Dietary proanthocyanidins prevent ultraviolet radiation-induced non-melanoma skin cancer through enhanced repair of damaged DNA-dependent activation of immune sensitivity

Publication date: Available online 12 April 2017 Source:Seminars in Cancer Biology Author(s): Santosh K. Katiyar, Harish C. Pal, Ram Prasad Numerous plant products have been used to prevent and manage a wide variety of diseases for centuries. These products are now considered as promising options for the development of more effective and less toxic alternatives to the systems of medicine developed primarily in developed countries in the modern era. Grape seed proanthocyanidins (GSPs) are of great interest due to their anti-carcinogenic effects that have been demonstrated using various tumor models including ultraviolet (UV) radiation-induced non-melanoma skin cancer. In a pre-clinical mouse model supplementation of a control diet (AIN76A) with GSPs at concentrations of 0.2% and 0.5% (w/w)…

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Dietary proanthocyanidins prevent ultraviolet radiation-induced non-melanoma skin cancer through enhanced repair of damaged DNA-dependent activation of immune sensitivity

How to study and overcome tumor heterogeneity with circulating biomarkers: The breast cancer case

Publication date: Available online 22 April 2017 Source:Seminars in Cancer Biology Author(s): Valentina Appierto, Serena Di Cosimo, Carolina Reduzzi, Valentina Pala, Vera Cappelletti, Maria Grazia Daidone Breast cancer ranks first among female cancer-related deaths in Western countries. As the primary tumor can often be controlled by surgical resection, the survival of women with breast cancer is closely linked to the incidence of distant metastases. Molecular screening by next generation sequencing highlighted the spatial and temporal heterogeneity of solid tumors as well as the clonal evolution of cancer cells during progression and under treatment pressure. Such findings question whether an optimal assessment of disease progression and a screening for druggable mutations should be base…

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How to study and overcome tumor heterogeneity with circulating biomarkers: The breast cancer case

Non-overlapping Promoter and Super-enhancer Driven Processes Support Myeloma Cell Growth and Survival via Distinct Regulatory Axes

Publication date: February 2017 Source:Clinical Lymphoma Myeloma and Leukemia, Volume 17, Issue 1, Supplement Author(s): Mariateresa Fulciniti, Charles Lin, Mehmet Samur, Rick Young, Kenneth C. Anderson, Herve Avet-Loiseau, James Bradner, Nikhil Munshi (Source: Clinical Lymphoma Myeloma and Leukemia)

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Non-overlapping Promoter and Super-enhancer Driven Processes Support Myeloma Cell Growth and Survival via Distinct Regulatory Axes

Mitochondrial Ribosomes in Cancer

Publication date: Available online 23 April 2017 Source:Seminars in Cancer Biology Author(s): Hyun-Jung Kim, Priyanka Maiti, Antoni Barrientos Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells. They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) system, and harbor and control the intrinsic pathway of apoptosis. As a descendant of a bacterial endosymbiont, mitochondria retain a vestige of their original genome (mtDNA), and its corresponding full gene expression machinery. Proteins encoded in the mtDNA, all components of the multimeric OXPHOS enzymes, are synthesized in specialized mitochondrial ribosomes (mitoribosomes). Mitoribosomes are therefore essential in the regulation of cellular respiration. Additionally, …

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Mitochondrial Ribosomes in Cancer

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Publication date: February 2017 Source:Clinical Lymphoma Myeloma and Leukemia, Volume 17, Issue 1, Supplement (Source: Clinical Lymphoma Myeloma and Leukemia)

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Prostate brachytherapy, either alone or in combination with external beam radiation, is associated with longer overall survival in men with favorable pathologic Group 4 (Gleason score 8) prostate cancer

Conventional prostate cancer risk stratification results in considerable heterogeneity within each prognostic group. Men with pathologic grade Group 4 (Gleason score 8) but otherwise low-risk features have been identified as a favorable subset of high-risk prostate cancer. Given recent randomized data supporting improved cancer outcome with brachytherapy in intermediate- and high-risk prostate cancer, we sought to evaluate brachytherapy utilization and overall survival (OS) for these patients. (Source: Brachytherapy)

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Prostate brachytherapy, either alone or in combination with external beam radiation, is associated with longer overall survival in men with favorable pathologic Group 4 (Gleason score 8) prostate cancer

Tea phytochemicals for breast cancer prevention and intervention: From bench to bedside and beyond

Publication date: Available online 7 April 2017 Source:Seminars in Cancer Biology Author(s): Dona Sinha, Jaydip Biswas, Seyed Mohammad Nabavi, Anupam Bishayee The National Cancer Institute of the United States had projected breast cancer as one of the topmost prevalent malignancies of 2016. It was estimated that in 2016, 246,660 new cases of invasive breast cancer were expected to be diagnosed in women in the US, along with 61,000 new cases of non-invasive (in situ) breast cancer. The heterogeneity of breast cancer accounts for its differential molecular subtyping. Recent incorporation of high throughput approaches helps early prognosis of breast cancer, but recurrence of the disease stands to be one of the most daunting fact behind non-availability of third line treatment. At this point …

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Tea phytochemicals for breast cancer prevention and intervention: From bench to bedside and beyond