Manitoba lady who needed inquiry into asbestos-tainted insulation dies – The Times (subscription)

Manitoba lady who needed inquiry into asbestos-tainted insulation dies
The Times (subscription)
The World Health Organization maintains all types of asbestos can cause lung cancer, mesothelioma, cancer of the larynx and ovary, and asbestosis. ThunderSky was also active in campaigning for a national inquiry into missing and murdered indigenous …

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Manitoba lady who needed inquiry into asbestos-tainted insulation dies – The Times (subscription)

Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response

Abstract

Background

Preclinical results showing therapeutic effect and low toxicity of metronomic chemotherapy with cyclophosphamide (Cy) + celecoxib (Cel) for mammary tumors encouraged its translation to the clinic for treating advanced breast cancer patients (ABCP).

Patients and methods

A single-arm, mono-institutional, non-randomized, phase II, two-step clinical trial (approved by Bioethics Committee and Argentine Regulatory Authority) was designed. Patients received Cy (50 mg po.d) + Cel (200 mg p.o.bid). Patient eligibility criteria included: ABCP who progressed to anthracyclines, taxanes and capecitabine, ≤4 chemotherapy schemes, with good performance status. Several pro- and anti-angiogenic molecules and cells were determined as biomarkers. Informed consent was signed by all patients. Primary endpoint was clinical benefit (CB).

Results

Twenty patients were enrolled. Main clinical outcomes were prolonged disease stabilization and partial remission in 10/20 and 1/20 patients, respectively. CB was 55 %, and time to progression (TTP) was 21.1 weeks. Median TTP in patients who achieved CB was 35.6 weeks, and mean overall survival was 44.20 weeks. There were no grade 3/4 toxicities associated with treatment. Circulating endothelial cells (CECs) increased at the time of progression in patients who showed CB (P = 0.014). Baseline CECs and circulating endothelial progenitor cells showed marginal associations with TTP. Serum VEGF decreased (P = 0.050), sVEGFR-2 increased (P = 0.005) and VEGF/sVEGFR-2 ratio decreased during treatment (P = 0.041); baseline VEGF and VEGF/sVEGFR-2 were associated with TTP (P = 0.035 and P = 0.030, respectively), while sVEGFR-2 did not.

Conclusions

Treatment was effective, showing low toxicity profile and excellent tolerability. The combination had anti-angiogenic effect. Increased levels of CEC could be useful for detecting progression. Baseline VEGF and VEGF/sVEGFR-2 values could be useful as early predictors of response.

Trial registration

ANMAT#4596/09.

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Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response

Danielle Allen: We already know how to win the war on drugs – Kansas City Star (blog)

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Kansas City Star (blog)
Danielle Allen: We already know how to win the war on drugs
Kansas City Star (blog)
In January 1964, the Beatles first broke onto the Billboard chart with “I Want to Hold Your Hand”; by June, Ringo Starr had collapsed from tonsillitis and pharyngitis. That January, the surgeon general announced that scientists had found conclusive
Gov. Ige signs bill raising legal smoking age in Hawaii to 21Hawaii News Now
DON to Comply with New Hawaii Tobacco Law – U.S. NavyU.S. Navy
SB 1030 – Hawaii State LegislatureHawaii State Legislature

all 341 news articles »

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Danielle Allen: We already know how to win the war on drugs – Kansas City Star (blog)

“May the Odds Be Ever in Your Favor” – The Ten Best Prescription Drug/Medical … – JD Supra (press release)

“May the Odds Be Ever in Your Favor” – The Ten Best Prescription Drug/Medical …
JD Supra (press release)
The medical treatments were different, and so were the doctors, hospitals, and the informational and temporal context in which each individual case arose. The non-California claims could be brought in those plaintiffs’ home states, … Bone Screw cases

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“May the Odds Be Ever in Your Favor” – The Ten Best Prescription Drug/Medical … – JD Supra (press release)

20 easy food swaps to help you eat healthier – CNN

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CNN
20 easy food swaps to help you eat healthier
CNN
Top it with wasabi, which is anti-inflammatory and certainly clears the sinuses. … Baking instead of frying slashes calories and prevents the formation of certain cancer-causing compounds which may develop when cooking with oil at high temperatures.

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20 easy food swaps to help you eat healthier – CNN

Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response

Abstract

Background

Preclinical results showing therapeutic effect and low toxicity of metronomic chemotherapy with cyclophosphamide (Cy) + celecoxib (Cel) for mammary tumors encouraged its translation to the clinic for treating advanced breast cancer patients (ABCP).

Patients and methods

A single-arm, mono-institutional, non-randomized, phase II, two-step clinical trial (approved by Bioethics Committee and Argentine Regulatory Authority) was designed. Patients received Cy (50 mg po.d) + Cel (200 mg p.o.bid). Patient eligibility criteria included: ABCP who progressed to anthracyclines, taxanes and capecitabine, ≤4 chemotherapy schemes, with good performance status. Several pro- and anti-angiogenic molecules and cells were determined as biomarkers. Informed consent was signed by all patients. Primary endpoint was clinical benefit (CB).

Results

Twenty patients were enrolled. Main clinical outcomes were prolonged disease stabilization and partial remission in 10/20 and 1/20 patients, respectively. CB was 55 %, and time to progression (TTP) was 21.1 weeks. Median TTP in patients who achieved CB was 35.6 weeks, and mean overall survival was 44.20 weeks. There were no grade 3/4 toxicities associated with treatment. Circulating endothelial cells (CECs) increased at the time of progression in patients who showed CB (P = 0.014). Baseline CECs and circulating endothelial progenitor cells showed marginal associations with TTP. Serum VEGF decreased (P = 0.050), sVEGFR-2 increased (P = 0.005) and VEGF/sVEGFR-2 ratio decreased during treatment (P = 0.041); baseline VEGF and VEGF/sVEGFR-2 were associated with TTP (P = 0.035 and P = 0.030, respectively), while sVEGFR-2 did not.

Conclusions

Treatment was effective, showing low toxicity profile and excellent tolerability. The combination had anti-angiogenic effect. Increased levels of CEC could be useful for detecting progression. Baseline VEGF and VEGF/sVEGFR-2 values could be useful as early predictors of response.

Trial registration

ANMAT#4596/09.

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Metastatic breast cancer patients treated with low-dose metronomic chemotherapy with cyclophosphamide and celecoxib: clinical outcomes and biomarkers of response

Eugenie ‘Ersy’ Schwartz, New Orleans surrealist sculptor, has died – NOLA.com

1R0UGJ6
NOLA.com
Eugenie ‘Ersy’ Schwartz, New Orleans surrealist sculptor, has died
NOLA.com
She posed one bronze rodent in a tiny bathtub as a tongue-in-cheek tribute to Jacques-Louis David’s patriotic 18th-century masterpiece «The Death of Marat.» Sumrall said … She also revealed that Ms. Schwartz had been treated for lung cancer. Two

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Eugenie ‘Ersy’ Schwartz, New Orleans surrealist sculptor, has died – NOLA.com