The price of target dose uniformity

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Publication date: Available online 30 July 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): David Craft, Fazal Khan, Michael Young, Thomas Bortfeld

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The price of target dose uniformity

Upregulation of long noncoding RNA SNHG18 promotes radioresistance of glioma by repressing Sema5A

Publication date: Available online 30 July 2016
Source:International Journal of Radiation Oncology*Biology*Physics
Author(s): R. Zheng, Q.W. Yao, C. Ren, Y. Liu, H.L. Yang, G.Z. Xie, S.S. Du, K.J. Yang, Y.W. Yuan
Although there is increasing evidence that long noncoding RNAs (lncRNAs) play an important regulatory role in carcinogenesis and tumor progression, little is known about the role of small nucleolar RNA host gene 18 (SNHG18) in cancer. This study investigated the clinical associations of SNHG18 and its role in glioma. Our results showed that the expression level of SNHG18 was remarkably up-regulated in clinical glioma tissues compared with normal brain tissues.SNHG18 expression was associated with the clinical tumor grade and was negatively correlated with IDH1 mutation. In addition, knockdown of SNHG18 with short hairpin RNA suppressed the radioresistance of glioma cells, whereas transgenic expression of SNHG18 had the opposite effect. Furthermore, xenograft tumors grown from cells with SNHG18 deletion were more radiosensitive than tumors grown from control cells. Further studies revealed that SNHG18 promotes radioresistance by inhibiting Sema5A, and that inhibition of Sema5A expression abrogated the radiosensitizing effect caused by SNHG18 deletion. Our findings provide new insights into the role of SNHG18 in glioma, and suggest its potential as a target for glioma therapy.

Teaser

SNHG18 is significantly up-regulated in clinical glioma tissues and is negatively associated with Sema5A expression. Inhibition of SNHG18 is able to suppress glioma cell radioresistance. The promotion effect of SNHG18 deletion in radiosensitivity was rescued by suppression of Sema5A.

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Upregulation of long noncoding RNA SNHG18 promotes radioresistance of glioma by repressing Sema5A

Armour: NFL can’t afford to miss on chief medical officer hire – USA TODAY

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USA TODAY
Armour: NFL can’t afford to miss on chief medical officer hire
USA TODAY
The head of the league’s research subcommittee, Russell Lonser, cites the treatment of “brain, temporal bone and spinal cord tumors,” as his areas of clinical and surgical interest on the Society of Neurological Surgeons website. And Betsy Nabel, the
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Armour: NFL can’t afford to miss on chief medical officer hire – USA TODAY

If the West Coast were more involved, there wouldn’t be as many major delays – The Spokesman Review (registration) (blog)

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The Spokesman Review (registration) (blog)
If the West Coast were more involved, there wouldn’t be as many major delays
The Spokesman Review (registration) (blog)
The Hawks opened training camp yesterday. Michael Bennett, he of the contract he feels is not good enough, did not hold out. He just doesn’t do that sort of thing. He also didn’t hold his tongue. He doesn’t do that sort of thing either. Of that we

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If the West Coast were more involved, there wouldn’t be as many major delays – The Spokesman Review (registration) (blog)

Ensure oral health before chemo – The Asian Age

Ensure oral health before chemo
The Asian Age
Cancer patients are found to face oral health problems like dryness of mouth, change in sense of taste, mouth sores, difficulty in swallowing, breaking of teeth and pain in gums, especially as they undergo chemotherapy, radiation and surgery. These are

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Ensure oral health before chemo – The Asian Age

Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells

Accumulating evidences have demonstrated that mesenchymal stem cells (MSC) could be recruited to the tumor microenvironment. Umbilical cord mesenchymal stem cells (UCMSC) were attractive vehicles for deliverin…

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Mesenchymal stem cells enhance the metastasis of 3D-cultured hepatocellular carcinoma cells

Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer

Collapsin response mediator proteins (CRMPs) were originally identified in the nervous system and are involved in neuronal development. Similar to CRMP1, CRMP4 has a shorter transcript encoding a short isoform…

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Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer