in several tumors and also predictors of efficacy of anthracyclines, topoisomerase inhibitors and fluoropirimidines, respectively. Expression of TOP2A and TS mRNA was assessed in 98 patients with adrenocortical carcinoma (ACC) and protein expression was assessed by immunohistochemistry in a subset of 39 tumors. Ninety-two patients were radically resected for stage II–III disease and 38 of them received adjuvant mitotane. Twenty-six patients with metastatic disease received the EDP-M (etoposide, doxorubicin, Adriamycin, cisplatin plus mitotane). TOP2A and TS expression in ACC tissue was directly correlated with the clinical data. Both markers were not associated with either disease free survival (DFS) or overall survival (OS) in multivariate analyses and failed to be associated to mitotane efficacy. Disease response or stabilization to EDP-M treatment was observed in 12/17 (71%) and 1/9 (11%) patients with high and low TOP2A expressing tumors (P = 0.0039) and 9/13 (69%) and 4/13 (31%) patients with high and low TS expressing ACC, respectively (P = 0.049). High TOP2A expression was significantly associated with longer time to progression (TTP) after EDP-M. TOP2A and TS proteins assessed by immunohistochemistry significantly correlated with mRNA expression. Immunohistochemical TOP2A expression was associated with a non-significant better response and longer TTP after EDP-M. TOP2A and TS were neither prognostic nor predictive of mitotane efficacy in ACC patients. The predictive role of TOP2A expression of EDP-M activity suggests a significant contribution of Adriamycin and etoposide for the efficacy of the EDP scheme.

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Topoisomerase 2{alpha} and thymidylate synthase expression in adrenocortical cancer

Olivia Newton-John’s breast cancer return sparks questions

Recurrence «reinforces that breast cancer is potentially a systemic or whole body disease from the get-go,» UCLA expert says (Source: Health News: CBSNews.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Olivia Newton-John’s breast cancer return sparks questions

Health Care Heroes 2017 Outstanding Medical Researcher — George Peoples

Dr. George Peoples is a world-renowned surgical oncologist whose research in cancer immunotherapy has resulted in five new cancer vaccines directly targeting the recurrence of cancers, all of which have been licensed for commercial development. (Source: bizjournals.com Health Care News Headlines)

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Health Care Heroes 2017 Outstanding Medical Researcher — George Peoples

Odds of late breast cancer increase in isolated areas

The odds of being diagnosed with late-stage breast cancer are higher for women…Read more on AuntMinnie.comRelated Reading: USPSTF: Why do more black women die from breast cancer? CDC: Breast cancer death rate declines, but not equally Breast MR: Is it accessible to women who need it? Younger, poorer women see breast cancer care delays Appalachian women have higher rates of late-stage breast cancer (Source: AuntMinnie.com Headlines)

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via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Odds of late breast cancer increase in isolated areas