Cancer poses an enormous burden on society, both in well- and less economically developed countries. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths from cancer occurred in 2012 worldwide.  Colorectal cancer (CRC) is one of the most prevalent types of cancer in the world, particularly in developed countries. According to GLOBOCAN, it is the third most common malignancy in men and second in women, estimated to cause 694,000 deaths in 2012 globally.  CRC incidence and mortality in the Western world has decreased over the past decade, probably as a consequence of wider use of screening, earlier detection of symptomatic disease and more effective therapy.
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