Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan

Abstract

Background

The epidemiology of secondary cancers in childhood cancer survivors has been unknown in Asian countries. Our aim is to assess the incidence and risk factors for secondary cancers through a nationwide survey in Japan.

Methods

A retrospective cohort study comprising 10,069 children who were diagnosed with cancer between 1980 and 2009 was conducted in 15 Japanese hospitals. The cumulative incidence rate was calculated using death as the competing risk and compared by the Gray method. The standardized incidence ratio (SIR) was defined as the ratio of the number of observed cancers divided by the number of expected cancers. The risk factors were analyzed using Cox regression analysis.

Results

One hundred and twenty-eight patients (1.3 %) developed secondary cancers within a median follow-up of 8.4 years. The cumulative incidence rate was 1.1 % (95 % confidence interval [CI] 0.9–1.4) at 10 years and 2.6 % (95 % CI 2.1–3.3) at 20 years after primary cancer diagnosis. Sensitivity analysis, limited to 5-year survivors (n = 5,387), confirmed these low incidence rates. The SIR of secondary cancers was 12.1 (95 % CI 10.1–14.4). In the Cox analysis, the hazard ratios for secondary cancers were 3.81 (95 % CI 1.53–9.47) for retinoblastoma, 2.78 (95 % CI 1.44–5.38) for bone/soft tissue sarcomas, and 1.81 (95 % CI 1.16–2.83) for allogeneic stem cell transplantation.

Conclusions

The cumulative incidence of secondary cancers in children in Japan was not high; however, the SIR was relatively high. Retinoblastoma or sarcoma in addition to allogeneic stem cell transplantation were significant risk factors for secondary cancers.

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Secondary cancers after a childhood cancer diagnosis: a nationwide hospital-based retrospective cohort study in Japan

Why Do Some People Find Deepak Chopra Quotes Deep And Not Dung? – Forbes

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Forbes
Why Do Some People Find Deepak Chopra Quotes Deep And Not Dung?
Forbes
But what emerges from this seemingly tongue-in-cheek research—the first author is pretty pleased at having used the word “bullshit” ~200 times in the paper—is something more, um, profound than might be expected. … But more profoundly (sorry), this

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Why Do Some People Find Deepak Chopra Quotes Deep And Not Dung? – Forbes

Study offers insights to how ovarian cancer grows, and potential to stop it

Can any cancer cell form another tumour, or is it only select cancer stem cells that give rise to new cancer cells? The answer, a new study finds, is both. Researchers at the University of Michigan Comprehensive Cancer Center looked at human ovarian…

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Study offers insights to how ovarian cancer grows, and potential to stop it

Some Splendours, Some Miseries – Morung Express

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Morung Express
Some Splendours, Some Miseries
Morung Express
‘The School Boy’ by William Blake came a familiar welcoming tone through the larynx of his literature teacher. The boy remained hypnotized on his teacher’s wise phizog. His teacher with his gesture and deep-insights would often bring in the whole

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Some Splendours, Some Miseries – Morung Express

Oncogenic PTEN functions and models in T-cell malignancies – Nature.com

Oncogenic PTEN functions and models in T-cell malignancies
Nature.com
As truncated PTEN proteins undergo rapid degradation, exon 7 mutations are associated with lost or reduced PTEN expression. This clustered spectrum of mutations on exon 7 is an intriguing finding, as it is very specific to T-ALL. In other forms of

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Oncogenic PTEN functions and models in T-cell malignancies – Nature.com

Characterization of miR-146a and miR-155 in blood, tissue and cell lines of head and neck squamous cell carcinoma patients and their impact on cell proliferation and migration

Conclusions Characterizing the expression of miR-146a and miR-155 and their functional role in tumor biology underlined significantly their proliferation and migration potential suggesting relevance as potential prognostic markers in HNSCC. (Source: Journal of Cancer Research and Clinical Oncology)

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Characterization of miR-146a and miR-155 in blood, tissue and cell lines of head and neck squamous cell carcinoma patients and their impact on cell proliferation and migration

Radiolabeled liposome imaging determines an indication for liposomal anticancer agent in ovarian cancer mouse xenograft models

Liposomal anticancer agents can effectively deliver drugs to tumor lesions, but their therapeutic effects are enhanced in only limited number of patients. Appropriate biomarkers to identify responder patients to these liposomal agents will improve their treatment efficacies. We carried out pharmacological and histopathological analyses of mouse xenograft models bearing human ovarian cancers (Caov‐3, SK‐OV‐3, KURAMOCHI, and TOV‐112D) to correlate the therapeutic effects of doxorubicin‐encapsulated liposome (Doxil®) and histological characteristics linked to the enhanced permeability and retention effect. We next generated 111In‐encapsulated liposomes to examine their capacities to determine indications for Doxil® treatment by single‐photon emission computed tomography (SPECT…

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Radiolabeled liposome imaging determines an indication for liposomal anticancer agent in ovarian cancer mouse xenograft models