Molecular–genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss: gain of chromosome 19p and histological grade III negatively correlate with patient’s prognosis

Abstract

Although 1p19q codeleted gliomas are the most favorable molecular subgroup of lower-grade gliomas, there are cases with early recurrence or short survival. The objective of this study was to elucidate molecular–genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss. The study included 57 consecutive patients with codeleted gliomas who were operated at Keio University Hospital between 1990 and 2010. These patients were assessed for chromosomal copy number aberrations, promoter methylation status of the O6-methylguanine-DNA methyltransferase gene (MGMT), and demographic and clinicopathological prognostic factors in diffuse gliomas. No significant difference was observed in the overall survival (OS) of the patients with respect to age (≥40 years vs. <40 years), degree of resection, maximum tumor diameter (≥5 cm vs. <5 cm), histological subtype, and MGMT promoter methylation status. Gain of chromosome 19p and grade III histology were associated with shorter OS (P = 0.019, 0.061, respectively). Gain of 19p and histological grade III might be negative prognostic factors for the patients with gliomas showing total 1p19q loss. Further investigation is warranted to confirm these notions.

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Molecular–genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss: gain of chromosome 19p and histological grade III negatively correlate with patient’s prognosis

Health behavioral theories used to explain dietary behaviors in adolescents: a systematic review

Background: Health behavior theories are useful to interpret adolescents’ dietary behaviors. Evidences show that theories are influenced by social and psychological determinants. So, the purpose of this study is to systematically review studies that tested social cognitive theories (non-integrated) that predict adolescents’ dietary behaviors. Methods: A structured electronic search of all publication years (through April 2016) was conducted to identify studies in MEDLINE, SciELO, PsycINFO, Scopus, and LILACS with full text. Included publications were cross-sectional and longitudinal (non-intervention) studies involving adolescents (10 to 18 years) that examined the associations between constructs of social-cognitive theories and dietary behaviors. Related strings in titles, abstracts, and indexing fields were searched. Results: Theories used to explain dietary intake were the planned behavior and the social cognitive. It was observed evidences of positive associations between the social cognitive constructs and the fruits, the vegetables, the milk groups, and the whole-wheat foods (e.g., bread rich in fiber) and negative associations with sugar-sweetened beverages, soft drinks, snacks high in fat, sugar, and/or sodium, and sweet treats. Theories explained greater proportion of variance for intention to dietary intake. The variance for intention ranged from 3% for pizzas, candy bars, candies, and sugar-sweetened beverages to 68% for whole-wheat food (i.e., bread rich in fiber). Conclusion: Longitudinal designs are necessary to comprehend the theories and evaluate the behavioral changes. Finally, the use of food groups should be employed in the studies to help the comparisons and present higher reproducibility. Studies always based on objective, systematic, and rigorous evidences.

from #Cancer-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2ilKRHV
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Health behavioral theories used to explain dietary behaviors in adolescents: a systematic review

Risks of second malignancies after breast cancer treatment: Long-term results

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Publication date: Available online 26 December 2016
Source:Cancer/Radiothérapie
Author(s): L. Bazire, Y. De Rycke, B. Asselain, A. Fourquet, Y.M. Kirova
PurposeTo estimate the long-term risk of second malignancies after breast cancer treatment in a large homogeneous cohort from a single institution.Patients and methodsAll patients in this study were treated for non-metastatic breast cancer at the Curie institute, Paris, between 1981 and 2000. We calculated the cumulative incidence of second malignancies and the risk of developing each type of second malignancies over a period of 10 to 15 years. The observed crude incidence rates in the entire patient population were then compared to the expected incidence in the general population of French women, as provided by age-standardized data. A standardized incidence ratio (SIR) was calculated for all second malignancies. We also calculated second malignancies standardized incidence ratios for patients who underwent adjuvant therapy for breast cancer.ResultsThe study cohort included a total of 17,745 women. The median follow-up since diagnosis was 13.4 years (range: 2–29 years). The 15-year cumulative incidence of second malignancies was 1.807 per 100,000 (CI 1.729–1.884). A total of 2370 second malignancies were observed during follow-up, 2010 in the radiotherapy arm and 360 in the no radiotherapy arm (relative risk [RR] 1.15 [1.03–1.28], P=0.0134). Crude incidence rates were significantly higher in our cohort than in the general population for contralateral breast cancer (SIR 2.96 [confidence interval (CI) 2.82–3.12], P<0.0001), sarcomas (SIR 8.48 [CI 6.41–11.22], P<0.0001), leukaemia (SIR 2.37 [CI 1.85–3.04], P<0.0001), lung cancer (SIR 1.39 [CI 1.13–1.72], P<0.0022) and gynaecological cancer (SIR 1.31 [CI 1.15–1.50], P=0.0001). Among patients treated for breast cancer, those who received radiotherapy was associated with an excess risk of sarcoma as compared to those have not had (RR 5.59 [CI 1.35–23.17], P<0.001).ConclusionsWomen treated for breast cancer had a significantly increased risk of several kinds of second malignancies compared to the general population.

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Risks of second malignancies after breast cancer treatment: Long-term results

Implementation of intensity-modulated radiotherapy for head and neck cancers in routine practice

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Publication date: Available online 27 December 2016
Source:Cancer/Radiothérapie
Author(s): C. Bednarek, T.V.F. Nguyen, M. Puyraveau, É. Bonnet, N. Lescut, C. Azélie, J. Miny, O. Mauvais, T. Maurina, F. Tochet, J.-F. Bosset, J. Thariat, X.S. Sun
PurposeTo report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre.Patients and methodsBetween 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1.5%) at the university hospital of Besançon. There were stage I and II 9%, III 24.5%, IV 66.5%. One hundred and thirty-eight underwent exclusive intensity-modulated radiotherapy, 50 underwent postoperative intensity-modulated radiotherapy, 174 had concurrent chemotherapy, 57 had induction chemotherapy. Dynamic intensity-modulated radiotherapy with static fields was performed for all patients using sequential irradiation in 174 patients and simultaneous integrated boost irradiation in 14 patients.ResultsWith a median follow-up was 27.5 months, there was 79% of locoregional failures occurred in the 95% isodose. Two-year overall survival, disease-free, local failure-free and locoregional failure-free survival rates were73%, 60%, 79% and 72%, respectively. Prognostic factors for disease-free survival were stage (IV vs. I–III) with a relative risk of 1.7 [1.1–2.8] (P=0.02) and T stage with 1.6 [1.04–2.5] (P=0.03).ConclusionThe current series showed similar patterns of failure as in other tertiary care centres. We did not identify intensity-modulated radiotherapy specific relapse risks.

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Implementation of intensity-modulated radiotherapy for head and neck cancers in routine practice

Mammography rates after the 2009 revision to the United States Preventive Services Task Force breast cancer screening recommendation

Abstract

Background

In 2009, the United States Preventive Services Task Force (USPSTF) recommended against routine mammography screening for women aged 40–49 years. This revised recommendation was widely criticized and has sparked off intense debate. The objectives of this study are to examine the impact of the revised recommendation on the proportion of women receiving mammograms and how the effect varied by age.

Methods

We identified women who had continuous health insurance coverage and who did not have breast cancer between 2008 and 2011 in the Truven Health MarketScan Commercial Claims Databases using mammogram procedure codes. Using women aged 50–59 years as a control group, we used a differences-in-differences approach to estimate the impact of the revised recommendation on the proportion of women ages 40–49 years who received at least one mammogram. We also compared the age-specific changes in the proportion of women ages 35–59 years who were screened before and after the release of the revised recommendation.

Results

The proportion of women screened among the 40–49 and 50–59 age groups were 58.5 and 62.5%, respectively, between 2008 and 2009, and 56.9 and 62.0%, respectively, between 2010 and 2011. After 2009, the proportion of women screened declined by 1.2 percentage point among women aged 40–49 years (P < 0.01). The proportion of women screened decreased for all ages, and decreases were larger among women closer to the 40-year threshold.

Conclusions

The 2009 USPSTF breast cancer recommendation was followed by a small reduction in the proportion of insured women aged 40–49 years who were screened. Reductions were larger among women at the younger end of the age range, who presumably had less prior experience with mammography than women nearing 50.

from #Cancer-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2ivkpyT
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Mammography rates after the 2009 revision to the United States Preventive Services Task Force breast cancer screening recommendation

What do we know of Roman wall painting technique? Potential confounding factors in ancient paint media analysis

The theory of fresco as the standard painting technique in Roman wall paintings, formulated in the mid-1960s by Paolo Mora and Laura Mora and Paul Philippot, has enjoyed general acceptance among specialists to the present day. However, the fresco theory is based on a series of postulates—such as the feasibility of fresco on pontate, the presence of giornate, or the use of alkali-sensitive pigments—which appear to be unsupported by physical or experimental evidence and which would require further assessment in order to validate the theory. Additionally, chemical analyses of Roman murals have identified the presence of various types of organic binders. A comparative study of these analyses reveals a remarkable difference between results obtained by the different researchers. The clustering of results by research group appears highly unlikely, suggesting the possible presence of confounding factors which could lead to distorted results. These factors might be related both to the difficulty in extracting ancient paint media and the influence of biological contamination. If the extraction method used is not adequate for an ancient binding medium, then part of the binder may not be extracted, producing an incomplete characterization of its composition. The lack of data on both the efficiency of the methods used and the possible influence of microbial contamination in the organic material may cause uncertainty in the degree of reliability of the different results obtained, fomenting uncertainty around the techniques used in ancient paintings as well as the treatments suitable for their conservation. Therefore, in the analysis of ancient paint media, the implementation of a protocol of assessment of both the efficiency of the extraction methods and the influence of biological contamination seems advisable.Graphical abstract.

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via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

What do we know of Roman wall painting technique? Potential confounding factors in ancient paint media analysis

Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer

Abstract

Purpose

Breast cancer is a significant global public health issue. It is the leading cause of death among women around the world, with an incidence increasing annually. In recent years, there has been more and more information in the literature regarding a protective role of vitamin D in cancer. Increasingly preclinical and clinical studies suggest that vitamin D optimal levels can reduce the risk of breast cancer development and regulate cancer-related pathways.

Method

In this review, we focus on the importance of vitamin D in breast cancers, discussing especially the influence of vitamin D signaling on estrogen receptor and human epidermal growth factor receptor 2 (HER2), two major biomarkers of breast cancer today.

Conclusion

We discuss the possibility of actual and future targeted therapeutic approaches for vitamin D signaling in breast cancer.

from #Cancer-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2iydS1Z
via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Influence of vitamin D signaling on hormone receptor status and HER2 expression in breast cancer